Results 71 to 80 of about 2,835 (186)

OLFML3 Promotes IRG1 Mitochondrial Localization and Modulates Mitochondrial Function in Macrophages

International Journal of Biological Sciences
Olfactomedin-like protein 3 (OLFML3), belonging to olfactomedin (OLF) protein family, has poorly defined functions. Recent studies have reported the functions of OLFML3 in anti-viral immunity and tumorigenesis. In this study, we investigated the roles of OLFML3 in macrophages.
Yu, Qijun, Mei, Hong, Gu, Qian, Zeng, Ran, Li, Yanan, Zhang, Junjie, Gao, Chenxu, Fang, Hai, Qu, Jieming, Liu, Jia   +9 more
openaire   +2 more sources

IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury

Cell Communication and Signaling
Immune response gene 1 (IRG1) is highly expressed in mitochondria of macrophages in a pro-inflammatory state. IRG1 and its metabolites play important roles in infection, immune-related diseases and tumor progression by exerting resistance of pathogens ...
Liwu Zeng, Yaxin Wang, Yongzhou Huang, Wenchang Yang, Pei Zhou, Yaqi Wan, Kaixiong Tao, Ruidong Li   +7 more
doaj   +1 more source

Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model

Journal of Immunology Research, 2016
Ovarian cancer (OVCA) mainly disseminates in the peritoneal cavity. Immune functions are important to prevent OVCA progression and recurrence. The mechanism of immunosuppression, a hallmark of tumor progression, is not well understood.
Sa’Rah McNeal, Pincas Bitterman, Janice M. Bahr, Seby L. Edassery, Jacques S. Abramowicz, Sanjib Basu, Animesh Barua   +6 more
doaj   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Immune-response gene 1 deficiency aggravates inflammation-triggered cardiac dysfunction by inducing M1 macrophage polarization and aggravating Ly6Chigh monocyte recruitment

Biology Direct
The immune response gene 1 (IRG1) and its metabolite itaconate are implicated in modulating inflammation and oxidative stress, with potential relevance to sepsis-induced myocardial dysfunction (SIMD).
Song Shen, Jianhui Li, Zhonghai Wei, Yihai Liu, Lina Kang, Rong Gu, Xuan Sun, Biao Xu, QiaoLing Li   +8 more
doaj   +1 more source

Connexin Regulation and Modulation of Neural Stem Cell Differentiation Induced by Cell‐Permeable Itaconate

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
The immunometabolite itaconate modulates the connexin profile of neural stem cells, and it upregulates Cx36‐based channels, promoting the differentiation toward a neuronal phenotype. These effects were abolished by connexin blockade, supporting a role for itaconate in the neuroimmune axis in inflammatory and neurodegenerative disorders. ABSTRACT Neural
Simona Denaro, Simona Rosa Spina, Simona D'Aprile, Anna Gervasi, Filippo Torrisi, Carmela Parenti, Agata Zappalà, Nunzio Vicario, Rosalba Parenti   +8 more
wiley   +1 more source

Senescent Factors Suppress Innate Antiviral Immunity in Aged Mice via Two Distinct Mechanisms

Aging Cell, Volume 25, Issue 4, April 2026.
Four secreted factors from senescent cells, including GDF15, IGF1, IL1α, and IL6, cooperatively suppress antiviral innate immunity. GDF15/IGF1 trigger AKT‐MEK‐mediated inactivation of GSK3β, leading to suppression of the TBK1‐IRF3 axis, whereas IL1α/IL6 induce p52 and RelB to suppress transcription of antiviral genes.
Xu Zhang, Qi Zhang, Li Wang, Shu Li, Hong‐Bing Shu   +4 more
wiley   +1 more source

IRG1-itaconate axis regulates lung tumorigenesis via pentose phosphate pathway metabolism [PDF]

TAMs use different nutrients in different metabolic pathways to support their function during tumor development. Although there has been some progress in understanding TAM metabolism, the involvement of TAM metabolism in tumor growth and especially in ...
Mansouri, Siavash
core   +1 more source

4‐Octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders

Annals of Clinical and Translational Neurology
Objective Neuromyelitis optica spectrum disorders (NMOSD) are rare inflammatory astrocytic diseases of the central nervous system (CNS). The roles of immune response gene‐1 (IRG1) and the IRG1–itaconic acid–NLRP3 inflammatory pathway in the pathogenesis ...
Ting Li, Jia‐Wen Li, Ying‐Hui Qin, Riu Liu, Xiao‐Na Xu, Xiao Li, Li‐Min Li, Bin Feng, Li Yang, Chun‐Sheng Yang   +9 more
doaj   +1 more source

The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response

The Journal of Clinical Investigation, 2023
Pathogens and inflammatory conditions rapidly induce the expression of immune-responsive gene 1 (IRG1) in cells of myeloid lineage. IRG1 encodes an aconitate decarboxylase (ACOD1) that produces the immunomodulatory metabolite itaconate (ITA). In addition
Yi-Rong Zeng, Jun-Bin Song, Dezheng Wang, Zi-Xuan Huang, Cheng Zhang, Yi-Ping Sun, Gang Shu, Yue Xiong, Kun-Liang Guan, Dan Ye, Pu Wang   +10 more
doaj   +1 more source