Results 91 to 100 of about 1,632 (144)

Effect of pH and buffer on substrate binding and catalysis by cis-aconitate decarboxylase

Scientific Reports
cis-Aconitate decarboxylase (ACOD1, CAD, IRG1) catalyses the synthesis of itaconic acid in activated myeloid cells such as macrophages. Several histidine residues in the active site bind the substrate and enable the decarboxylation reaction. The in vitro
Mingming Zhao, Chutao Chen, Wulf Blankenfeldt, Frank Pessler, Konrad Büssow   +4 more
doaj   +1 more source

Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

eLife
One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate.
Rabina Mainali, Nancy Buechler, Cristian Otero, Laken Edwards, Chia-Chi Key, Cristina Furdui, Matthew A Quinn   +6 more
doaj   +1 more source

Itaconate and obesity-related hormones promote tumor progression – new insights on metabolic dysfunction in early-onset colon cancer

Frontiers in Immunology
IntroductionObesity is a strong risk factor for early-onset colon cancer (EOCC) and is associated with chronic inflammation largely mediated by macrophages. The macrophage-specific metabolite itaconate promotes growth in several types of cancer; however,
Katharina M. Scheurlen, Jacob Hallion, Dylan L. Snook, Anne MacLeod, Robert J. Beal, Mary A. Parks, Andrew B. Littlefield, Eliah Hiken, Adrian T. Billeter, Jeannette Bensen, Jeremy T. Gaskins, Julia Chariker, Eric C. Rouchka, Susan Galandiuk   +13 more
doaj   +1 more source

Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice

The Journal of Clinical Investigation
Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the enzyme that synthesizes it, aconitate decarboxylase 1 (Acod1, also known as
Jianrui Song, Yanling Zhang, Ryan A. Frieler, Anthony Andren, Sherri Wood, Daniel J. Tyrrell, Peter Sajjakulnukit, Jane C. Deng, Costas A. Lyssiotis, Richard M. Mortensen, Morgan Salmon, Daniel R. Goldstein   +11 more
doaj   +1 more source

CpG-oligodeoxynucleotides challenged macrophages ameliorate acetaminophen induced liver injury by activating TLR9/IRG1/itaconate metabolic pathway

Molecular Medicine
Background Acetaminophen, or N-acetyl-para-aminophenol (APAP), causes severe liver damage and acute liver failure when overdosed. Oligodeoxynucleotides containing CpG motifs (CpG ODN) can regulate the function of macrophages, which play an important role
Yibai Qu, Zehui Jiang, Zhixia Chen, Sidan Luo, Bingyao Xie, Xubo Wu, Gang Yuan, Kan Wu, Li Chen, Tian Tian, Shan Li, Haihua Luo, Quan Li, Ding Yuan, Yan Zhang, Yanxia Gao, Jun Zhou, Zhengzheng Yan, Yong Jiang   +18 more
doaj   +1 more source

Dihydroartemisinin Promotes N1 Polarization of Tumor-Associated Neutrophils and Enhances Their Anti-Tumor Activity via Hub Gene Modulation

Pharmaceuticals
Background: Tumor-associated neutrophils (TANs) exhibit remarkable functional plasticity within tumor microenvironment (TME), with N1-like subtypes promoting anti-tumor immunity and N2-like subtypes facilitating tumor progression.
Wenjia Guo, Yu’e Liu, Wencong Ma, Jinghan Wang, Bingdi Chen, Lieying Fan   +5 more
doaj   +1 more source

Itaconate suppresses neonatal intestinal inflammation via metabolic reprogramming of M1 macrophage

Clinical and Translational Medicine
Background Necrotizing enterocolitis (NEC) is a rapidly progressive and severe gastrointestinal disorder in neonates that is marked by an inflammatory cascade initiated by mechanisms that remain incompletely understood, resulting in intestinal necrosis ...
Shuchen Huangfu, Chaoting Lan, Sitao Li, Huijuan Wang, Chun Yan, Yuling Yang, Bowen Tian, Yide Mu, Peizhi Zhao, Yan Tian, Yijia Wang, Wei Zhong, Limei Zhong, Yongyan Shi, Yufeng Liu   +14 more
doaj   +1 more source

The Influence of tert-Butylhydroquinone (TBHQ) on ACOD1/IRG1-Driven Inflammatory Pathways

The demand for processed foods has led to increased use of synthetic phenolic antioxidants (SPAs), notably tert-butylhydroquinone (TBHQ), to inhibit lipid oxidation and prolong shelf life.
Whisel, Alyssa M
core  

Offense and defense: itaconate mediates bidirectional immune regulation of host-bacteria interaction. [PDF]

J Biomed Sci
Men Z, Lin Z, Wang Z, Tan P, Yu S, Ma X.
europepmc   +1 more source

Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1

Metastasis causes breast cancer-related mortality. Tumor-infiltrating neutrophils (TINs) inflict immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance immunotherapy, yet it remains a challenge to identify therapeutic ...
Anna Huron (17776256), Eun Suh Sung (17776193), Zhongshun Liu (9193544), Guoqiang Liu (444582), Toni Mayberry (17776259), Ziyu Zeng (8946179), Yuting Zhang (9564266), Yujue Wang (213622), Hope Baldwin (17776253), Jessica Weaver (3464348), Keegan Gilbert (17776230), Yun Zhao (48978), Xuemin Lu (1516687), Qingfei Wang (1419130), Jun Li (6494), Sheng Liu (279488), M. Sharon Stack (4445767), Jun Wan (126294), Maria Elena Diaz-Rubio (6613256), Xin Lu (24821), Xiaoyang Su (1306557), Siyuan Zhang (2044930), Xiaoxia Peng (142430), Chi Zhang (9857), Dailin Gan (17776106), Yini Zhu (15385409), Wennan Chang (12355921), Ryan D. Sheldon (11232188), Xuechun Wang (8504442), Guanzhu Ren (17776255)   +29 more
core   +1 more source