Results 71 to 80 of about 1,632 (144)
Communications BiologySleepiness is commonly associated with neuroinflammation; however, the underlying neuroregulatory mechanisms remain unclear. Previous research suggests that the paraventricular thalamus (PVT) plays a crucial role in regulating sleep‐wake dynamics; thus ...
Jianjun Chang +6 more
doaj +1 more source
Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines
Advanced Functional Materials, Volume 36, Issue 66, 17 August 2026.Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang +13 more
wiley +1 more source
Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice
, 2022 ObjectiveThe intersection between immunology and metabolism contributes to the pathogenesis of obesity‐associated metabolic diseases as well as molecular control of inflammatory responses.
Jianrui Song +13 more
core +1 more source
, 2021 Wild-type and Acod1-/- C57BL/6 mice were intranasally infected with 107 CFU of wild-type mCherry expressing B. abortus 2308. At 9 days post-infection, mice were sacrificed and lungs were harvested. Lungs were fixed and embedded. 5 μm-thick slides of were
Mégane Van Gysel (11436992) +16 more
core +1 more source
Metabolic Regulation of Macrophages in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang +6 more
wiley +1 more source
Macrophage: Biological Functions, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 8, August 2026.Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun +4 more
wiley +1 more source
The Role of Aconitate Decarboxylase 1 in Inflammation and Disease
, 2022 Immune cell metabolism, or immunometabolism, has recently become of interest for its role in inflammation and disease. A growing field of research has identified that metabolic rewiring and immune cell activation are intimately connected, however the ...
Vigil, Thomas
core +1 more source
Veterinary Dermatology, Volume 37, Issue 4, Page 478-487, August 2026.Background: Vesicular cutaneous lupus erythematosus (VCLE) is a rare autoimmune disease in dogs and is considered the canine counterpart of human subacute cutaneous lupus erythematosus (SCLE). However, the molecular mechanisms underlying VCLE remain incompletely defined.
Treasa Clifford +5 more
wiley +1 more source
, 2022 A-C. Effect of endogenous ACOD1. BMDMs from WT or Acod1-/- C57BL/6N mice were preincubated with DI (0.25 mM) for 6 h, infected with IAV (PR8M, MOI = 1) or stimulated with IFN-γ (15 ng/ml) for 2 h, and then subjected to post-infection/stimulation ...
Mahmoud Shehata (9574695) +20 more
core +1 more source
Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes
Advanced Science, Volume 13, Issue 31, 4 June 2026.This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang +8 more
wiley +1 more source