Itaconic Acid Directly Binds to the Cysteine Residue of PurF: A Novel Mechanism for Inhibiting Purine Metabolism in Porcine Pathogenic Escherichia coli [PDF]
MicroorganismsItaconic acid has been reported to possess anti-inflammatory and antibacterial properties. However, its specific mechanisms of action against pathogenic bacteria, especially in the context of purine metabolism, remain poorly understood.
Haozhen Liu +6 more
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Development of an itaconic acid production process with Ustilaginaceae on alternative feedstocks [PDF]
BMC Biotechnology, 2023 Background Currently, Aspergillus terreus is used for the industrial production of itaconic acid. Although, alternative feedstock use in fermentations is crucial for cost-efficient and sustainable itaconic acid production, their utilisation with A ...
Paul-Joachim Niehoff +8 more
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Bioconversion of mango peels into itaconic acid through submerged fermentation and statistical optimization of parameters through response surface methodology [PDF]
PeerJItaconic acid is an industrially crucial organic acid due to its broad range of applications. The main hurdle in itaconic acid production is the high cost of the substrate, i.e., pure glucose, required for the fermentation process.
Shagufta Saeed +5 more
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Itaconic Acid: A Regulator of Immune Responses and Inflammatory Metabolism [PDF]
Current Issues in Molecular BiologyThis article reviews the multifaceted roles of itaconate in immune regulation and inflammatory metabolism. Itaconic acid is a dicarboxylic acid with anti-inflammatory, antioxidant, and anti-tumor properties.
Kai Ma +5 more
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Enhancing selective itaconic acid synthesis in Yarrowia lipolytica through targeted metabolite transport reprogramming [PDF]
Biotechnology for Biofuels and BioproductsBackground Itaconic acid is a valuable platform chemical with applications in polymer synthesis and other industrial sectors. Microbial fermentation offers a sustainable production route, involving two fungi such as Aspergillus terreus and Ustilago ...
Cosetta Ciliberti +8 more
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Integrated transcriptomic and metabolomic analysis reveals the regulatory role of itaconic acid in inflammatory infiltration during myocardial ischemia-reperfusion injury [PDF]
PeerJBackground Inflammatory infiltration constitutes a fundamental pathophysiological mechanism in myocardial ischemia-reperfusion (IR) injury, characterized by its role in initiating tissue damage, amplifying pathological inflammatory cascades, and ...
QuanWei Pei +6 more
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Improved consolidated bioprocessing for itaconic acid production by simultaneous optimization of cellulase and metabolic pathway of Neurospora crassa [PDF]
Biotechnology for Biofuels and BioproductsLignocellulose was directly used in itaconic acid production by a model filamentous fungus Neurospora crassa. The promoters of two clock control genes and cellobiohydrolase 1 gene were selected for heterologous genes expression by evaluating different ...
Chen Zhao +4 more
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4-Hydroxycinnamic acid and Itaconic acid exhibit broad spectrum synergy with conventional antibiotics in inhibiting multidrug-resistant Salmonella Typhimurium [PDF]
Scientific ReportsOne approach to combating the surge in bacterial antimicrobial resistance is to use adjuvants that sensitize drug-resistant strains to conventional antibiotics. Here, we evaluated 24 pure bioactive compounds for their antibiotic adjuvant activity against
Bismi Phasaludeen +11 more
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Two cycles of chemotherapy modulate itaconic acid levels via ATF3/TET2/NF-κB pathways in ovarian cancer among Han Chinese women [PDF]
Journal of Ovarian ResearchBackground The metabolic rationale chemotherapy cycles after debulking surgery in ovarian cancer (OC) remain unclear. This prospective cohort was aimed to define metabolic changes induced by chemotherapy and assess longitudinal effects.
Ying Tang +11 more
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Ameliorative Effect of Itaconic Acid/IRG1 Against Endoplasmic Reticulum Stress-Induced Necroptosis in Granulosa Cells via PERK-ATF4-AChE Pathway in Bovine [PDF]
CellsThe necroptosis of granulosa cells has been proven to be one of the important triggers of follicular atresia, which is an important cause of reduced reproductive capacity in cows.
Xiaorui Yang +13 more
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