Results 11 to 20 of about 2,411 (155)

Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis

Cell Death and Disease, 2023
Hepatocarcinogenesis is initiated by repeated hepatocyte death and liver damage, and the underlying mechanisms mediating cell death and the subsequent carcinogenesis remain to be fully investigated.
Liyuan Zhang, Yue Dong, Luxin Zhang, Minjun Wang, Ye Zhou, Kaiwei Jia, Suyuan Wang, Mu Wang, Yunhui Li, Shudan Luo, Shan Lu, Yiwen Fan, Dingji Zhang, Yingyun Yang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +17 more
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Crystal Structure of an Active Site Mutant Form of IRG1 from Bacillus subtilis [PDF]

Crystals, 2021
Immune-responsive gene1 (IRG1), an enzyme that is overexpressed during immune reactions, catalyzes the production of itaconate from cis-aconitate. Itaconate is a multifunctional immuno-metabolite that displays antibacterial and antiviral activities.
Hyun Ho Park
doaj   +2 more sources

STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages

iScience, 2023
Summary: The liver is the main site of colorectal cancer (CRC) metastasis. Tumor-associated macrophages (TAMs) play a key role in tumor metastasis. Therefore, modulating the function of tumor-associated macrophages is a potential therapeutic strategy to ...
Yixuan Liu, Qi Sun, Chengfei Zhang, Min Ding, Cheng Wang, Qian Zheng, Zhijie Ma, Haojun Xu, Guoren Zhou, Xiaoming Wang, Zhangjun Cheng, Hongping Xia   +11 more
doaj   +3 more sources

Pomolic acid alleviates CCl4‑induced liver fibrosis in mice by suppressing β-arrestin 2-mediated pro-fibrotic macrophage polarization [PDF]

Scientific Reports
Liver fibrosis is a wound healing process in response to various chronic liver injuries characterized by the replacement of normal liver by collagen fibers formed from extracellular matrix (ECM), resulting in scarring of the organ.
Xuan Zhu, Yuhan Zhou, Mingyu Ruan, Xuebin Yang, Gang Pei, Jin Tan   +5 more
doaj   +2 more sources

IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury [PDF]

Cell Communication and Signaling
Immune response gene 1 (IRG1) is highly expressed in mitochondria of macrophages in a pro-inflammatory state. IRG1 and its metabolites play important roles in infection, immune-related diseases and tumor progression by exerting resistance of pathogens ...
Liwu Zeng, Yaxin Wang, Yongzhou Huang, Wenchang Yang, Pei Zhou, Yaqi Wan, Kaixiong Tao, Ruidong Li   +7 more
doaj   +2 more sources

Reprogramming tumor-associated macrophages and blocking PD-L1 via engineered outer membrane vesicles to enhance T cell infiltration and cytotoxic functions [PDF]

Journal of Nanobiotechnology
The immunosuppressive tumor microenvironment (TME) critically undermines the efficacy of T cell-based tumor immunotherapy by impeding CD8+ T cell infiltration and cytotoxic function, primarily through tumor-associated macrophages (TAMs) and immune ...
Zhiqiang Chen, Bo Wang, Jianwei Zheng, Chao Liu, Peijun Xu, Qianqian Zhou, Jiayong Li, Zijian Shi, Zhenduo Wang, Xuyan Wang, Shunjin Xia, Fangquan Xu, Xiaofeng Yao, Yu Wang, Xinwei Wang, Xiao Zhao, Nana Ma, Yu Ren, Keman Cheng, Xuan Zhou   +19 more
doaj   +2 more sources

Early immune responses to systemic inflammation in the postnatal mouse brain initiated by migrating macrophages and leptomeningeal fibroblasts [PDF]

Journal of Neuroinflammation
Bacterial infection is a key trigger of inflammatory pathways that damage the preterm brain, even without direct bacterial brain invasion. However, the mechanisms underlying the involvement of intracranial tissues and cells in early immune responses to ...
Rei Settsu, Aki Obara, Takehiko Tarui, Sanae Hasegawa-Ishii, Atsuyoshi Shimada   +4 more
doaj   +2 more sources

Exploring Functionally Enhanced BLP-Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance. [PDF]

Adv Sci (Weinh)
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Wan Y, Hong Y, Ji X, Xiang J, Liu J, Liang L, Ren M, Chen W, Xu T, Li Z, Shi T, Jiang Y, Liang H, Liu J.   +13 more
europepmc   +2 more sources

Itaconate-Related Gene Signatures as Prognostic Markers in Colon Cancer: Insights From Transcriptomic and Spatial Analysis. [PDF]

Hum Mutat
Colon cancer is one of the most prevalent malignant tumors. Accurate evaluation of patient prognosis and optimization of treatment strategies continue to be major research focuses in colon cancer. Based on The Cancer Genome Atlas (TCGA) database, this study is the first to comprehensively analyze the expression, biological roles, and prognosis of ...
Zhang T, Meng J, Wang Q, Zhang P, Li H, Wei H, Chen D, Bai C, Nair S.   +8 more
europepmc   +2 more sources

CpG-oligodeoxynucleotides challenged macrophages ameliorate acetaminophen induced liver injury by activating TLR9/IRG1/itaconate metabolic pathway [PDF]

Molecular Medicine
Background Acetaminophen, or N-acetyl-para-aminophenol (APAP), causes severe liver damage and acute liver failure when overdosed. Oligodeoxynucleotides containing CpG motifs (CpG ODN) can regulate the function of macrophages, which play an important role
Yibai Qu, Zehui Jiang, Zhixia Chen, Sidan Luo, Bingyao Xie, Xubo Wu, Gang Yuan, Kan Wu, Li Chen, Tian Tian, Shan Li, Haihua Luo, Quan Li, Ding Yuan, Yan Zhang, Yanxia Gao, Jun Zhou, Zhengzheng Yan, Yong Jiang   +18 more
doaj   +2 more sources