Results 81 to 90 of about 1,632 (144)

Aconitate Decarboxylase 1 Deficiency Exacerbates Mouse Colitis Induced by Dextran Sodium Sulfate

, 2022
Ulcerative colitis is a complex inflammatory bowel disorder disease that can induce rectal and colonic dysfunction. Although the prevalence of IBD in Western countries is almost 0.5% of the general population, genetic causes are still not fully ...
Ho Won Kim, A-Reum Yu, Ji Won Lee, Byung Soo Lee, Jake Whang, Hwan-Woo Park, Young Ik Lee, Sung Ki Lee, Hoe Sun Yoon, Jong-Seok Kim   +9 more
core   +1 more source

Convergent mitochondrial toxicity of fluorinated agents in oncological anaesthesia: sevoflurane, 5-fluorouracil, and the ACOD1/itaconate immune axis

Frontiers in Anesthesiology
Aconitate decarboxylase 1 (ACOD1, formerly IRG1) and its product itaconate have emerged as central regulators of tumour immune surveillance: ACOD1-derived itaconate in tumour-associated macrophages (TAMs) suppresses inflammatory gene expression and ...
Ivan N. Dushin
doaj   +1 more source

Ferroptosis in breast cancer: From adipocyte–immune–iron regulation to therapeutic application

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Ferroptosis in breast cancer is regulated by an integrated adipocyte–immune–iron network rather than by tumour‐intrinsic pathways alone. Adipocyte‐derived lipid substrates and redox metabolites, immune‐cell‐mediated cytokine signalling and iron‐dependent oxidative stress collectively shape a dynamic ferroptosis ecosystem that can shift tumours towards ...
Juan Sun, Yang Qu, Ru Yao, Yidong Zhou
wiley   +1 more source

Radiation-induced upregulation of itaconate in macrophages promotes the radioresistance of non-small cell lung cancer by stabilizing NRF2 protein and suppressing immune response

Redox Biology
Radioresistance is one of the important reasons for local recurrence and distant metastasis in non-small cell lung cancer (NSCLC). Itaconate primarily functions as an anti-inflammatory metabolite in macrophages, however, its role in radiotherapy remains ...
Mengjie Che, Wenwen Wei, Xiao Yang, Jinzi Liang, Yan Li, Ying Ye, Yajie Sun, Yan Hu, Zhanjie Zhang, You Qin, Jing Huang, Bian Wu, Haibo Zhang, Kunyu Yang, Chao Wan, Lu Wen   +15 more
doaj   +1 more source

Enhanced susceptibility of B. abortus infected Acod1^-/- mice is not associated to different cell recruitment in the lungs.

, 2021
Wild-type and Acod1-/- C57BL/6 mice were intranasally infected with 107 CFU of wild-type mCherry expressing B. abortus 2308. At 9 days post-infection, mice were sacrificed and lungs were harvested.
Mégane Van Gysel (11436992), Véronique Flamand (488613), Stanislas Goriely (365243), Johan Wouters (49810), Abdulkader Azouz (8267025), Xavier De Bolle (6943391), Jan Abendroth (278420), Audrey Comein (11436986), Elodie Carlier (6535262), Justine Smout (11436989), Arnaud Machelart (176325), Thomas E. Edwards (9682), Aurore Demars (5618984), Armelle Vitali (11436983), Eik Hoffmann (80515), Priscille Brodin (57030), Eric Muraille (176330)   +16 more
core   +1 more source

Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation

iScience
Summary: Peroxiredoxin 1 (PRDX1), an intracellular antioxidant enzyme, has emerged as a regulator of inflammatory responses via Toll-like receptor 4 (TLR4) signaling.
Jisu Park, Sanggil Kim, Hye-Yeon Jung, Eun Hwan Bae, Minhye Shin, Jae-Il Park, So-Young Choi, Sun-Ju Yi, Kyunghwan Kim   +8 more
doaj   +1 more source

Control of immune cell signaling by the immuno-metabolite itaconate

Frontiers in Immunology
Immune cell activation triggers signaling cascades leading to transcriptional reprogramming, but also strongly impacts on the cell’s metabolic activity to provide energy and biomolecules for inflammatory and proliferative responses. Macrophages activated
Roland Lang, Roland Lang, Md Nur A Alam Siddique   +2 more
doaj   +1 more source

Protocol to study the role of endogenously produced itaconate using CRISPR-Cas9 technology in THP-1 cells

STAR Protocols
Summary: Itaconate mimetics inadequately represent endogenous itaconate, a negative regulator of innate immune-driven pro-inflammatory cytokines. We present a CRISPR-Cas9 protocol to delete a 4-nucleotide region in the immunoresponsive gene 1 (IRG1 ...
Luke A. Bourner, Katie A. Acken, Haiyan Long, Linda A. Chung, Kenneth D. Roth, Frank C. Dorsey   +5 more
doaj   +1 more source

IL-10/ACOD1 axis regulates catabolism of phagocytosed lipids in trained macrophages

Macrophages clear excess host and microbial debris to restore homeostasis in inflamed tissues, yet the regulation and molecular fate of phagocytosed lipids during innate immune training remains largely unexplored. Leveraging stable isotope tracing of
Annalise Bond, Matthew P. Donnelly, Emeline Joulia, Melissa A. Johnson, Janelle S. Ayres, Matthew J. Kolar, Mack B. Reynolds, Christian M. Metallo, Gladys R. Rojas, Gerald S. Shadel, Aurélie Laguerre, Kym J. Grae, Emily M.J. Fennell   +12 more
core   +1 more source

Toxoplasma gondii and Neospora caninum Infection is Compromised by the Action of Cis-Aconitate Decarboxylase (acod1)

Toxoplasma gondii and Neospora caninum are parasites of the Apicomplexa phylum responsible for causing diseases and economic losses worldwide. T. gondii poses a risk to human health and can cause toxoplasmosis, which is known to cause abortions in cases ...
Silva, João Vitor Eleuterio da
core   +1 more source