Results 121 to 130 of about 2,411 (155)

The NOTCH4-GATA4-IRG1 axis as a novel target in early-onset colorectal cancer

Cytokine & Growth Factor Reviews, 2022
The early onset of colorectal cancer (CRC) in individuals younger than 50 years is an emerging phenomenon, and obesity is a strong risk factor. Inflammatory mechanisms are mediated by immune cells, with macrophages and their phenotypical changes playing a significant role in CRC.
Katharina M, Scheurlen, Julia H, Chariker, Ziad, Kanaan, Andrew B, Littlefield, Joan B, George, Caden, Seraphine, Andre, Rochet, Eric C, Rouchka, Susan, Galandiuk   +8 more
openaire   +2 more sources

IRG1 prevents excessive inflammatory responses and cardiac dysfunction after myocardial injury

Biochemical Pharmacology, 2023
Acute myocardial infarction (MI) and chemotherapeutic drug administration can induce myocardial damage and cardiomyocyte cell death, and trigger the release of damage-associated molecular patterns (DAMPs) that initiate the aseptic inflammatory response.
Xuewen Duan, Meiling Hu, Linshan Yang, Sheng Zhang, Bo Wang, Tong Li, Yong Tan, Yingke Li, Xingguang Liu, Zhenzhen Zhan   +9 more
openaire   +2 more sources

Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy

Science Advances, 2023
Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA has been established in multiple pathogen models, but very little is known in cancer.
Gui-Qi Zhu, Xianjing Li, Wen-Wei Zhu
exaly   +3 more sources

The Proinflammatory Cytokine-Induced IRG1 Protein Associates with Mitochondria

Journal of Interferon & Cytokine Research, 2009
Interferon-gamma (IFN-gamma) and tumor necrosis factor (TNF) are essential cytokines for successful clearance of microbial infections. Activation of macrophages by synergistic effects of these cytokines leads to induction of antimicrobial effector systems like reactive oxygen and reactive nitrogen intermediates. Strikingly, IFN-gammaR(-/-) and TNFRp55(-
Degrandi, Daniel, Hoffmann, Reinhard, Beuter-Gunia, Cornelia, Pfeffer, Klaus   +3 more
openaire   +3 more sources

Role of IRG1 in Regulating Pro-inflammatory and Pro-labor Mediators in Human Myometrium

Reproductive Sciences, 2020
Preterm birth is a major contributor to neonatal deaths and associated long-term morbidities for the survivors, yet therapies remain elusive, given our incomplete understanding of the mechanisms driving human labor and delivery. Human labor is an inflammatory process, and we investigated whether IRG1 (immunoresponsive gene-1) plays a role in these ...
Martha Lappas, Ratana Lim, Lappas Martha   +2 more
exaly   +3 more sources

Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20

Journal of Proteome Research, 2018
A20 is a negative regulator of NF-κB signaling; it controls inflammatory responses and ensures tissue homeostasis. A20 is thought to restrict NF-κB activation both by its ubiquitin-editing activity as well as by its nonenzymatic activities. Besides its role in NF-κB signaling, A20 also acts as a protective factor inhibiting apoptosis and necroptosis ...
Emmy Van Quickelberghe, Arne Martens, Ludger J. E. Goeminne, Lieven Clement, Geert van Loo, Kris Gevaert   +5 more
openaire   +2 more sources

Abstract 1202: ERG344: A novel IRG1 inhibitor for the treatment of colon cancer

Cancer Research, 2021
Abstract Immune responsive gene 1 (Irg1) is an LPS-inducible gene within macrophages (MF) whose protein product is responsible for the synthesis of itaconate from aconitate through a break in the TCA cycle. Although primarily present in proinflammatory macrophages, IRG1 expression has been linked with certain cancers (glioblastoma ...
Adonia E. Papathanassiu, Francesca Lodi, Hong A. Vu, Diether Lambrechts   +3 more
openaire   +1 more source

IRG1/ACOD1 promotes neutrophil reverse migration and alleviates local inflammation

Journal of Leukocyte Biology
Abstract Polymorphonuclear neutrophil (PMN) infiltration at inflammatory site plays a critical role in inflammation. PMN reverse migration (rM) describes the phenomenon that PMNs migrate away from inflammatory site back into the vasculature, and its role within inflammatory scenarios remains to be fully determined.
Melanie Scott, Jie Fan, Timothy Billiar   +2 more
exaly   +4 more sources

Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1

Biochemical Pharmacology, 2023
Abdominal aortic aneurysm (AAA) is a common, usually asymptomatic disease with high mortality and limited therapeutic options. Extensive extracellular matrix (ECM) fragmentation and transmural inflammation act as major pathological processes of AAA. However, the underlying regulatory mechanisms remain incompletely understood.
Jianan, Huang, Yunlong, Jiang, Ruiyuan, Ji, Yutian, Jia, Saiya, Wang, Zhongqiu, Zhou, Siying, Wang, Jie, Wang, Qing, Yang, Hui, Bai, Xudong, Zhu, Bin, Jiang, Jingjing, Ben, Hanwen, Zhang, Xiaoyu, Li, Qi, Chen   +15 more
openaire   +2 more sources

Irg1 regulates bone homeostasis via regulating the Grk5 expression

Biochemical and Biophysical Research Communications
We have previously demonstrated that itaconic acid can regulate osteoclast differentiation in vitro and in vivo, thereby affecting the progression of osteoporosis. The role of Irg1 as itaconic acid catalytic enzyme in bone homeostasis has not been clearly elucidated.
Xuewu Sun, Boya Zhang, Putao Yuan, Huali Ye, Peihua Shi   +4 more
openaire   +2 more sources