Results 111 to 120 of about 2,411 (155)

Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity. [PDF]

Blood Red Cells Iron
Ruan B, Chen Y, Trimidal S, Chakraborty M, Shah A, Gong H, Koo I, Cai J, Mcguigan J, Hall MA, Patterson AD, Prabhu KS, Paulson RF.   +12 more
europepmc   +1 more source

IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition

Cell Metabolism
Siavash Mansouri, Golnaz Hesami, Anoop Ambikan, Annika Karger, Stephan Klatt, Ujjwal Neogi, Konda Babu Kurakula, Blerina Aliraj, Anne Miller, Boryana Petrova, Miloslav Sanda, Evelyn Sirait-Fischer, Stefan Guenther, Carsten Kuenne, Clemens Ruppert, Ibrahim Alkoudmani, Stefan Gattenlöhner, Sven Zukunft, Ingrid Fleming, Arvand Haschemi, Thorsten Stiewe, Friedrich Grimminger, Martin Reck, Andreas Weigert, Werner Seeger, Soni Savai Pullamsetti, Rajkumar Savai   +26 more
openaire   +1 more source

Ameliorative Effect of Itaconic Acid/IRG1 Against Endoplasmic Reticulum Stress-Induced Necroptosis in Granulosa Cells via PERK-ATF4-AChE Pathway in Bovine. [PDF]

Cells
Yang X, Chen Y, Wang X, Xu G, Wang H, Shu X, Ding H, Ma X, Guo J, Wang J, Zhao J, Fang Y, Liu H, Lu W.   +13 more
europepmc   +1 more source

Metabolic gatekeeping in murine stress erythropoiesis. [PDF]

Blood Red Cells Iron
Serra M, Blanc L.
europepmc   +1 more source

High glucose induces pro-inflammatory polarization of macrophages by inhibiting immune-responsive gene 1 expression. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Luo W, Wang Y, Liu Y, Wang Y, Ai L.
europepmc   +1 more source

Effect of antibiotics on Kupffer cell immunometabolism relative to intracellular killing of <i>S. aureus</i> using NAD(P)H fluorescence lifetime imaging. [PDF]

mBio
Beadell B, Wong-Beringer A.
europepmc   +1 more source

IRF2 Affects LPS- and IFN-γ-Induced Pro-Inflammatory Responses, Cell Viability, Migration and Apoptosis of Macrophages by Regulating IRG1. [PDF]

J Inflamm Res
Qin RX, Ma XY, Han ZY, Ma SY, Shen ZJ, Lu ZH, Sun Y, Yu WL.   +7 more
europepmc   +1 more source

CNS Synthesis Report 2016: IRG1: Exploring Nanotechnology's Origins, Institutions, and Communities

, 2016
Mody, Cyrus C.M., McCray, W. Patrick, Slaton, Amy, Tyrrell, Brian   +3 more
openaire   +1 more source

Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation [PDF]

Cell Reports, 2022
The metabolism of activated macrophages relies on aerobic glycolysis, while mitochondrial oxidation is disrupted. In lipopolysaccharide-activated macrophages, the citrate carrier (CIC) exports citrate from mitochondria to enhance glycolytic genes through histone acetylation. CIC inhibition or Slc25a1 knockdown reduces the occupancy of H3K9ac to hypoxia-
Lu Zhang, Ping Li
exaly   +3 more sources

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The IRG1-Itaconate axis: A regulatory hub for immunity and metabolism in macrophages

International Reviews of Immunology, 2022
Metabolism could be served as a guiding force for immunity, and macrophages undergo drastic metabolic reprogramming during inflammatory processes, including enhancing glycolysis and reshaping the tricarboxylic acid cycle (TCA) cycle. The disrupted TCA cycle facilitates itaconate accumulation, consistent with the significant up-regulation of immune ...
Yangguang Li, Wenbin Gong, Weizhen Li, Peizhao Liu, Juanhan Liu, Haiyang Jiang, Tao Zheng, Jie Wu, Xiuwen Wu, Yun Zhao, Jianan Ren   +10 more
openaire   +2 more sources