Results 1 to 10 of about 2,411 (155)

Neutrophil Irg1/itaconate axis protects against experimental colitis by suppressing local inflammation and maintaining hematopoietic homeostasis [PDF]

Molecular Biomedicine
Inflammatory bowel disease (IBD) is a chronic, relapsing disorder characterized by excessive inflammation and often associated with extraintestinal symptoms. Current treatments remain unsatisfactory. Although immune response gene 1 (Irg1) and its product
Yi Jia, Jining Gao, Tao Wang
exaly   +3 more sources

Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response

Genes and Diseases, 2023
Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect is not satisfactory. Immune responsive gene 1 (IRG1) is a highly expressed gene in macrophage in response to inflammatory response and catalyzes
Kaixiong Tao, Li Chengguo, Yaxin Wang
exaly   +5 more sources

IRG1–itaconate axis in immunometabolism: mechanistic roles and therapeutic potential in inflammatory diseases [PDF]

Frontiers in Immunology
Cells can produce various metabolites, and both immune cells and the immune microenvironment are profoundly influenced by these metabolites. By reshaping the metabolic state of immune cells via metabolites, the host immune response can be effectively ...
Yang Liu, Pengyu Zhang, Weijie Kong, Jinghui Li, Haoqiang Yang, Hengqi Bai, Gexu Fan, Xinfang Cao, Yanjun Li, Yanjun Li   +9 more
doaj   +5 more sources

Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis

Frontiers in Cellular and Infection Microbiology, 2022
Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue damage in ...
Eduardo Pinheiro Amaral, Alan Sher, Muthulekha Swamydas   +2 more
exaly   +3 more sources

Protective role of IRG1/itaconate in acute myocardial injury: association with NLRP3 inflammasome and oxidative stress [PDF]

Scientific Reports
Increasing evidence indicates the critical role of Immune response gene 1 (IRG1)-derived itaconate in metabolic regulation and signal transduction, with therapeutic implications for inflammatory diseases.
Hui Chen, Kerui Fan, Shu Xiang, Nian Zeng, Hui Wen, Jun Cai, Kun Chen, Xiaojiao He   +7 more
doaj   +2 more sources

A Scalable Organoid Model of Urothelial Aging for Metabolic Interrogation, Infection Modeling, and Reversal of Age-Associated Changes. [PDF]

Aging Cell
mBEDOs: a scalable platform for modeling urothelial aging. mBEDOs derived from aged mouse bladders capture essential molecular and cellular features of urothelial aging and provide a versatile system for high‐throughput metabolic profiling, therapeutic screening via metabolite supplementation, age‐ and sex‐based analyses, infection modeling, and immune–
Parab AR, Salazar AM, Bark SJ, Divenko M, Putluri V, Lieu DJ, Singh AS, Putluri N, Mysorekar IU.   +8 more
europepmc   +2 more sources

Itaconate and obesity-related hormones promote tumor progression – new insights on metabolic dysfunction in early-onset colon cancer [PDF]

Frontiers in Immunology
IntroductionObesity is a strong risk factor for early-onset colon cancer (EOCC) and is associated with chronic inflammation largely mediated by macrophages. The macrophage-specific metabolite itaconate promotes growth in several types of cancer; however,
Katharina M. Scheurlen, Jacob Hallion, Dylan L. Snook, Anne MacLeod, Robert J. Beal, Mary A. Parks, Andrew B. Littlefield, Eliah Hiken, Adrian T. Billeter, Jeannette Bensen, Jeremy T. Gaskins, Julia Chariker, Eric C. Rouchka, Susan Galandiuk   +13 more
doaj   +2 more sources

IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury

Frontiers in Immunology, 2022
Inflammation plays an important role in the occurrence and development of neuropathic pain. Immune-responsive gene 1 (IRG1) decarboxylates cis-aconitate to produce itaconate in the mitochondria.
Danmin Shen, Hu Tingting
exaly   +3 more sources

Itaconate Promotes Cold Adaptation and Myocardial Protection by Enhancing Brown Adipose Tissue Metabolism [PDF]

Metabolites
Background/Objectives: Itaconic acid (ITA) is an immunometabolite with anti-inflammatory and metabolic regulatory functions, but its cellular source and role in brown adipose tissue (BAT) remain unclear.
Zilong Geng, Xing Liu, Xiao Cheng, Shizhan Xu, Jin Zhang, Ao Tan, Shun Song, Shasha Zhang   +7 more
doaj   +2 more sources

Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3-Inflammasome Activation in Macrophages. [PDF]

FASEB J
Utilizing a clinically relevant course of treatment, our study reveals that glucocorticoids protect against the late NLRP3 inflammasome activation regulating the IL‐1β secretion, the processing of GSDM‐D and pyroptosis following signal 2 stimulation. These potent anti‐inflammatory effects are mediated by the activation of GR signaling and the expansion
Diaz-Jimenez D, Oakley RH, Hoffman JA, Bortner CD, Lih F, Li J, Williams JG, Scappini E, Gerrish KE, Garantziotis S, Archer TK, Cidlowski JA.   +11 more
europepmc   +2 more sources