Results 51 to 60 of about 2,411 (155)

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Connexin Regulation and Modulation of Neural Stem Cell Differentiation Induced by Cell‐Permeable Itaconate

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
The immunometabolite itaconate modulates the connexin profile of neural stem cells, and it upregulates Cx36‐based channels, promoting the differentiation toward a neuronal phenotype. These effects were abolished by connexin blockade, supporting a role for itaconate in the neuroimmune axis in inflammatory and neurodegenerative disorders. ABSTRACT Neural
Simona Denaro, Simona Rosa Spina, Simona D'Aprile, Anna Gervasi, Filippo Torrisi, Carmela Parenti, Agata Zappalà, Nunzio Vicario, Rosalba Parenti   +8 more
wiley   +1 more source

Deficiency of IRG1/ itaconate aggravates endotoxemia-induced acute lung injury by inhibiting autophagy in mice

Experimental Animals, 2023
Itaconate, produced by aconitate decarboxylase 1 (ACOD1), which is encoded by immune-responsive gene 1 (Irg1), is one of the metabolites derived from the tricarboxylic acid cycle. It has been reported that exogenous itaconate plays an anti-inflammatory role in the progression of multiple diseases and pathological processes, including activated ...
Qiu, Jing-Huan, Zhang, Li, Li, Ke-Xin, Zhang, Qiu-Hong, Fan, Ke-Rui, Chen, Kun, Jiang, Yu, Liu, Gang   +7 more
openaire   +2 more sources

/itaconate activates Nrf2/HO-1 pathway and mitigates septic liver injury in mice

European Journal of Inflammation
Objectives: Immune-responsive gene 1 ( Irg1 )-catalyzed production of itaconate is a bioactive metabolite with antibacterial, anti-inflammatory and antioxidant properties.
Tingting Zhang, Kexin Li, Jinghuan Qiu, Li Zhang, Xiaoliang Wang, Qiuhong Zhang, Yin Qin, Jie Liu, Gang Liu   +8 more
doaj   +1 more source

Senescent Factors Suppress Innate Antiviral Immunity in Aged Mice via Two Distinct Mechanisms

Aging Cell, Volume 25, Issue 4, April 2026.
Four secreted factors from senescent cells, including GDF15, IGF1, IL1α, and IL6, cooperatively suppress antiviral innate immunity. GDF15/IGF1 trigger AKT‐MEK‐mediated inactivation of GSK3β, leading to suppression of the TBK1‐IRF3 axis, whereas IL1α/IL6 induce p52 and RelB to suppress transcription of antiviral genes.
Xu Zhang, Qi Zhang, Li Wang, Shu Li, Hong‐Bing Shu   +4 more
wiley   +1 more source

Heterologous expression of Mus musculus immunoresponsive gene 1 (irg1) in Escherichia coli results in itaconate production

Frontiers in Microbiology, 2015
Itaconic acid, a C5-dicarboxylic acid, is a potential biobased building block for the polymer industry. It is obtained from the citric acid cycle by decarboxylation of cis-aconitic acid.
Kiira S Vuoristo, Astrid E Mars, Stijn van eLoon, Enrico eOrsi, Gerrit eEggink, Johan P.M. Sanders, Ruud A Weusthuis   +6 more
doaj   +1 more source

Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2

EBioMedicine, 2020
Absract: Background: Identifying effective drugs to suppress vascular inflammation is a promising strategy to delay the progression of abdominal aortic aneurysm (AAA).
Haoyu Song, Tong Xu, Xiaofei Feng, Yanxian Lai, Yang Yang, Hao Zheng, Xiang He, Guoquan Wei, Wangjun Liao, Yulin Liao, Lintao Zhong, Jianping Bin   +11 more
doaj   +1 more source

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, Volume 59, Issue 4, April 2026.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia.

PLoS Pathogens
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in which neutrophils play a critical role. Immune-responsive gene 1 (IRG1), responsible for itaconate production, has emerged as an important regulator of inflammation and infection,
Cui Wang, Jun Wen, Zijun Yan, Yujun Zhou, Zhande Gong, Ying Luo, Zhenkui Li, Kang Zheng, Haijun Zhang, Nan Ding, Chuan Wang, Cuiming Zhu, Yimou Wu, Aihua Lei   +13 more
doaj   +1 more source