Results 31 to 40 of about 2,411 (155)

Skeletal myotube-derived extracellular vesicles enhance itaconate production and attenuate inflammatory responses of macrophages

Frontiers in Immunology, 2023
IntroductionMacrophages play an important role in the innate immunity. While macrophage inflammation is necessary for biological defense, it must be appropriately controlled.
Atomu Yamaguchi, Noriaki Maeshige, Jiawei Yan, Xiaoqi Ma, Mikiko Uemura, Mami Matsuda, Yuya Nishimura, Tomohisa Hasunuma, Tomohisa Hasunuma, Hiroyo Kondo, Hidemi Fujino, Zhi-Min Yuan   +11 more
doaj   +1 more source

Metabolite itaconate in host immunoregulation and defense

Cellular & Molecular Biology Letters, 2023
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune cells can effectively modulate the host immune response.
Wenchang Yang, Yaxin Wang, Kaixiong Tao, Ruidong Li   +3 more
doaj   +1 more source

OLFML3 Promotes IRG1 Mitochondrial Localization and Modulates Mitochondrial Function in Macrophages. [PDF]

Int J Biol Sci
Olfactomedin-like protein 3 (OLFML3), belonging to olfactomedin (OLF) protein family, has poorly defined functions. Recent studies have reported the functions of OLFML3 in anti-viral immunity and tumorigenesis. In this study, we investigated the roles of OLFML3 in macrophages.
Yu Q, Mei H, Gu Q, Zeng R, Li Y, Zhang J, Gao C, Fang H, Qu J, Liu J.   +9 more
europepmc   +3 more sources

Metabolic Profiling Reveals a Glycolytic Shift and an IRG1 /Itaconate/ NF2L2 Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia [PDF]

Journal of Neurochemistry
Bertrand Joseph
exaly   +2 more sources

Enzymatic reaction mechanism of cis-aconitate decarboxylase based on the crystal structure of IRG1 from Bacillus subtilis

Scientific Reports, 2020
Itaconate, which is formed by decarboxylation of cis-aconitate—an intermediate metabolite in the tricarboxylic acid cycle—has been used as a building block in polymer synthesis and is an important chemical in several biomedical and industrial ...
Hye Lin Chun, So Yeon Lee, Sung Hoon Lee, Chang Sup Lee, Hyun Ho Park   +4 more
doaj   +1 more source

Immunoresponsive Gene 1–Itaconate Exacerbates Hypertension by Inhibiting the Cystathionine Gamma-Lyase/Hydrogen Sulfide Pathway

Journal of Cardiovascular Development and Disease
The role of immunoresponsive gene 1 (IRG1)–itaconate (ITA) in hypertension remains poorly understood. This study aimed to investigate this role and the underlying mechanisms.
Minglu Ma, Chenyu Fan, Shuping Han, Hu Wang, Yuzhou Xue, Boyang Lv, He Huang, Hongfang Jin, Ling Jin, Jian Liu   +9 more
doaj   +1 more source

Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS

Scientific Reports, 2021
Itaconic acid is produced by immune responsive gene 1 (IRG1)-coded enzyme in activated macrophages and known to play an important role in metabolism and immunity.
Xiaoyang Zhu, Yangyang Guo, Zhigang Liu, Jingyi Yang, Huiru Tang, Yulan Wang   +5 more
doaj   +1 more source

Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst

Cell Reports, 2023
Summary: Neutrophils are critical in the host defense against Staphylococcus aureus, a major human pathogen. However, even in the setting of a robust neutrophil response, S. aureus can evade immune clearance. Here, we demonstrate that S.
Kira L. Tomlinson, Sebastián A. Riquelme, Swikrity Upadhyay Baskota, Marija Drikic, Ian R. Monk, Timothy P. Stinear, Ian A. Lewis, Alice S. Prince   +7 more
doaj   +1 more source

Itaconic acid, a missing link in macrophage activation, is produced by IRG1

The FASEB Journal, 2013
Itaconic acid (ITA) is a metabolite produced by primary macrophages and cell lines derived from macrophages that is dramatically increased upon activation. ITA is synthesized by a cis‐aconitate decarboxylase (cADC). Sequence searches with a known fungal cADC show little homology to ORFs in mammalian cells.
Jiongjia Cheng, Delilah Jewel, Thomas C. Chiles, Boguslaw Stec, Mary Fedarko Roberts   +4 more
openaire   +1 more source

The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity

iScience, 2022
ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in response to toll-like receptor (TLR) signaling.
Feng Chen, Runliu Wu, Jiao Liu, Rui Kang, Jinbao Li, Daolin Tang   +5 more
openaire   +3 more sources