Results 31 to 40 of about 1,632 (144)

Dual itaconate delivery systems modulate macrophage Acod1-Hif-1α-glycolysis axis for immunotherapy of bioprosthetic heart valve calcification [PDF]

Bioactive Materials
Calcification remains a major barrier to the long-term durability of bioprosthetic heart valves (BHVs), yet effective therapeutic strategies are still lacking.
Shuyu Wen, Junwei Zhang, Ying Zhou, Jinchi Zhang, Chao Zhang, Chunli Wang, Yixuan Wang, Zongtao Liu, Yin Xu, Bohao Jian, Hong Cao, Shijie Wang, Xing Liu, Yunlong Wu, Jiawei Shi, Fei Li, Kang Xu, Weihua Qiao, Nianguo Dong   +18 more
doaj   +2 more sources

Reciprocal interactions between Acod1 expression and inflammation during influenza A virus infection in mice.

, 2022
A. Higher pulmonary expression of Acod1, Tnfaip3, and Hmox1 and 2 mRNA in DBA/2J (D2) than in C57BL/6J (B6) mice following IAV infection (2x103 FFU PR8M; reanalysis of published RNAseq data [31]) (n = 3 each strain and time point).
Mahmoud Shehata (9574695), Mohamed Tantawy (11944887), Heike Bähre (519434), Thomas Ebensen (198767), Kristin Schultz (6078449), Carlos A. Guzman (5650249), Stephan Pleschka (85578), Klaus Schughart (150782), Nishika Sahini (668877), Ahmed Mostafa (354419), Moritz Winterhoff (11944893), Matthias Preusse (3548096), Alessandro Michelucci (1806310), Azeem A. Iqbal (4991969), Fangfang Chen (302428), Christine Falk (109913), Robert Geffers (23730), Marina C. Pils (7388180), Frank Pessler (52000), Aaqib Sohail (11944884), Syed F.H. Waqas (12091126)   +20 more
core   +1 more source

Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice.

PLoS Pathogens, 2021
Brucellosis is one of the most widespread bacterial zoonoses worldwide. Here, our aim was to identify the effector mechanisms controlling the early stages of intranasal infection with Brucella in C57BL/6 mice.
Aurore Demars, Armelle Vitali, Audrey Comein, Elodie Carlier, Abdulkader Azouz, Stanislas Goriely, Justine Smout, Véronique Flamand, Mégane Van Gysel, Johan Wouters, Jan Abendroth, Thomas E Edwards, Arnaud Machelart, Eik Hoffmann, Priscille Brodin, Xavier De Bolle, Eric Muraille   +16 more
doaj   +1 more source

Cytokine time-course in Bb stimulated Acod1-/- cells.

, 2023
Bone marrow derived macrophage from NJ WT and Acod1 deficient mice were stimulated with Bb MOI10 for 10, 24 and 48 hours. Supernatants were collected at each time point and cytokines measured by ELISA.
Linden T. Hu (13989808), Urmila Powale (17712203), Jennifer D. Helble (3270561), P. Kent Langston (17712206), Tanja Petnicki-Ocwieja (241386), Julie E. McCarthy (13989802)   +5 more
core   +1 more source

Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism [PDF]

, 2022
Although the immunomodulatory and cytoprotective properties of itaconate have been studied extensively, it is not known whether its naturally occurring isomers mesaconate and citraconate have similar properties.
Hirsch, A. K. H., Waqas, F.H., Sahini, N., Hirsch, A.K.H., Falk, C., Pessler, F., Büssow, K., Schuchardt, Sven, Vega, L. de la, Michelucci, A., Czichon, L., Pleschka, S., Zillinger, T., Elgaher, W.A.M., Shehata, M., de la Vega, L., Zobl, Walter, Blankenfeldt, W., Graner, E., de la Vega, L.; id_orcid, Elgaher, W. A.M., Casares Perez, L., Elgaher, W. A. M., Zobl, W., Winterhoff, M., Waqas, F. H., Bähre, H., Chen, F., Pires-Afonso, Y., Schuchardt, S.   +29 more
core   +4 more sources

Acod1 is induced upon Bb stimulation.

, 2023
BMDMs were stimulated with Bb (MOI 10) for 0, 6 and 24 hours. Cells were collected and protein expression levels of Acod1 were assessed by immunoblot with β-actin as a loading control. (TIFF)
Linden T. Hu (13989808), Urmila Powale (17712203), Jennifer D. Helble (3270561), P. Kent Langston (17712206), Tanja Petnicki-Ocwieja (241386), Julie E. McCarthy (13989802)   +5 more
core   +1 more source

Acod1 is a highly up-regulated modulator of inflammation.

, 2023
A) Volcano plot of DEGs in primary stimulation. Described negative regulators of inflammation are noted. B) Table of genes with known roles in negative regulation of innate immune responses found in our stimulated data set.
Linden T. Hu (13989808), Urmila Powale (17712203), Jennifer D. Helble (3270561), P. Kent Langston (17712206), Tanja Petnicki-Ocwieja (241386), Julie E. McCarthy (13989802)   +5 more
core   +1 more source

Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection.

PLoS Pathogens, 2022
Excessive inflammation is a major cause of morbidity and mortality in many viral infections including influenza. Therefore, there is a need for therapeutic interventions that dampen and redirect inflammatory responses and, ideally, exert antiviral ...
Aaqib Sohail, Azeem A Iqbal, Nishika Sahini, Fangfang Chen, Mohamed Tantawy, Syed F H Waqas, Moritz Winterhoff, Thomas Ebensen, Kristin Schultz, Robert Geffers, Klaus Schughart, Matthias Preusse, Mahmoud Shehata, Heike Bähre, Marina C Pils, Carlos A Guzman, Ahmed Mostafa, Stephan Pleschka, Christine Falk, Alessandro Michelucci, Frank Pessler   +20 more
doaj   +1 more source

Additional file 1 of Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression

, 2023
Additional file 1:  Sup Fig. 1. Sirt3 deficiency increased mitochondrial ROS production and nuclear localization of NF-kB P65in BMDMs treated with FAs + MSU crystals.
Yongen Xie (11145243), Long Ren (737700), Feng Chen (25347), Linxi Lv (16619943), Xiaoqin Zhou (3368027), Mei Zeng (293866), Hui Jiang (102809), Dianze Song (16619946)   +7 more
core   +1 more source

LCN2-ACOD1 Signalling Affects the Post-Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis [PDF]

Cell Proliferation
Jiayin Lu, Haidong Wang, Juan Wang
exaly   +2 more sources