Results 51 to 60 of about 1,632 (144)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

z‐VAD‐FMK triggers macrophage necroptosis during mycobacterial infection via a non‐canonical off‐target mechanism

mLife, EarlyView.
Abstract Macrophages are the predominant cell type infected by Mycobacterium tuberculosis (Mtb) in tuberculosis (TB). Death of Mtb‐infected macrophages promotes tissue pathology and releases Mtb to infect other cells, suggesting that inhibiting the death of Mtb‐infected macrophages could be an adjunctive treatment of TB.
Rong Hu, Pei Li, Jie Han, Jiamin Huang, Guoyi Huang, Xiuju Jiang, Daniel Pfau, Guobao Li, Yi‐Nan Gong, Carl F. Nathan, Li Zhang   +10 more
wiley   +1 more source

Acod1 gene deficiency does not affect does not affect splenomegaly induced following Brucella infection.

, 2021
Wild-type and Acod1-/- C57BL/6 mice were intranasally infected with 107 CFU of wild-type B. melitensis 16M or B. abortus 2308, as indicated. At 2-, 5-, 9- and 28-days post-infection, spleen were harvested and weighed individually.
Mégane Van Gysel (11436992), Véronique Flamand (488613), Stanislas Goriely (365243), Johan Wouters (49810), Abdulkader Azouz (8267025), Xavier De Bolle (6943391), Jan Abendroth (278420), Audrey Comein (11436986), Elodie Carlier (6535262), Justine Smout (11436989), Arnaud Machelart (176325), Thomas E. Edwards (9682), Aurore Demars (5618984), Armelle Vitali (11436983), Eik Hoffmann (80515), Priscille Brodin (57030), Eric Muraille (176330)   +16 more
core   +1 more source

A Multidimensional Framework for Interpreting Macrophage Markers in the Era of Cellular Heterogeneity

Immunology, EarlyView.
Macrophage markers should be interpreted as context‐dependent biological readouts rather than deterministic cell identifiers. This Review proposes a multidimensional framework integrating lineage, identity, and functional state across complementary experimental modalities to enable a more accurate interpretation of macrophage heterogeneity.
Alessandro Palma
wiley   +1 more source

Acod1/itaconate activates Nrf2 in pulmonary microvascular endothelial cells to protect against the obesity-induced pulmonary microvascular endotheliopathy

Respiratory Research
Background Obesity is the main risk factor leading to the development of various respiratory diseases, such as asthma and pulmonary hypertension. Pulmonary microvascular endothelial cells (PMVECs) play a significant role in the development of lung ...
Li Zhu, Zhuhua Wu, Yingli Liu, Yue Ming, Pei Xie, Miao Jiang, Yong Qi   +6 more
doaj   +1 more source

4‐Octyl Itaconate Attenuates Age‐Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
4‐Octyl itaconate (4‐OI) attenuates age‐induced parotid gland dysfunction through the suppression of fibrosis and lipid deposition by AMPKα/PPARα and the inhibition of oxidative stress via the AMPKα/Nrf2 signaling pathway. 4‐OI activates AMPKα, which in turn stimulates both the PPARα and Nrf2 pathways. Activation of PPARα enhances FAO and reduces lipid
Yun Chen, Tianyuan Gong, Zhongyan Shan, Jing Lai, Yiming Xu, Han Zhao, Lilei Zhu   +6 more
wiley   +1 more source

Induction of ACOD1 and TNFAIP3 mRNAs during IAV (H3N2) infection of human lung explants.

, 2022
Reanalysis of a published dataset of gene expression (RNAseq) in IAV A/Panama/2007/1999 (H3N2) infection (dose not specified) of human lung tissue derived from tumor-free margins obtained during lobectomy for lung carcinoma (39).
Mahmoud Shehata (9574695), Mohamed Tantawy (11944887), Heike Bähre (519434), Thomas Ebensen (198767), Kristin Schultz (6078449), Carlos A. Guzman (5650249), Stephan Pleschka (85578), Klaus Schughart (150782), Nishika Sahini (668877), Ahmed Mostafa (354419), Moritz Winterhoff (11944893), Matthias Preusse (3548096), Alessandro Michelucci (1806310), Azeem A. Iqbal (4991969), Fangfang Chen (302428), Christine Falk (109913), Robert Geffers (23730), Marina C. Pils (7388180), Frank Pessler (52000), Aaqib Sohail (11944884), Syed F.H. Waqas (12091126)   +20 more
core   +1 more source

Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide‐Induced Lung Injury in Obesity

Advanced Science
To investigate the mechanisms behind the worsening of acute lung injury (ALI) in obesity, transcriptomic sequencing is performed, and significantly reduced mRNA levels of Aconitate Decarboxylase 1 (ACOD1) in the lung tissue of high‐fat diet (HFD) mice ...
Jingyue Ma, Yichan Ao, Zhen Yue, Zhiqiao Wang, Xiangyu Hou, Hongbin Li, Hanbing Wang, Siqing Luo, Jianyu He, Zikun Duan, Ling Liu, Ke Wei   +11 more
doaj   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Acod1 deficiency does not affect the growth of ΔaceA B. abortus in vivo.

, 2021
Wild-type and Acod1-/- C57BL/6 mice were intranasally infected with 107 CFU of wild-type or ΔaceA mCherry expressing B. abortus 2308, as indicated. At 9 days post infection, mice were sacrificed, lungs were harvested and CFU were counted.
Mégane Van Gysel (11436992), Véronique Flamand (488613), Stanislas Goriely (365243), Johan Wouters (49810), Abdulkader Azouz (8267025), Xavier De Bolle (6943391), Jan Abendroth (278420), Audrey Comein (11436986), Elodie Carlier (6535262), Justine Smout (11436989), Arnaud Machelart (176325), Thomas E. Edwards (9682), Aurore Demars (5618984), Armelle Vitali (11436983), Eik Hoffmann (80515), Priscille Brodin (57030), Eric Muraille (176330)   +16 more
core   +1 more source