Results 81 to 90 of about 2,835 (186)

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, Volume 59, Issue 4, April 2026.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

The crystal structure of mouse IRG1 suggests that cis-aconitate decarboxylase has an open and closed conformation

PLOS ONE, 2020
Itaconate, produced as an offshoot of the TCA cycle, is a multifunctional immunometabolite possessing antibacterial, antiviral, immune regulation, and tumor progression activities. The production of itaconate in biological systems is catalyzed by cis-aconitate decarboxylase (CAD, also known as immune responsive gene 1 (IRG1) in mammals). In this study,
Hye Lin Chun, So Yeon Lee, Ki-Hwa Kim, Chang Sup Lee, Tae-Jin Oh, Hyun Ho Park   +5 more
openaire   +4 more sources

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

Nanomedicine Targeting Macrophage Immunometabolism in Atherosclerosis: Mechanisms and Therapeutic Prospects

Organ Medicine, Volume 3, Issue 1, Page 27-53, March 2026.
ABSTRACT Atherosclerosis, a chronic inflammatory–metabolic disorder, remains a leading cause of cardiovascular morbidity worldwide. This review explores the emerging paradigm of nanomedicine‐based targeting of macrophage immunometabolic reprogramming as a potentially transformative strategy for atherosclerosis treatment.
Zhenyu Liu, Wenfan Yang, Na Wang, Ya Wu
wiley   +1 more source

IRF2 Affects LPS- and IFN-γ-Induced Pro-Inflammatory Responses, Cell Viability, Migration and Apoptosis of Macrophages by Regulating IRG1

Journal of Inflammation Research
Ru-Xue Qin, Xue-Ying Ma, Zi-Yu Han, Shi-Ya Ma, Zhao-jian Shen, Zhong-Hua Lu, Yun Sun,* Wei-Li Yu* The First Department of Critical Care Medicine, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, People’s Republic of ...
Qin RX, Ma XY, Han ZY, Ma SY, Shen ZJ, Lu ZH, Sun Y, Yu WL   +7 more
doaj  

Cancer cell-intrinsic biosynthesis of itaconate promotes tumor immunogenicity

The EMBO Journal
The Krebs cycle byproduct itaconate has recently emerged as an important metabolite regulating macrophage immune functions, but its role in tumor cells remains unknown.
Zining Wang, Lei Cui, Yanxun Lin, Bitao Huo, Hongxia Zhang, Chunyuan Xie, Huanling Zhang, Yongxiang Liu, Huan Jin, Hui Guo, Mengyun Li, Xiaojuan Wang, Penghui Zhou, Peng Huang, Jinyun Liu, Xiaojun Xia   +15 more
doaj   +1 more source

Genetic and functional characterisation of irg1 and irg1-like, two genes which are highly expressed during bacterial infection in zebrafish (Danio rerio)

, 2011
Full text is available to authenticated members of The University of Auckland only.We aimed to identify two novel immune responsive genes in zebrafish (Danio rerio) and subsequently characterise their expression patterns during the innate immune response
Boyle, Rachel
core  

Cell-Intrinsic Role of Immune-Responsive Gene 1 (Irg1) in CD4+ T Cells: Implications for CNS Autoimmunity 2259561

Introduction CD4+ Th17 cells are central drivers of multiple sclerosis (MS) pathology, yet mechanisms regulating their differentiation and effector functions is not fully understood.
Mohammad Nematullah, Shailendra Giri, Mena Fatma, Ramandeep Rattan   +3 more
core   +1 more source

wurunliu/IRG1-CDK2-JUN-NGS-analysis: ACOD1-CDK2-JUN-NGS-analysis

, 2022
No description ...
wurunliu
core   +1 more source

Investigating the contribution of Immunoresponsive gene 1 (Irg1) to macrophage functions and its relevance to disease

, 2015
Macrophages are essential effectors in the innate immune responses to injury, infection, and disease. Their broad functional plasticity allows them to tailor their behaviours to the specific homeostatic or immune needs of their microenvironment. However,
Sanderson, Leslie
core