Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response [PDF]
eLife, 2020 Particulate matter (PM) air pollution causes cardiopulmonary mortality via macrophage-driven lung inflammation; however, the mechanisms are incompletely understood.
Kaitlyn A Sun +7 more
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Divergent effects of itaconate isomers on Coxiella burnetii growth in macrophages and in axenic culture [PDF]
Frontiers in ImmunologyAconitate decarboxylase-1 (ACOD1) is expressed by activated macrophages and generates itaconate that exerts anti-microbial and immunoregulatory effects.
Md Nur A Alam Siddique +8 more
doaj +4 more sources
Obesity suppresses neutrophil-dependent itaconate signaling promoting ferroptosis in acute pancreatitis [PDF]
Redox BiologyObesity is a well-established risk factor for increased severity and mortality in acute pancreatitis. However, the mechanisms by which obesity alters pancreatic immune regulation and favors the progression of acute pancreatitis are not elucidated yet ...
Néstor Jiménez-Cañete +9 more
doaj +2 more sources
ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota [PDF]
Cell Death and DiseaseAconitate decarboxylase 1 (ACOD1) is the enzyme synthesizing itaconate, an immuno-regulatory metabolite tuning host-pathogen interactions. Such functions are achieved by affecting metabolic pathways regulating inflammation and microbe survival.
Tanja Eberhart +17 more
doaj +4 more sources
Neutrophil-based immunotherapy: A metabolic lens on mechanisms and therapeutic implications. [PDF]
Clin Transl MedTAN metabolic reprogramming critically contributes to tumour immune evasion. A 4‑Tier TAN‑MetaC classification framework is proposed, along with an overview of translational opportunities and bottlenecks for TAN metabolism‑targeted immunotherapies. Abstract Background Tumor‐associated neutrophils (TANs) serve as pivotal immune modulators in the tumor ...
Xu W, Su Y, Zhou L, Liu J, Guo J.
europepmc +2 more sources
Not all Group B Streptococci are alike: macrophage responses reveal inflammatory and immune-evasive strains [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundGroup B Streptococcus (GBS) remains a leading cause of neonatal sepsis and meningitis despite preventive strategies. Disease severity and clinical presentation vary widely and are influenced by strain-specific virulence traits.
Larisa Janžič +4 more
doaj +2 more sources
Itaconate ameliorates cardiovascular inflammation in a mouse model of Kawasaki disease vasculitis – brief report [PDF]
Frontiers in ImmunologyBackgroundKawasaki disease (KD), a systemic vasculitis and the leading cause of acquired heart disease in children, stems from an uncontrolled inflammatory response that fails to resolve in up to 20% of IVIG-treated patients.
Youngho Lee +16 more
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Itaconate: A Nexus Metabolite Fueling Leishmania Survival Through Lipid Metabolism Modulation
MicroorganismsLeishmaniasis, caused by the Leishmania parasite, is a neglected public health issue. Leishmania mainly infects macrophages, where metabolic reprogramming shapes their plasticity (M1/M2), affecting the host’s resistance or susceptibility to infection ...
Ayyoub Kihel +6 more
doaj +2 more sources
Advanced ScienceNeutrophil extracellular traps (NETs) are reticular structures released by neutrophils, and the process of their formation is called NETosis. NETs play a key role in the pathological process of sepsis.
Huifan Liu, Shujuan Wu
exaly +2 more sources
Human iPSC-derived alveolar macrophages reveal macrophage subtype functions of itaconate in M. tuberculosis defense [PDF]
JCI InsightMycobacterium tuberculosis (Mtb) survives within multiple macrophage populations during infection, including alveolar macrophages (AMs) and recruited inflammatory macrophages.
Adam S. Krebs +21 more
doaj +2 more sources