Results 51 to 60 of about 2,835 (186)
Journal of Inflammation Research, 2022 Atomu Yamaguchi,1 Noriaki Maeshige,1 Xiaoqi Ma,1 Mikiko Uemura,1 Hikari Noguchi,1 Mami Matsuda,2 Yuya Nishimura,2 Tomohisa Hasunuma,2,3 Hiroyo Kondo,4 Hidemi Fujino1 1Department of Rehabilitation Science, Kobe University Graduate School of Health ...
Yamaguchi A +9 more
doaj
Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States
Glia, Volume 74, Issue 10, October 2026.Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar +3 more
wiley +1 more source
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection
, 2021 Immune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions, principally in cells of myeloid lineage. Cell culture studies suggest that itaconate regulates inflammation through its inhibitory effects on
Nair S.
core
4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING
Cell Reports, 2023 Summary: The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins.
Weizhen Li +10 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang +4 more
wiley +1 more source
IRG1 is regulated by IFNs and restricts L. pneumophila within their vacuoles.
, 2016 (A-D) BMMs (A, B) or alveolar macrophages (C, D) were transfected with control or two IRG1 siRNAs separately (A, B) or pooled (C, D), infected with L. pneumophila, Irg1 expression was assessed 24 h p.i. (A, C), and CFUs were counted 72 h p.i. (B, D). (E,
Achim D. Gruber (141051) +22 more
core +1 more source
Hepatic IRG1 promotes apoptosis and hepatocarcinogenesis by trapping Mcl-1
, 2022 Raw data for "Hepatic IRG1 promotes apoptosis and hepatocarcinogenesis by trapping Mcl-1"THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Zhang, L (via Mendeley Data)
core +1 more source
Tissue‐Resident Macrophage in Inflammation and Cancer
MedComm, Volume 7, Issue 9, September 2026.Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang +13 more
wiley +1 more source
Hepatic IRG1 promotes carcinogenesis by trapping Mcl-1 to induce liver injury
, 2022 Original data for Hepatic IRG1 promotes carcinogenesis by trapping Mcl-1 to induce liver injury.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Zhang, L (via Mendeley Data)
core +1 more source
Experimental Animals, 2023 Itaconate, produced by aconitate decarboxylase 1 (ACOD1), which is encoded by immune-responsive gene 1 (Irg1), is one of the metabolites derived from the tricarboxylic acid cycle. It has been reported that exogenous itaconate plays an anti-inflammatory role in the progression of multiple diseases and pathological processes, including activated ...
Qiu, Jing-Huan +7 more
openaire +2 more sources