Results 11 to 20 of about 2,835 (186)

Crystal Structure of an Active Site Mutant Form of IRG1 from Bacillus subtilis [PDF]

Crystals, 2021
Immune-responsive gene1 (IRG1), an enzyme that is overexpressed during immune reactions, catalyzes the production of itaconate from cis-aconitate. Itaconate is a multifunctional immuno-metabolite that displays antibacterial and antiviral activities.
Hyun Ho Park
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Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis

Cell Death and Disease, 2023
Hepatocarcinogenesis is initiated by repeated hepatocyte death and liver damage, and the underlying mechanisms mediating cell death and the subsequent carcinogenesis remain to be fully investigated.
Liyuan Zhang, Yue Dong, Luxin Zhang, Minjun Wang, Ye Zhou, Kaiwei Jia, Suyuan Wang, Mu Wang, Yunhui Li, Shudan Luo, Shan Lu, Yiwen Fan, Dingji Zhang, Yingyun Yang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +17 more
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The Role of IRG1 in Atherosclerosis [PDF]

, 2023
Atherosclerosis is a primary contributing factor to heart attacks and strokes which are the leading cause of death on a global scale. This disease is characterised by the accumulation of lipids and macrophages in the artery walls.
HAASE, Lara
core   +3 more sources

CpG-oligodeoxynucleotides challenged macrophages ameliorate acetaminophen induced liver injury by activating TLR9/IRG1/itaconate metabolic pathway [PDF]

Molecular Medicine
Background Acetaminophen, or N-acetyl-para-aminophenol (APAP), causes severe liver damage and acute liver failure when overdosed. Oligodeoxynucleotides containing CpG motifs (CpG ODN) can regulate the function of macrophages, which play an important role
Yibai Qu, Zehui Jiang, Zhixia Chen, Sidan Luo, Bingyao Xie, Xubo Wu, Gang Yuan, Kan Wu, Li Chen, Tian Tian, Shan Li, Haihua Luo, Quan Li, Ding Yuan, Yan Zhang, Yanxia Gao, Jun Zhou, Zhengzheng Yan, Yong Jiang   +18 more
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Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages. [PDF]

PLoS ONE, 2016
Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions. Its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an ...
Aravind Tallam, Thaneer M Perumal, Paul M Antony, Christian Jäger, Joëlle V Fritz, Laurent Vallar, Rudi Balling, Antonio Del Sol, Alessandro Michelucci   +8 more
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Evaluating the role of IRG1 and itaconate on Marek's Disease virus infection

, 2022
Parcells, Mark S.Marek’s Disease (MD) is an oncogenic pathology of chickens characterized by paralysis, immune suppression, and the induction of T-cell lymphomas.
Wisser, Kristy
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Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection [PDF]

Journal of Experimental Medicine, 2018
Immune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions, principally in cells of myeloid lineage. Cell culture studies suggest that itaconate regulates inflammation through its inhibitory effects on
Schwarzkopf, Elizabeth A, Nair, Sharmila, Jeremy P. Huynh, Elizabeth A. Schwarzkopf, Adrianus C.M. Boon, Gounder, Anshu P, Bradstreet, Tara R, Vicky Lampropoulou, Sharmila Nair, Stallings, Christina L, Huynh, Jeremy P, Ekaterina Loginicheva, Boon, Adrianus C. M., Edelson, Brian T, Artyomov, Maxim N, Christina L. Stallings, Lampropoulou, Vicky, Tara R. Bradstreet, Michael S. Diamond, Loginicheva, Ekaterina, Brian T. Edelson, Anshu P. Gounder, Diamond, Michael S, Ekaterina Esaulova, Esaulova, Ekaterina, Maxim N. Artyomov   +25 more
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Enzymatic reaction mechanism of cis-aconitate decarboxylase based on the crystal structure of IRG1 from Bacillus subtilis

Scientific Reports, 2020
Itaconate, which is formed by decarboxylation of cis-aconitate—an intermediate metabolite in the tricarboxylic acid cycle—has been used as a building block in polymer synthesis and is an important chemical in several biomedical and industrial ...
Hye Lin Chun, So Yeon Lee, Sung Hoon Lee, Chang Sup Lee, Hyun Ho Park   +4 more
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STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages

iScience, 2023
Summary: The liver is the main site of colorectal cancer (CRC) metastasis. Tumor-associated macrophages (TAMs) play a key role in tumor metastasis. Therefore, modulating the function of tumor-associated macrophages is a potential therapeutic strategy to ...
Yixuan Liu, Qi Sun, Chengfei Zhang, Min Ding, Cheng Wang, Qian Zheng, Zhijie Ma, Haojun Xu, Guoren Zhou, Xiaoming Wang, Zhangjun Cheng, Hongping Xia   +11 more
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Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury

Cell Death and Disease, 2023
Accumulating evidence indicates that metabolic responses are deeply integrated into signal transduction, which provides novel opportunities for the metabolic control of various disorders.
Kerui Fan, Kun Chen, Xinyan Zan, Ying Zhi, Xue Zhang, Xinyue Zhang, Jinghuan Qiu, Gang Liu, Longjiang Li, Li Tang, Kai Hu, Jingyuan Wan, Xianqiong Gong, Yongqiang Yang, Li Zhang   +14 more
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