Results 11 to 20 of about 1,632 (144)

Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides

Cell Reports
Summary: Targeting programmed cell death protein 1 (PD-1) is an important component of many immune checkpoint blockade (ICB) therapeutic approaches.
Zachary Schafer
exaly   +5 more sources

ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion

Clinical and Translational Medicine
Background Spinal cord injury (SCI)‐induced neuroinflammation and oxidative stress (OS) are crucial events causing neurological dysfunction. Aconitate decarboxylase 1 (ACOD1) and its metabolite itaconate (Ita) inhibit inflammation and OS by promoting ...
Lei Yang, Zhanyang Qian, Haijun Li
exaly   +3 more sources

Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques

Redox Biology
Inflammatory macrophages are key drivers of atherosclerosis that can induce rupture-prone vulnerable plaques. Skewing the plaque macrophage population towards a more protective phenotype and reducing the occurrence of clinical events is thought to be a ...
Karl J Harber, Myrthe Den Toom, Linda Beckers   +2 more
exaly   +4 more sources

Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency [PDF]

Molecular Oncology, 2022
In glioblastoma (GBM), tumour‐associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment and contribute to tumour immune escape mechanisms.
Simone P Niclou, Carole Sousa, Alessandro Michelucci   +2 more
exaly   +3 more sources

Macrophages inhibit Coxiella burnetii by the ACOD1‐itaconate pathway for containment of Q fever [PDF]

EMBO Molecular Medicine, 2022
Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis‐aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as ...
Lisa Kohl, Md Nur A Alam Siddique, Barbara Bodendorfer, Raffaela Berger, Annica Preikschat, Christoph Daniel, Martha Ölke, Elisabeth Liebler‐Tenorio, Jan Schulze‐Luehrmann, Michael Mauermeir, Kai‐Ting Yang, Inaya Hayek, Manuela Szperlinski, Jennifer Andrack, Ulrike Schleicher, Aline Bozec, Gerhard Krönke, Peter J Murray, Stefan Wirtz, Masahiro Yamamoto, Valentin Schatz, Jonathan Jantsch, Peter Oefner, Daniel Degrandi, Klaus Pfeffer, Katja Mertens‐Scholz, Simon Rauber, Christian Bogdan, Katja Dettmer, Anja Lührmann, Roland Lang   +30 more
doaj   +2 more sources

Cepharanthine Alleviates DSS-Induced Ulcerative Colitis via Regulating Aconitate Decarboxylase 1 Expression and Macrophage Infiltration

Molecules, 2023
Cepharanthine (CEP), a bisbenzylisoquinoline alkaloid from tubers of Stephania, protects against some inflammatory diseases. Aconitate decarboxylase 1 (ACOD1) is also known as immune-responsive gene 1 (IRG1), which plays an important immunometabolism ...
Min-Na Zhang, Rui Xie, Hong-Gang Wang, Xin Wen, Jing-Yi Wang, Le He, Meng-Hui Zhang, Xiao-Zhong Yang   +7 more
doaj   +2 more sources

Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression

Arthritis Research & Therapy, 2023
Background Previous studies have revealed that Sirt3 deficiency is associated with several inflammatory responses. The purpose of this study is to investigate the role and potential molecular mechanisms of Sirt3 in the inflammation induced by monosodium ...
Linxi Lv, Hui Jiang, Dianze Song, Xiaoqin Zhou, Feng Chen, Long Ren, Yongen Xie, Mei Zeng   +7 more
doaj   +2 more sources

Stromal cell-derived itaconate promotes endometriosis via macrophage NRF2 and lysosomal pH modulation [PDF]

Redox Biology
Endometriosis (EM) is driven by immune dysregulation and macrophage dysfunction, yet the underlying mechanisms remain unclear. Here, metabolomic profiling revealed excessive itaconate accumulation in EM lesions, primarily due to elevated cis-aconitate ...
Zhaoyang Zhong, Shuang Wang, Qianhui Ren, Xue Jiao, Le Xu, Xiaoyu Dong, Na Li, Hongwei Guan, Ran Chu, Ming Yuan, Jincheng Liu, Yanbo Du, Keke Wei, Lei Yan, Guoyun Wang   +14 more
doaj   +2 more sources

Identification of a metabolic–immune crosstalk in Still’s disease: monocyte/macrophage-derived immunometabolite itaconate dictates hepatic immunopathology via the CXCL10–CD8 T cell axis [PDF]

Experimental and Molecular Medicine
Still’s disease (SD) is a chronic and systemic autoinflammatory disorder, with the possibility of resulting in life-threatening complications, including macrophage activation syndrome (MAS).
Junna Ye, Fan Wang, Zhuochao Zhou, Jinchao Jia, Ziang Wu, Yijun You, Nadiem Atiq, Yutong Su, Huihui Chi, Jianfen Meng, Mengyan Wang, Yuning Ma, Shirin Hosseini, Martin Korte, Jialin Teng, Chengde Yang, Karsten Hiller, Qiongyi Hu, Wei He, Yue Sun   +19 more
doaj   +2 more sources

Itaconate and its derivatives in human health and diseases [PDF]

Signal Transduction and Targeted Therapy
Metabolic reprogramming forms the foundation of immune effector functions and the regulation of inflammation. As a pivotal node connecting the tricarboxylic acid cycle to immune signaling, the IRG1/ACOD1 and itaconate axes play a central role in ...
Jianyou Gu, Wenying Zhang, Junfeng Zhang, Silue Zeng, Renpei Xia, Lei Cai, Xiaosheng Zhong, Shixiang Guo, Huaizhi Wang, Zhe-Sheng Chen   +9 more
doaj   +2 more sources