Results 41 to 50 of about 2,835 (186)

The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity

iScience, 2022
ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in response to toll-like receptor (TLR) signaling.
Feng Chen, Runliu Wu, Jiao Liu, Rui Kang, Jinbao Li, Daolin Tang   +5 more
openaire   +3 more sources

Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS

Scientific Reports, 2021
Itaconic acid is produced by immune responsive gene 1 (IRG1)-coded enzyme in activated macrophages and known to play an important role in metabolism and immunity.
Xiaoyang Zhu, Yangyang Guo, Zhigang Liu, Jingyi Yang, Huiru Tang, Yulan Wang   +5 more
doaj   +1 more source

Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst

Cell Reports, 2023
Summary: Neutrophils are critical in the host defense against Staphylococcus aureus, a major human pathogen. However, even in the setting of a robust neutrophil response, S. aureus can evade immune clearance. Here, we demonstrate that S.
Kira L. Tomlinson, Sebastián A. Riquelme, Swikrity Upadhyay Baskota, Marija Drikic, Ian R. Monk, Timothy P. Stinear, Ian A. Lewis, Alice S. Prince   +7 more
doaj   +1 more source

Mitochondrial accumulation of IRG1/CAD under pro-inflammatory conditions.

, 2016
(A) Immunofluorescence images show maximum projections from 11 confocal planes. Scale bars indicate 20μm. Additionally magnified image regions and 2x magnified inlets are highlighted with yellow boxes.
Christian Jäger (1806313), Paul M. Antony (1806316), Thaneer M. Perumal (1806319), Rudi Balling (47350), Joëlle V. Fritz (109646), Aravind Tallam (681393), Antonio del Sol (19263), Laurent Vallar (81902), Alessandro Michelucci (1806310)   +8 more
core   +1 more source

Image_1_Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis.tif

, 2022
Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue damage in ...
Alan Sher (26370), Katelyn McCann (12487585), Logan Fisher (12487582), Caio C. B. Bomfim (9544559), Daniel W. McVicar (8635110), Eduardo P. Amaral (9034274), Raj Chari (23305), Mahtab Moayeri (120194), André A. S. Correa (12487588), Lara Mittereder (738925), Maria R. D’Império Lima (12487594), Diego L. Costa (12487591), Jonathan M. Weiss (12069887), Sivaranjani Namasivayam (4230787), Muthulekha Swamydas (143226)   +14 more
core   +1 more source

Itaconic acid, a missing link in macrophage activation, is produced by IRG1

The FASEB Journal, 2013
Itaconic acid (ITA) is a metabolite produced by primary macrophages and cell lines derived from macrophages that is dramatically increased upon activation. ITA is synthesized by a cis‐aconitate decarboxylase (cADC). Sequence searches with a known fungal cADC show little homology to ORFs in mammalian cells.
Jiongjia Cheng, Delilah Jewel, Thomas C. Chiles, Boguslaw Stec, Mary Fedarko Roberts   +4 more
openaire   +1 more source

A Multidimensional Framework for Interpreting Macrophage Markers in the Era of Cellular Heterogeneity

Immunology, EarlyView.
Macrophage markers should be interpreted as context‐dependent biological readouts rather than deterministic cell identifiers. This Review proposes a multidimensional framework integrating lineage, identity, and functional state across complementary experimental modalities to enable a more accurate interpretation of macrophage heterogeneity.
Alessandro Palma
wiley   +1 more source

Characterization of chicken spleen transcriptome after infection with Salmonella enterica serovar Enteritidis. [PDF]

PLoS ONE, 2012
In this study we were interested in identification of new markers of chicken response to Salmonella Enteritidis infection. To reach this aim, gene expression in the spleens of naive chickens and those intravenously infected with S.
Marta Matulova, Jana Rajova, Lenka Vlasatikova, Jiri Volf, Hana Stepanova, Hana Havlickova, Frantisek Sisak, Ivan Rychlik   +7 more
doaj   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Image_2_Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis.tif

, 2022
Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue damage in ...
Alan Sher (26370), Katelyn McCann (12487585), Logan Fisher (12487582), Caio C. B. Bomfim (9544559), Daniel W. McVicar (8635110), Eduardo P. Amaral (9034274), Raj Chari (23305), Mahtab Moayeri (120194), André A. S. Correa (12487588), Lara Mittereder (738925), Maria R. D’Império Lima (12487594), Diego L. Costa (12487591), Jonathan M. Weiss (12069887), Sivaranjani Namasivayam (4230787), Muthulekha Swamydas (143226)   +14 more
core   +1 more source