Results 21 to 30 of about 2,835 (186)

The IRG1–itaconate axis protects from cholesterol-induced inflammation and atherosclerosis

Proceedings of the National Academy of Sciences
Atherosclerosis is fueled by a failure to resolve lipid-driven inflammation within the vasculature that drives plaque formation. Therapeutic approaches to reverse atherosclerotic inflammation are needed to address the rising global burden of ...
Schmidt, Ann Marie, van Solingen, Coen, Amadori, Letizia, Das, Dayasagar, Kaur, Ravneet, Zhang, Tracy, Dupuis, Samantha D., Moore, Kathryn J., Giannarelli, Chiara, Bozal, Fazli K., Gourvest, Morgane, Gildea, Michael, Sanchez, Bernard F., Wang, Kristin M., Fisher, Edward A., Newman, Alexandra A. C., Barcia Durán, José Gabriel, Schlegel, P. Martin, Cyr, Yannick, Smyrnis, Panagiotis, Von Itter, Richard, Cyr, Yannick;Bozal, Fazli K;Barcia Durán, José Gabriel;Newman, Alexandra A C;Amadori, Letizia;Smyrnis, Panagiotis;Gourvest, Morgane;Das, Dayasagar;Gildea, Michael;Kaur, Ravneet;Zhang, Tracy;Wang, Kristin M;Von Itter, Richard;Schlegel, P Martin;Dupuis, Samantha D;Sanchez, Bernard F;Schmidt, Ann Marie;Fisher, Edward A;van Solingen, Coen;Giannarelli, Chiara;Moore, Kathryn J   +21 more
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Identification of Bhlhe40 and Irg1 as essential regulators of the inflammatory response to Mycobacterium tuberculosis [PDF]

, 2018
Protective immune responses to Mycobacterium tuberculosis (Mtb) must induce bactericidal functions while minimizing damage to the lung. Such responses require precise control of pro- and anti-inflammatory factors to regulate the recruitment and function ...
Huynh, Jeremy Peter
core   +2 more sources

Heterologous expression of Mus musculus immunoresponsive gene 1 (irg1) in Escherichia coli results in itaconate production

Frontiers in Microbiology, 2015
Itaconic acid, a C5-dicarboxylic acid, is a potential biobased building block for the polymer industry. It is obtained from the citric acid cycle by decarboxylation of cis-aconitic acid.
Kiira S Vuoristo, Astrid E Mars, Stijn van eLoon, Enrico eOrsi, Gerrit eEggink, Johan P.M. Sanders, Ruud A Weusthuis   +6 more
doaj   +2 more sources

Identification of immune-responsive gene 1 (IRG1) as a target of A20

Journal of Proteome Research, 2018
A20 is a negative regulator of NF-kappa B signaling; it controls inflammatory responses and ensures tissue homeostasis. A20 is thought to restrict NF-kappa B activation both by its ubiquitin-editing activity as well as by its nonenzymatic activities ...
Goeminne, Ludger, Clement, Lieven, Kris Gevaert (64326), Van Quickelberghe, Emmy, Lieven Clement (203038), Kris Gevaert, van Loo, Geert, Martens, Arne, Ludger J. E. Goeminne (5210711), Arne Martens, Ludger J. E. Goeminne, Geert van Loo (181060), Arne Martens (5210714), Emmy Van Quickelberghe, Gevaert, Kris, Emmy Van Quickelberghe (3159576), Lieven Clement, Geert van Loo   +17 more
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The NF-κB/miR-378c/IRG1 axis drives tubular injury in septic AKI by suppressing immunometabolic protection

Renal Replacement Therapy
Background Septic acute kidney injury (AKI) is a life-threatening complication with high morbidity and mortality. Despite decades of research, therapeutic options remain limited to supportive care, underscoring the urgent need to decipher the molecular ...
Lu Zhou, Xiang Zhou, Hongmei Deng, Miaoyuan Zhang, Zheng Li   +4 more
doaj   +2 more sources

IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila [PDF]

mBio, 2019
Interferon gamma (IFN-γ) restricts the intracellular replication of many pathogens, but the mechanism by which IFN-γ confers cell-intrinsic pathogen resistance remains unclear.
Jordan V. Price, Daniel Russo, Daisy X. Ji, Roberto A. Chavez, Lucian DiPeso, Angus Yiu-Fai Lee, Jörn Coers, Russell E. Vance   +7 more
doaj   +2 more sources

Immune-responsive gene 1 (IRG1) and dimethyl itaconate are involved in the mussel immune response

Fish & Shellfish Immunology, 2020
11 pages, 8 figuresImmune-responsive gene 1 (irg1) is a gene that is well-conserved among different taxa and is highly expressed in the mussel Mytilus galloprovincialis at the constitutive level.
Saco, Amaro, Figueras Huerta, Antonio, Sendra, Marta, Rey-Campos, Magalí, Novoa, Beatriz   +4 more
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Reprogramming tumor-associated macrophages and blocking PD-L1 via engineered outer membrane vesicles to enhance T cell infiltration and cytotoxic functions [PDF]

Journal of Nanobiotechnology
The immunosuppressive tumor microenvironment (TME) critically undermines the efficacy of T cell-based tumor immunotherapy by impeding CD8+ T cell infiltration and cytotoxic function, primarily through tumor-associated macrophages (TAMs) and immune ...
Zhiqiang Chen, Bo Wang, Jianwei Zheng, Chao Liu, Peijun Xu, Qianqian Zhou, Jiayong Li, Zijian Shi, Zhenduo Wang, Xuyan Wang, Shunjin Xia, Fangquan Xu, Xiaofeng Yao, Yu Wang, Xinwei Wang, Xiao Zhao, Nana Ma, Yu Ren, Keman Cheng, Xuan Zhou   +19 more
doaj   +2 more sources

Early immune responses to systemic inflammation in the postnatal mouse brain initiated by migrating macrophages and leptomeningeal fibroblasts [PDF]

Journal of Neuroinflammation
Bacterial infection is a key trigger of inflammatory pathways that damage the preterm brain, even without direct bacterial brain invasion. However, the mechanisms underlying the involvement of intracranial tissues and cells in early immune responses to ...
Rei Settsu, Aki Obara, Takehiko Tarui, Sanae Hasegawa-Ishii, Atsuyoshi Shimada   +4 more
doaj   +2 more sources

Reconstruction of IRG1 Gene Regulatory Network in Mammalian Macrophages under Inflammatory Conditions

, 2015
The immune system is the first line of defence against invading pathogens. Macrophages are the key effector cells of the innate immune system which produce an array of cytokines, antimicrobial peptides, and effector molecules pathogen in response to ...
TALLAM, Aravind
core   +3 more sources