Results 61 to 70 of about 2,835 (186)

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Mitochondrial IRG1 closely associates with LCVs.

, 2016
(A, B) Ifnar-/- BMMs overexpressing IRG1-GFP (green) were stained with mitotracker (red), fixed and nuclei were visualized by DAPI (blue) staining. Images represent maximum intensity projections of z-stacks of 10 individual 1.4 μm thick sections.
Achim D. Gruber (141051), Martin Witzenrath (167419), Christoph Tabeling (167413), Andrea Peter (2141830), Susanne Herold (384252), Andreas C. Hocke (789599), Bastian Opitz (334645), Anca Dorhoi (2141821), Mareike Kunze (2141824), Matthias Trost (1296696), Sammy Bedoui (538008), Brian D. Dill (161071), Andreas Nerlich (117772), Ian van Driel (2141827), Stefan Kempa (268488), Andrew S. Brown (110423), Leif E. Sander (156292), Christine Hoffmann (460724), Hubert Hilbi (72826), Olivia Kershaw (141049), Norbert Suttorp (167418), Jan Naujoks (154495), Hans-Joachim Mollenkopf (157038)   +22 more
core   +1 more source

IRG1 controls host responses to restrict Mycobacterium tuberculosis infection [PDF]

, 2019
Abstract Mycobacterium tuberculosis ( Mtb ), the pathogen causing human tuberculosis, has evolved multiple strategies to successfully prevent clearance by immune cells and to establish dissemination and long-term survival in the host.
Arnaud Machelart, Imène Belhaouane, Nathalie Deboosere, Isabelle Poncin, Jean-Paul Saint-André, Anne-Marie Pauwels, Ok-Ryul Song, Samuel Jouny, Carine Rouanet, Anaïs Poncet, Sabrina Marion, William Laine, Jérôme Kluza, Eric Muraille, Rudi Beyaert, Laleh Majlessi, Stéphane Canaan, Priscille Brodin, Eik Hoffmann   +18 more
openaire   +2 more sources

/itaconate activates Nrf2/HO-1 pathway and mitigates septic liver injury in mice

European Journal of Inflammation
Objectives: Immune-responsive gene 1 ( Irg1 )-catalyzed production of itaconate is a bioactive metabolite with antibacterial, anti-inflammatory and antioxidant properties.
Tingting Zhang, Kexin Li, Jinghuan Qiu, Li Zhang, Xiaoliang Wang, Qiuhong Zhang, Yin Qin, Jie Liu, Gang Liu   +8 more
doaj   +1 more source

Notch3/4 Knockdown Inhibits Colon Adenocarcinoma Progression by Suppressing Tumor Cell Activity and Orchestrating VEGFA‐Dependent Tumor Immune Microenvironment

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Colon adenocarcinoma (COAD) is a prevalent gastrointestinal malignancy characterized by dysregulation of multiple cellular signaling pathways, including the Notch pathway. However, the specific biological roles of Notch3 and Notch4 in COAD remain incompletely characterized.
Wei Liu, Guhang Tang, Ningfu Li, Jiasheng Wang, Han Zhao, Chong Li   +5 more
wiley   +1 more source

Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2

EBioMedicine, 2020
Absract: Background: Identifying effective drugs to suppress vascular inflammation is a promising strategy to delay the progression of abdominal aortic aneurysm (AAA).
Haoyu Song, Tong Xu, Xiaofei Feng, Yanxian Lai, Yang Yang, Hao Zheng, Xiang He, Guoquan Wei, Wangjun Liao, Yulin Liao, Lintao Zhong, Jianping Bin   +11 more
doaj   +1 more source

Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia.

PLoS Pathogens
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in which neutrophils play a critical role. Immune-responsive gene 1 (IRG1), responsible for itaconate production, has emerged as an important regulator of inflammation and infection,
Cui Wang, Jun Wen, Zijun Yan, Yujun Zhou, Zhande Gong, Ying Luo, Zhenkui Li, Kang Zheng, Haijun Zhang, Nan Ding, Chuan Wang, Cuiming Zhu, Yimou Wu, Aihua Lei   +13 more
doaj   +1 more source

Lipocalin‐2 Restores Mitochondrial and Antioxidant Adaptation in a Strain‐Specific Manner During LPS Induced Sepsis

Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.
ABSTRACT Sepsis induces profound metabolic and mitochondrial dysfunction, contributing to multiple organ injury and mortality. Lipocalin‐2 (Lcn2), an acute‐phase protein, regulates iron homeostasis and oxidative stress, but its impact on mitochondrial resilience remains poorly understood.
Vinita Kushwaha, Mrunmayee R. Kandalgaonkar, Sukhvinder Singh, Piu Saha, Ashok Kumar, Beng San Yeoh, Matam Vijay‐Kumar   +6 more
wiley   +1 more source

IRG1/Itaconate Axis as an Immunometabolic Regulator of Pulmonary Hypertension

Pulmonary hypertension (PH) is a progressive cardiopulmonary disease characterized by pulmonary vascular remodeling and right ventricular hypertrophy, with immune cell–mediated mechanisms playing a central role. Immune-Responsive Gene 1 (IRG1), which encodes the enzyme responsible for itaconate production in macrophages, has established functions in ...
Hesami, Golnaz, Justus Liebig University Giessen   +1 more
openaire   +2 more sources