Results 81 to 90 of about 2,411 (155)

Transcripts of COL4A2, IRG1, MMP12 genes as potential biomarkers of bull sperm quality

Agrarian science
Relevance. The aim of this work is to validate three sperm transcripts of candidate genes COL4A2, IRG1, MMP12 obtained using RNA-Seq and correlation analysis of their expression levels with high and low sperm quality indicators of Holstein bulls.Methods. Eighteen samples of cryopreserved sperm ejaculate were studied.
O. Yu. Barkova, D. A. Starikova, I. V. Chistyakova, N. V. Pleshanov, A. V. Gabova   +4 more
openaire   +1 more source

Transcriptome analysis on pulmonary inflammation between periodontitis and COPD

Heliyon
Objective: The aim of this study is to investigate the correlation between periodontal disease and chronic obstructive pulmonary disease (COPD) from the perspective of gene regulation, as well as the inflammatory pathways involved. Methods: Forty C57BL/6
Kaili Wang, Xiaoli Gao, Hongjia Yang, Huan Tian, Zheng Zhang, Zuomin Wang   +5 more
doaj   +1 more source

IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection

, 2019
Abstract Mycobacterium tuberculosis ( Mtb ), the pathogen causing human tuberculosis, has evolved multiple strategies to successfully prevent clearance by immune cells and to establish dissemination and long-term survival in the host. The modulation of host immunity to maximize pathogen elimination while minimizing inflammation-mediated tissue ...
Hoffmann, Eik, Machelart, Arnaud, Belhaouane, Imène, Deboosere, Nathalie, Pauwels, Anne-Marie, Saint-André, Jean-Paul, Song, Ok-Ryul, Jouny, Samuel, Poncet, Anaïs, Marion, Sabrina, Beyaert, Rudi, Majlessi, Laleh, Brodin, Priscille   +12 more
openaire   +1 more source

Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2

Cell Communication and Signaling
Nasopharyngeal carcinoma (NPC) is a malignant tumor of epithelial origin in head and neck with high incidence rate in South China, Southeast Asia and North Africa.
Xiaowei Zhang, Shen’er Qian, Ping’an Wu, Benquan Yu, Danhui Yin, Xia Peng, Shisheng Li, Zian Xiao, Zuozhong Xie   +8 more
doaj   +1 more source

Dual proteomics of infected macrophages reveal bacterial and host players involved in the Francisella intracellular life cycle and cell to cell dissemination by merocytophagy

Scientific Reports
Bacterial pathogens adapt and replicate within host cells, while host cells develop mechanisms to eliminate them. Using a dual proteomic approach, we characterized the intra-macrophage proteome of the facultative intracellular pathogen, Francisella ...
Héloïse Rytter, Kevin Roger, Cerina Chhuon, Xiongqi Ding, Mathieu Coureuil, Anne Jamet, Thomas Henry, Ida Chiara Guerrera, Alain Charbit   +8 more
doaj   +1 more source

iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria. [PDF]

Nat Metab
Diotallevi M, Outeiral C, Patel P, Purvis GSD, Chuaiphichai S, Nicol T, Ayaz F, Nissley DA, Krasnoselska GO, Hester S, McVey JH, Fischer R, Kessler B, Deane CM, Owens RJ, Channon KM, Crabtree MJ.   +16 more
europepmc   +1 more source

Human pneumovirus induces IFN-dependent expression of the immune-responsive gene 1 and is inhibited by 4-octyl itaconate in human macrophages. [PDF]

NAR Mol Med
Spahn AS, Rian K, Gidon A, Louet C, Boyartchuk V, Flo TH, Anthonsen MW.   +6 more
europepmc   +1 more source

Role of itaconate in intestinal disease (Review). [PDF]

Int J Mol Med
Li X, Liu Q, Li J, Zhang L, Yao S, Tang L, Yang B, Wang Y, Wen G, An J, Jin H, Tuo B.   +11 more
europepmc   +1 more source

Metabolite-neuro-immune relay in chronic pain: spatial-temporal lactate, succinate and itaconate signalling as drivers of glial reprogramming and neuronal sensitisation. [PDF]

Front Pharmacol
Hu Z, Ji Q, Xiong Q, Ning Y, Rao Y, Fu J, Wang L, Xiong X, Ou C, Zhang Y.   +9 more
europepmc   +1 more source

STAT1 itaconation prevents macrophage cytolistic mtDNA -induced inflammation in wear particle-induced aseptic loosening. [PDF]

Cell Commun Signal
Yu Y, Liu T, Pan C, Sun H, Chen Z, Liu H, Ko W, Tan S, Luo J, Li S, Li C, Ding Y.   +11 more
europepmc   +1 more source