Results 21 to 30 of about 2,411 (155)

Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane [PDF]

Signal Transduction and Targeted Therapy
Metabolic reprogramming of host cells plays critical roles during viral infection. Itaconate, a metabolite produced from cis-aconitate in the tricarboxylic acid cycle (TCA) by immune responsive gene 1 (IRG1), is involved in regulating innate immune ...
Shulei Yin, Yijie Tao, Tianliang Li, Chunzhen Li, Yani Cui, Yunyan Zhang, Shenhui Yin, Liyuan Zhao, Panpan Hu, Likun Cui, Yunyang Wu, Yixian He, Shu Yu, Jie Chen, Shaoteng Lu, Guifang Qiu, Mengqi Song, Qianshan Hou, Cheng Qian, Zui Zou, Sheng Xu, Yizhi Yu   +21 more
doaj   +2 more sources

IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1

Cell Reports
Summary: Perturbation of energy metabolism is an essential feature during infection and inflammation. TANK-binding kinase 1 (TBK1) is crucial for initiating the innate immune response against viral infection, although aberrant and ongoing TBK1 activation
Gao Jialin, Mutian Jia
exaly   +3 more sources

Mitochondrial ACOD1/IRG1 in infection and sterile inflammation

Journal of Intensive Medicine, 2022
Immunometabolism is a dynamic process involving the interplay of metabolism and immune response in health and diseases. Increasing evidence suggests that impaired immunometabolism contributes to infectious and inflammatory diseases. In particular, the mitochondrial enzyme aconitate decarboxylase 1 (ACOD1, best known as immunoresponsive gene 1 [IRG1 ...
Runliu Wu, Rui Kang, Daolin Tang
openaire   +2 more sources

Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8+ T-cell exhaustion

Nature Communications, 2023
Itaconate is a well-known immunomodulatory metabolite; however, its role in hepatocellular carcinoma (HCC) remains unclear. Here, we find that macrophage-derived itaconate promotes HCC by epigenetic induction of Eomesodermin (EOMES)-mediated CD8+ T-cell ...
Xuemei Gu, Haoran Wei, Caixia Suo, Shengqi Shen, Chuxu Zhu, Liang Chen, Kai Yan, Zhikun Li, Zhenhua Bian, Pinggen Zhang, Mengqiu Yuan, Yingxuan Yu, Jinzhi Du, Huafeng Zhang, Linchong Sun, Ping Gao   +15 more
doaj   +1 more source

Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury

Cell Death and Disease, 2023
Accumulating evidence indicates that metabolic responses are deeply integrated into signal transduction, which provides novel opportunities for the metabolic control of various disorders.
Kerui Fan, Kun Chen, Xinyan Zan, Ying Zhi, Xue Zhang, Xinyue Zhang, Jinghuan Qiu, Gang Liu, Longjiang Li, Li Tang, Kai Hu, Jingyuan Wan, Xianqiong Gong, Yongqiang Yang, Li Zhang   +14 more
doaj   +1 more source

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages. [PDF]

PLoS ONE, 2016
Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions. Its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an ...
Aravind Tallam, Thaneer M Perumal, Paul M Antony, Christian Jäger, Joëlle V Fritz, Laurent Vallar, Rudi Balling, Antonio Del Sol, Alessandro Michelucci   +8 more
doaj   +1 more source

Targeting IRG1 in tumor-associated macrophages for cancer therapy. [PDF]

Protein Cell
Liu S, Wei LX, Yu Q, Guo ZW, Zhan CY, Chen LL, Li Y, Ye D.   +7 more
europepmc   +3 more sources

Itaconate Suppresses the Activation of Mitochondrial NLRP3 Inflammasome and Oxidative Stress in Allergic Airway Inflammation

Antioxidants, 2023
Itaconate has emerged as a novel anti-inflammatory and antioxidative endogenous metabolite, yet its role in allergic airway inflammation (AAI) and the underlying mechanism remains elusive.
Qiu-Meng Xie, Ning Chen, Si-Ming Song, Cui-Cui Zhao, Ya Ruan, Jia-Feng Sha, Qian Liu, Xu-Qin Jiang, Guang-He Fei, Hui-Mei Wu   +9 more
doaj   +1 more source

The IRG1/itaconate/TFEB axis: A new weapon in macrophage antibacterial defense

Molecular Cell, 2022
Zhang et al. (2022) report that itaconate, a mitochondrial metabolite produced by macrophages upon inflammatory stimuli, activates the master regulator of lysosomal biogenesis TFEB to facilitate clearance of invading bacteria and efficient immune response.
José A, Martina, Rosa, Puertollano
openaire   +4 more sources

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

Cell Reports Medicine, 2021
Summary: The eye is highly susceptible to inflammation-mediated tissue damage evoked during bacterial infection. However, mechanisms regulating inflammation to protect the eye remain elusive.
Sukhvinder Singh, Pawan Kumar Singh, Alokkumar Jha, Poonam Naik, Joveeta Joseph, Shailendra Giri, Ashok Kumar   +6 more
doaj   +1 more source