Results 41 to 50 of about 2,411 (155)

Characterization of chicken spleen transcriptome after infection with Salmonella enterica serovar Enteritidis. [PDF]

PLoS ONE, 2012
In this study we were interested in identification of new markers of chicken response to Salmonella Enteritidis infection. To reach this aim, gene expression in the spleens of naive chickens and those intravenously infected with S.
Marta Matulova, Jana Rajova, Lenka Vlasatikova, Jiri Volf, Hana Stepanova, Hana Havlickova, Frantisek Sisak, Ivan Rychlik   +7 more
doaj   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection [PDF]

Journal of Experimental Medicine, 2018
Immune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions, principally in cells of myeloid lineage. Cell culture studies suggest that itaconate regulates inflammation through its inhibitory effects on cytokine and reactive oxygen species production.
Sharmila Nair, Jeremy P. Huynh, Vicky Lampropoulou, Ekaterina Loginicheva, Ekaterina Esaulova, Anshu P. Gounder, Adrianus C.M. Boon, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Brian T. Edelson, Maxim N. Artyomov, Christina L. Stallings, Michael S. Diamond   +12 more
openaire   +3 more sources

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Pulsed-Ultrasound Irradiation Induces the Production of Itaconate and Attenuates Inflammatory Responses in Macrophages

Journal of Inflammation Research, 2022
Atomu Yamaguchi,1 Noriaki Maeshige,1 Xiaoqi Ma,1 Mikiko Uemura,1 Hikari Noguchi,1 Mami Matsuda,2 Yuya Nishimura,2 Tomohisa Hasunuma,2,3 Hiroyo Kondo,4 Hidemi Fujino1 1Department of Rehabilitation Science, Kobe University Graduate School of Health ...
Yamaguchi A, Maeshige N, Ma X, Uemura M, Noguchi H, Matsuda M, Nishimura Y, Hasunuma T, Kondo H, Fujino H   +9 more
doaj  

Notch3/4 Knockdown Inhibits Colon Adenocarcinoma Progression by Suppressing Tumor Cell Activity and Orchestrating VEGFA‐Dependent Tumor Immune Microenvironment

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Colon adenocarcinoma (COAD) is a prevalent gastrointestinal malignancy characterized by dysregulation of multiple cellular signaling pathways, including the Notch pathway. However, the specific biological roles of Notch3 and Notch4 in COAD remain incompletely characterized.
Wei Liu, Guhang Tang, Ningfu Li, Jiasheng Wang, Han Zhao, Chong Li   +5 more
wiley   +1 more source

4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

Cell Reports, 2023
Summary: The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins.
Weizhen Li, Yangguang Li, Jiaqi Kang, Haiyang Jiang, Wenbin Gong, Lijuan Chen, Cunxia Wu, Mingda Liu, Xiuwen Wu, Yun Zhao, Jianan Ren   +10 more
doaj   +1 more source

Boosting mRNA cancer vaccine efficacy via targeting Irg1 on macrophages in lymph nodes. [PDF]

Theranostics
Rationale: mRNA cancer vaccines show great promise for tumor therapy, but the therapeutic efficacy is limited. Metabolites play critical roles in immunomodulation. However, their role in mRNA cancer vaccines remains poorly understood. Methods: Metabolome analysis and single-cell RNA sequence were performed to explore the most important metabolite and ...
Wei W, Yang X, Chen Y, Che M, Ye Y, Deng Y, Su M, Sun Y, Meng J, Hu Y, Wang J, Wang Y, Feng Z, Zhou Z, Li Y, Li Q, Zhang Z, Wu B, Zhang H, Qin Y, Wen L, Wan C, Yang K.   +22 more
europepmc   +3 more sources

Lipocalin‐2 Restores Mitochondrial and Antioxidant Adaptation in a Strain‐Specific Manner During LPS Induced Sepsis

Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.
ABSTRACT Sepsis induces profound metabolic and mitochondrial dysfunction, contributing to multiple organ injury and mortality. Lipocalin‐2 (Lcn2), an acute‐phase protein, regulates iron homeostasis and oxidative stress, but its impact on mitochondrial resilience remains poorly understood.
Vinita Kushwaha, Mrunmayee R. Kandalgaonkar, Sukhvinder Singh, Piu Saha, Ashok Kumar, Beng San Yeoh, Matam Vijay‐Kumar   +6 more
wiley   +1 more source

The IRG1–itaconate axis protects from cholesterol-induced inflammation and atherosclerosis

Proceedings of the National Academy of Sciences
Atherosclerosis is fueled by a failure to resolve lipid-driven inflammation within the vasculature that drives plaque formation. Therapeutic approaches to reverse atherosclerotic inflammation are needed to address the rising global burden of cardiovascular disease (CVD).
Yannick Cyr, Fazli K. Bozal, José Gabriel Barcia Durán, Alexandra A. C. Newman, Letizia Amadori, Panagiotis Smyrnis, Morgane Gourvest, Dayasagar Das, Michael Gildea, Ravneet Kaur, Tracy Zhang, Kristin M. Wang, Richard Von Itter, P. Martin Schlegel, Samantha D. Dupuis, Bernard F. Sanchez, Ann Marie Schmidt, Edward A. Fisher, Coen van Solingen, Chiara Giannarelli, Kathryn J. Moore   +20 more
openaire   +2 more sources