Results 51 to 60 of about 6,203 (152)

The potential of using itaconate as treatment for inflammation-related heart diseases

Tzu Chi Medical Journal, 2022
Intracellular metabolites can cause critical changes in biological functions. Itaconate is perhaps the most fascinating substance in macrophages. Lipopolysaccharide can activate aconitate decarboxylase 1 and induces the generation of itaconate from the ...
Hui-Chen Ku, Ta-Chung Shen, Ching-Feng Cheng   +2 more
doaj   +1 more source

A Multidimensional Framework for Interpreting Macrophage Markers in the Era of Cellular Heterogeneity

Immunology, EarlyView.
Macrophage markers should be interpreted as context‐dependent biological readouts rather than deterministic cell identifiers. This Review proposes a multidimensional framework integrating lineage, identity, and functional state across complementary experimental modalities to enable a more accurate interpretation of macrophage heterogeneity.
Alessandro Palma
wiley   +1 more source

Poly(dialkoxyethyl itaconate)s—I.

, 1995
The preparation of dimethoxyethyl itaconate and its polymerisation are described. Some of the properties of the monomer and polymer were determined with special emphasis on the experimental determination of the solubility parameter of the polymer, δp ...
J.M. Filipović, K. Diesner, Veličković, Jovan S., I.G. Popović, J.S. Veličković, D.M. Petrović-Djakov, Petrović-Đakov, Dušanka, Filipović, Jovanka M., L. Katsikas, Diesner, K., Stanojević, N.G., Katsikas, Lynne, Popović, Ivanka, N.G. Stanojević   +13 more
core   +1 more source

Pharmacological Modulation of Nrf2 Signaling Regulates Oxidative Stress, Inflammation, and Alveolar Bone Loss in Experimental Periodontitis

Journal of Periodontal Research, EarlyView.
Pharmacological activation of Nrf2 attenuated alveolar bone loss and protected periodontal tissues by reducing inflammation and oxidative stress, preserving collagen organization, and favoring bone homeostasis. Reversal of these effects by Nrf2 inhibition further supports Nrf2 signaling as a promising therapeutic target in periodontitis.
Vitória Bonan Costa, Mariely Araújo de Godoi, Angelo Constantino Camilli, Isabela Rinaldi Gomes Nogueira, Veronica Canela Estevam dos Santos, Lucas Nogueira Ramos, Juliana Silva Siqueira, Camila Renata Corrêa Camacho, Morgana Rodrigues Guimarães Stabili   +8 more
wiley   +1 more source

ABA type block copolymers of poly(monobutyl itaconate) and poly(monocyclohexyl itaconate) with poly(dimethylsiloxane): Synthesis and characterization

, 2000
Monoesters of itaconic acid (monobutyl itaconate and monocyclohexyl itaconate) were synthesized and used as monomers. Poly(monobutyl itaconate) (PMBI) and poly(monocyclohexyl itaconate) (PMCHI) were prepared by free radical polymerization of these ...
Buzarovska, A, Baysal, BM, Cvetkovska, M, Popović, Ivanka, Katsikas, Lynne, Koseva, S, Yasar, B, Karal-Yilmaz, O   +7 more
core   +2 more sources

Transcriptome Analysis Reveals Distinct Molecular Signatures Between Erosive and Non‐Erosive Oral Lichen Planus

Oral Diseases, EarlyView.
ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen, Chaerim Song, Kanghyun Kwon, Seoyeon Kim, Hye‐Ji Park, Man S. Kim   +5 more
wiley   +1 more source

The cell autonomous and non-autonomous roles of itaconate in immune response

Cell Insight
Itaconate which is discovered as a mammalian metabolite possessing antimicrobial and immunoregulatory activity has attracted much attention in the field of immunometabolism. Itaconate is synthesized by myeloid cells under conditions of pathogen infection
Chao Chen, Xinjian Li
doaj   +1 more source

Promoters from the itaconate cluster of Ustilago maydis are induced by nitrogen depletion

Fungal Biology and Biotechnology, 2017
Background Ustilago maydis is known for its natural potential to produce a broad range of valuable chemicals, such as itaconate, from both industrial carbon waste streams and renewable biomass.
Thiemo Zambanini, Sandra K. Hartmann, Lisa M. Schmitz, Linda Büttner, Hamed Hosseinpour Tehrani, Elena Geiser, Melanie Beudels, Dominik Venc, Georg Wandrey, Jochen Büchs, Markus Schwarzländer, Lars M. Blank, Nick Wierckx   +12 more
doaj   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Protective Role for Itaconate During Inhaled Allergen Challenge [PDF]

Background: Asthma is a chronic, heterogeneous disease characterised by airway remodelling, inflammation, and mucus production. Airway macrophages' functions are underpinned by changes in cellular metabolism.
Gauvreau, Gail M., O'Byrne, Paul M., Michalaki, Christina, O'Brien, Helen, Halket, John M., Caldwell, Anna, Duvall, Kathryn, Albers, Gesa J., Lloyd, Clare M., Stölting, Helen, Byrne, Adam J., Ogger, Patricia P., Walker, Simone A., McCarthy, Cormac, Batool, Atia, Hinks, Timothy, Joshi, Lisha   +16 more
core   +1 more source