Results 91 to 100 of about 2,835 (186)

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Immune-responsive gene 1: The mitochondrial key to Th17 cell pathogenicity in CNS autoimmunity. [PDF]

Proc Natl Acad Sci U S A
Pathogenic Th17 cells play crucial roles in CNS autoimmune diseases such as multiple sclerosis (MS), but their regulation by endogenous mechanisms remains unknown.
Nematullah M, Fatma M, Zhou G, Prajapati B, Rashid F, Ayasolla K, Ahmed ME, She R, Mir S, Zahoor I, Hoda N, Rattan R, Giri S.   +12 more
europepmc   +2 more sources

Nuclear Localization of IRG1 Modulates COX2 Expression and Prostaglandin Biosynthesis in Primary Human Macrophages 2308479

Introduction Immunometabolism within macrophages represents a dynamic process modulated by environmental factors and pathological conditions.
Abigail Pajulas, Chunlao Tang, Chuck Dorsey, Cindy Wang, Katie Acken, Jordan Yokubonus, Linda Chung, Andrew Grigdesby, Anne Mc-GettrickDillon, Luke Bourner, Jaiya Randhawa, Robert Benschop, Luke O’Neill, Ian Lamb, Junpeng Xiao, Anthony Cannon   +15 more
core   +1 more source

Targeted macrophage phagocytosis by Irg1/itaconate axis improves the prognosis of intracerebral hemorrhagic stroke and peritonitisResearch in context

EBioMedicine
Summary: Background: Macrophages are innate immune cells whose phagocytosis function is critical to the prognosis of stroke and peritonitis. cis-aconitic decarboxylase immune-responsive gene 1 (Irg1) and its metabolic product itaconate inhibit bacterial
Zhaoli Luo, Ziyang Sheng, Liye Hu, Lei Shi, Yichen Tian, Xiaochu Zhao, Wei Yang, Zhongnan Xiao, Danmin Shen, Weihua Wu, Ting Lan, Boqian Zhao, Xiaogang Wang, Nan Zhuang, Jian-Nan Zhang, Yamei Wang, Yabin Lu, Liyong Wang, Chenguang Zhang, Peipei Wang, Jing An, Fei Yang, Qian Li   +22 more
doaj   +1 more source

Boosting mRNA cancer vaccine efficacy via targeting Irg1 on macrophages in lymph nodes. [PDF]

Theranostics
Rationale: mRNA cancer vaccines show great promise for tumor therapy, but the therapeutic efficacy is limited. Metabolites play critical roles in immunomodulation. However, their role in mRNA cancer vaccines remains poorly understood. Methods: Metabolome analysis and single-cell RNA sequence were performed to explore the most important metabolite and ...
Wei W, Yang X, Chen Y, Che M, Ye Y, Deng Y, Su M, Sun Y, Meng J, Hu Y, Wang J, Wang Y, Feng Z, Zhou Z, Li Y, Li Q, Zhang Z, Wu B, Zhang H, Qin Y, Wen L, Wan C, Yang K.   +22 more
europepmc   +3 more sources

Type I and II IFNs modify the proteome of bacterial vacuoles to restrict infections via IRG1 [PDF]

, 2015
Die hier vorgestellte Studie untersucht systematisch die angeborene Immunabwehr gegen L. pneumophila auf Ebene des gesamten Wirtsorganismus, sowie auf molekularer Ebene in Alveolar- und Knochenmarksmakrophagen. Mittels in vivo Transkriptomanalysen werden
Naujoks, Jan
core   +1 more source

Transcripts of COL4A2, IRG1, MMP12 genes as potential biomarkers of bull sperm quality

Agrarian science
Relevance. The aim of this work is to validate three sperm transcripts of candidate genes COL4A2, IRG1, MMP12 obtained using RNA-Seq and correlation analysis of their expression levels with high and low sperm quality indicators of Holstein bulls.Methods. Eighteen samples of cryopreserved sperm ejaculate were studied.
O. Yu. Barkova, D. A. Starikova, I. V. Chistyakova, N. V. Pleshanov, A. V. Gabova   +4 more
openaire   +1 more source

4-Octyl itaconate attenuates renal tubular injury in db/db mice by activating Nrf2 and promoting PGC-1α-mediated mitochondrial biogenesis

Renal Failure
Objectives: The aim of this study was to investigate the mechanism of itaconate’s potential effect in diabetic kidney disease.Methods: Renal immune responsive gene 1 (IRG1) levels were measured in db/db mice and streptozotocin (STZ) + high-fat diet (HFD)-
Muqing Shao, Jiayao Chen, Fuwei Zhang, Qian Su, Xiaoqian Lin, Weiwei Wang, Caiyu Chen, Hongmei Ren, Shuo Zheng, Suocheng Hui, Si Qin, Yinxing Ni, Jian Zhong, Jian Yang   +13 more
doaj   +1 more source

IRG1 expression in human immune cells under pro-inflammatory conditions.

, 2016
RNA was extracted from (A) PBMCs-derived monocytes, (B) PBMCs-derived macrophages and (C) PBMCs-derived dendritic cells 6 hours after treatment with LPS (10μg/ml), TNFα (50ng/ml), IFNγ (10ng/ml) and LPS together with TNFα or IFNγ in independent donors ...
Christian Jäger (1806313), Paul M. Antony (1806316), Thaneer M. Perumal (1806319), Rudi Balling (47350), Joëlle V. Fritz (109646), Aravind Tallam (681393), Antonio del Sol (19263), Laurent Vallar (81902), Alessandro Michelucci (1806310)   +8 more
core   +1 more source

Enhanced itaconic acid secretion from macrophages mediates the protection of mesenchymal stem cell-derived exosomes on lipopolysaccharide-induced acute lung injury mice

Biology Direct
Background Alveolar macrophages (AMs) is critical to exacerbate acute lung injury (ALI) induced by lipopolysaccharide (LPS) via inhibiting inflammation, which could by shifted by mesenchymal stem cell-derived exosomes (MSC-exos).
Yanmei Wen, Zong’an Liang
doaj   +1 more source