Results 101 to 110 of about 2,835 (186)

Proposed metabolic function of immune-responsive gene 1 (IRG1) in terms of dendritic cell mediated immune suppression

, 2014
Dendritische Zellen (DCs) besitzen sowohl im angeborenen als auch im adaptiven Immunsystemwichtige Aufgaben und sind somit für eine normal funktionierende Immunabwehr unabdingbar. Die Erkennung eines Gefahrensignals, beispielsweise des Lipopolysaccharids
Knapp, Natalie Claudia
core  

Abstract Fri063: The IRG1–Itaconate Axis Suppresses IL-1–Dependent Hematopoietic Reprogramming in Atherosclerosis

Systemic inflammation is a key driver of atherosclerotic cardiovascular disease (ASCVD), in part via hypercholesterolemia-induced expansion of hematopoietic stem cells (HSC) that supply proinflammatory myeloid cells to infiltrate ...
Jose Gabriel Barcia Duran, Morgane Gourvest, Michael Gildea, Tarik Zahr, Tracy Zhang, Whitney Rubin, Coen van Solingen, Kathryn Moore, Richard Von Itter, Fazli Bozal, Alexandra Newman, Kristin Wang   +11 more
core   +1 more source

All possible paths from LPS to IRG1 from the contextualised network.

, 2016
(A) Mouse and (B) human networks hierarchical layouts after calculating all possible paths between LPS and IRG1 from the contextualised networks. IRF1, interferon regulatory factor 1; CEBPB, CCAAT/enhancer binding protein (C/EBP) beta; CEBPD, CCAAT ...
Christian Jäger (1806313), Paul M. Antony (1806316), Thaneer M. Perumal (1806319), Rudi Balling (47350), Joëlle V. Fritz (109646), Aravind Tallam (681393), Antonio del Sol (19263), Laurent Vallar (81902), Alessandro Michelucci (1806310)   +8 more
core   +1 more source

Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane

Signal Transduction and Targeted Therapy
Metabolic reprogramming of host cells plays critical roles during viral infection. Itaconate, a metabolite produced from cis-aconitate in the tricarboxylic acid cycle (TCA) by immune responsive gene 1 (IRG1), is involved in regulating innate immune ...
Shulei Yin, Yijie Tao, Tianliang Li, Chunzhen Li, Yani Cui, Yunyan Zhang, Shenhui Yin, Liyuan Zhao, Panpan Hu, Likun Cui, Yunyang Wu, Yixian He, Shu Yu, Jie Chen, Shaoteng Lu, Guifang Qiu, Mengqi Song, Qianshan Hou, Cheng Qian, Zui Zou, Sheng Xu, Yizhi Yu   +21 more
doaj   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage

, 2015
Itaconate is a nonamino organic acid exhibiting antimicrobial effects. It has been recently identified in cells of macrophage lineage as a product of an enzyme encoded by immunoresponsive gene 1 (Irg1), acting on the citric acid cycle intermediate cis ...
Kiss, Gergely, Tretter, László, Németh, Beáta, Ravasz, Dóra, Horváth, Gergő, Kacsó, Gergely, Iordanov, Iordan, Ádám, Veronika, Mócsai, Attila, Csete, Dániel, Daniel Adams, Csépányi-Kömi, Roland, Chinopoulos, Christos, Dóczi, Judit, Nagy, Ádám Miklós   +14 more
core   +1 more source

Abstracts From PVRI 2026 Dublin

Pulmonary Circulation, Volume 16, Issue 2, April 2026.
wiley   +1 more source

OPA1 orchestrates mitochondrial immunometabolic remodeling in alveolar macrophages through the TFEB-IRG1-NRF2 signaling axis during sepsis-associated lung injury

Sepsis-associated lung injury (SALI) remains a major cause of mortality in critically ill patients, yet effective therapies targeting the dysregulated inflammatory response are lacking.
Ruimin Lu, Zhenhua Zeng, Jie Wu, Yanan Liu, Tong Sha, Lulan Li, Maomao Sun, Gege Xu, Zhongqing Chen, Junrui Zhu, Qiaobing Huang, Yufan Lei, Chun Su   +12 more
core   +1 more source

Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2

Cell Communication and Signaling
Nasopharyngeal carcinoma (NPC) is a malignant tumor of epithelial origin in head and neck with high incidence rate in South China, Southeast Asia and North Africa.
Xiaowei Zhang, Shen’er Qian, Ping’an Wu, Benquan Yu, Danhui Yin, Xia Peng, Shisheng Li, Zian Xiao, Zuozhong Xie   +8 more
doaj   +1 more source

Dual proteomics of infected macrophages reveal bacterial and host players involved in the Francisella intracellular life cycle and cell to cell dissemination by merocytophagy

Scientific Reports
Bacterial pathogens adapt and replicate within host cells, while host cells develop mechanisms to eliminate them. Using a dual proteomic approach, we characterized the intra-macrophage proteome of the facultative intracellular pathogen, Francisella ...
Héloïse Rytter, Kevin Roger, Cerina Chhuon, Xiongqi Ding, Mathieu Coureuil, Anne Jamet, Thomas Henry, Ida Chiara Guerrera, Alain Charbit   +8 more
doaj   +1 more source