Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus [PDF]
Applied Microbiology and Biotechnology, 2016 Itaconic acid, one of the most promising and flexible bio-based chemicals, is mainly produced by Aspergillus terreus. Previous studies to improve itaconic acid production in A. terreus through metabolic engineering were mainly focused on its biosynthesis pathway, while the itaconic acid-degrading pathway has largely been ignored. In this study, we used
Xuefeng Lu, Xuenian Huang, Lu Xuefeng
exaly +3 more sources
Development of an itaconic acid production process with Ustilaginaceae on alternative feedstocks [PDF]
BMC Biotechnology, 2023 Background Currently, Aspergillus terreus is used for the industrial production of itaconic acid. Although, alternative feedstock use in fermentations is crucial for cost-efficient and sustainable itaconic acid production, their utilisation with A ...
Paul-Joachim Niehoff +8 more
doaj +2 more sources
Bioconversion of mango peels into itaconic acid through submerged fermentation and statistical optimization of parameters through response surface methodology [PDF]
PeerJItaconic acid is an industrially crucial organic acid due to its broad range of applications. The main hurdle in itaconic acid production is the high cost of the substrate, i.e., pure glucose, required for the fermentation process.
Shagufta Saeed +5 more
doaj +3 more sources
Biochemistry of microbial itaconic acid production [PDF]
Frontiers in Microbiology, 2013 Itaconic acid is an unsatured dicarbonic acid which has a high potential as a biochemical building block, because it can be used as a monomer for the production of a plethora of products including resins, plastics, paints and synthetic fibers.
Matthias Georg Steiger +8 more
doaj +3 more sources
Itaconic Acid: A Regulator of Immune Responses and Inflammatory Metabolism [PDF]
Current Issues in Molecular BiologyThis article reviews the multifaceted roles of itaconate in immune regulation and inflammatory metabolism. Itaconic acid is a dicarboxylic acid with anti-inflammatory, antioxidant, and anti-tumor properties.
Kai Ma +5 more
doaj +2 more sources
Enhancing selective itaconic acid synthesis in Yarrowia lipolytica through targeted metabolite transport reprogramming [PDF]
Biotechnology for Biofuels and BioproductsBackground Itaconic acid is a valuable platform chemical with applications in polymer synthesis and other industrial sectors. Microbial fermentation offers a sustainable production route, involving two fungi such as Aspergillus terreus and Ustilago ...
Cosetta Ciliberti +8 more
doaj +2 more sources
Improved consolidated bioprocessing for itaconic acid production by simultaneous optimization of cellulase and metabolic pathway of Neurospora crassa [PDF]
Biotechnology for Biofuels and BioproductsLignocellulose was directly used in itaconic acid production by a model filamentous fungus Neurospora crassa. The promoters of two clock control genes and cellobiohydrolase 1 gene were selected for heterologous genes expression by evaluating different ...
Chen Zhao +4 more
doaj +2 more sources
4-Hydroxycinnamic acid and Itaconic acid exhibit broad spectrum synergy with conventional antibiotics in inhibiting multidrug-resistant Salmonella Typhimurium [PDF]
Scientific ReportsOne approach to combating the surge in bacterial antimicrobial resistance is to use adjuvants that sensitize drug-resistant strains to conventional antibiotics. Here, we evaluated 24 pure bioactive compounds for their antibiotic adjuvant activity against
Bismi Phasaludeen +11 more
doaj +2 more sources
Two cycles of chemotherapy modulate itaconic acid levels via ATF3/TET2/NF-κB pathways in ovarian cancer among Han Chinese women [PDF]
Journal of Ovarian ResearchBackground The metabolic rationale chemotherapy cycles after debulking surgery in ovarian cancer (OC) remain unclear. This prospective cohort was aimed to define metabolic changes induced by chemotherapy and assess longitudinal effects.
Ying Tang +11 more
doaj +2 more sources
Ameliorative Effect of Itaconic Acid/IRG1 Against Endoplasmic Reticulum Stress-Induced Necroptosis in Granulosa Cells via PERK-ATF4-AChE Pathway in Bovine [PDF]
CellsThe necroptosis of granulosa cells has been proven to be one of the important triggers of follicular atresia, which is an important cause of reduced reproductive capacity in cows.
Xiaorui Yang +13 more
doaj +2 more sources