Results 111 to 120 of about 2,835 (186)

Transcriptome analysis of Interferon gamma and Tumor necrosis factor regulated Genes in murine macrophages: cloning and characterization of IRG1 and mGBP6

, 2009
Das Hauptaugenmerk dieser Arbeit galt IFNgamma und TNF regulierte Gene zu identifizieren, die eine Rolle bei der Immunabwehr gegen intrazelluläre Mikroben spielen.
Degrandi, Daniel
core  

Transkriptomanalyse von Interferon γ und Tumor-Nekrose-Faktor-regulierten Genen in murinen Makrophagen Klonierung und Charakterisierung von IRG1 und mGBP6.

, 2007
Das Hauptaugenmerk dieser Arbeit galt IFNgamma und TNF regulierte Gene zu identifizieren, die eine Rolle bei der Immunabwehr gegen intrazelluläre Mikroben spielen.
Degrandi, D.
core  

Metabolic Profiling Reveals a Glycolytic Shift and an IRG1/Itaconate/NF2L2 Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia

Polar metabolic profiling, as well as bioenergetic assays, were used to characterize microglial responses to lipopolysaccharide, which induces a pro-inflammatory state, and interleukin-4, which is associated with an anti-inflammatory phenotype.
Engskog-Vlachos, Pinelopi, Grabert, Kathleen, Osman, Ahmed M., Blomgren, Klas, Berggren, Per-Olof, Sylaidi, Theodora, Engskog, Mikael K R, St-Pierre, Marie-Kim, Joseph, Bertrand, Skandik, Martin, Moruzzi, Noah   +10 more
core   +1 more source

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8. [PDF]

Exp Mol Med
Qian J, Tan Z, Wang J, Wei T, Huang C, Cheng S, Zhong G, Zou H, Kang X, Sun L, Zhang Y.   +10 more
europepmc   +1 more source

Targeting IRG1 in tumor-associated macrophages for cancer therapy

Protein & Cell
Shuang Liu, Lin-Xing Wei, Qian Yu, Zhi-Wei Guo, Chang-You Zhan, Lei-Lei Chen, Yan Li, Dan Ye   +7 more
openaire   +2 more sources

Intercellular transfer of LncRNA <i>NEAT1</i> drives post-infarction inflammation by blocking the macrophage IRG1-itaconate metabolic axis. [PDF]

Biochem Biophys Rep
Ge J, Ge D.
europepmc   +1 more source

ImPaqT, a Golden Gate-based immunological toolkit for zebrafish transgenesis. [PDF]

Elife
Hurst S, Dimmler C, Cronan MR.
europepmc   +1 more source

Revisiting macrophage metabolic reprogramming in metabolic dysfunction-associated steatotic liver disease: mechanisms, regulation, and therapeutic breakthroughs. [PDF]

Front Immunol
Zhu L, Wu B.
europepmc   +1 more source

Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis. [PDF]

Nat Metab
Tang J, Pernes G, Nakagaki B, Tran N, Bokor L, Prenen F, Yi M, Robertson AE, Cronin R, Sarmini M, Pierscianowski J, Roberts V, Ryback BA, Novina CD, Auclair K, Xiao H, Mills EL.   +16 more
europepmc   +1 more source

Itaconic Acid Directly Binds to the Cysteine Residue of PurF: A Novel Mechanism for Inhibiting Purine Metabolism in Porcine Pathogenic <i>Escherichia coli</i>. [PDF]

Microorganisms
Liu H, Li X, Zhang X, Ge Y, Chen Y, Li X, Wu Z.   +6 more
europepmc   +1 more source