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Immune-responsive gene 1 (IRG1) and dimethyl itaconate are involved in the mussel immune response
Fish & Shellfish Immunology, 2020Immune-responsive gene 1 (irg1) is a gene that is well-conserved among different taxa and is highly expressed in the mussel Mytilus galloprovincialis at the constitutive level. The expression of this gene increases after a bacterial infection, primarily in haemocytes.
Sendra, Marta +4 more
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Evaluating the role of IRG1 and itaconate on Marek's Disease virus infection
2022Marek’s Disease (MD) is an oncogenic pathology of chickens characterized by paralysis, immune suppression, and the induction of T-cell lymphomas. The causative agent of MD is the Alphaherpesvirus Marek’s Disease Virus (MDV), which is spread through the inhalation of infectious dander particles.
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IRG1/Itaconate Axis as an Immunometabolic Regulator of Pulmonary Hypertension
C107. AT THE CROSSROADS OF DISEASE: METABOLIC AND INFLAMMATORY DRIVERS IN PULMONARY VASCULAR DISEASE, 2023G. Hesami +7 more
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Expression of IRG1 in Microglia and its Effects on Hif1α and IRF7
Upon exposure to LPS and IFNγ, IRG1 (immune-responsive gene 1) expression highly increases in macrophages and microglia. It regulates immunometabolism in the cell and so is involved in metabolic and inflammatory changes cells go through under inflammatory conditions. Some of the major transcription factors that regulate cell metabolism and inflammatoryRubavičiūtė, Estera +1 more
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The IRG1-Itaconate axis: A regulatory hub for immunity and metabolism in macrophages
International Reviews of Immunology, 2023Yun Zhao, Wenbin Gong, Xiuwen Wu
exaly
2015
The immune system is the first line of defence against invading pathogens. Macrophages are the key effector cells of the innate immune system which produce an array of cytokines, antimicrobial peptides, and effector molecules pathogen in response to pathogen invasion.
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The immune system is the first line of defence against invading pathogens. Macrophages are the key effector cells of the innate immune system which produce an array of cytokines, antimicrobial peptides, and effector molecules pathogen in response to pathogen invasion.
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AB0128 IMMUNE RESPONSE GENE 1 (IRG1) IS DYSREGULATED IN SYSTEMIC SCLEROSIS
Annals of the Rheumatic Diseases, 2022openaire +1 more source