Results 71 to 80 of about 6,203 (152)

Liver Metastases from Colorectal Cancer: From Pathogenesis to Current Treatment

MedComm, Volume 7, Issue 10, October 2026.
The liver is not merely a passive recipient of disseminated tumor cells, but a unique metastatic organ shaped by anatomical, metabolic, and immunological characteristics that support tumor colonization. Increasing evidence indicates that colorectal cancer liver metastasis development is driven by dynamic interactions between tumor intrinsic programs ...
Jialiang Fan, Huiru Zhang, Deyang Kong, Yu Sun, Shuaibing Lu, Wenjing Yang, Renshen Xiang, Qi Zhang, Wei Pei, Haizeng Zhang, Lin Feng   +10 more
wiley   +1 more source

Selective Photoinduced α‐Amino C(sp3)–H Alkylation Mediated by NHC–Borane

Advanced Synthesis &Catalysis, Volume 368, Issue 17, 1 September 2026.
Herein, we report a selective photoinduced functionalization of α‐amino C(sp3)─H bonds mediated by NHC–boranes. This reaction proceeds efficiently without the need for any external radical initiator or photoredox catalyst. Mechanistic studies reveal that the reaction proceeds via an efficient radical chain, featuring the formation of an aryl radical ...
Gabin Lalande, Laurent Chabaud, Mathieu Pucheault   +2 more
wiley   +1 more source

Metabolic engineering of itaconate production in Escherichia coli

, 2015
Interest in sustainable development has led to efforts to replace petrochemical-based monomers with biomass-based ones. Itaconic acid, a C5-dicarboxylic acid, is a potential monomer for the chemical industry with many prospective applications.
Sanders, J.P.M., Sanders, Johan P.M., Eggink, Gerrit, Springer, Jan, Vuoristo, Kiira S.; id_orcid, Vuoristo, K.S., Sangra, Jose Vidal, Mars, A.E., Eggink, G., Vidal Sangra, J., Springer, J., Mars, Astrid E., Weusthuis, R.A., Weusthuis, Ruud A.   +13 more
core   +1 more source

Table_1_Aging Relevant Metabolite Itaconate Inhibits Inflammatory Bone Loss.xlsx

, 2022
Progressive bone loss during aging makes osteoporosis one of the most common and life impacting conditions in geriatric populations. The bone homeostasis is maintained through persistent remodeling mediated by bone-forming osteoblast and bone-resorbing ...
Jun Xiao (179459), Wentao Zhu (477548), Liming Zhao (2329306), Jian Liu (33711), Anmin Chen (13134768), Peng Cheng (153428), Song Li (65582), Fengjing Guo (6408467), Yuting Wang (434390)   +8 more
core   +1 more source

Itaconate modifications: Mechanisms and applications

Journal of Intensive Medicine
Itaconate is a mitochondrial metabolite generated from the tricarboxylic acid cycle intermediate cis-aconitate by the enzyme aconitate decarboxylase 1 (ACOD1).
Yingyi Yang, Rui Kang, Huiting Zhou, Daolin Tang   +3 more
doaj   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Itaconate and its derivatives as anti-pathogenic agents / [PDF]

Pathogenic microorganisms and viruses cause outbreaks and pandemics that affect millions of people worldwide. Despite recent advances in pharmacology and medicine, the ability of infectious diseases to spread in the modern era is accelerating due to ...
Maliene, Vida,, Malys, Naglis,, Al Akiki Dit Al Mazraani, Rizkallah,   +2 more
core   +2 more sources

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 [PDF]

, 2018
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood1,2,3.
Kessler, Benedikt, Hams, Emily, King, Martin S., Zaslona, Z, Hams, E, Kessler, BM, Carroll, Richard G., Louise K. Modis, O'Neill, Luke A., Anne F. McGettrick, Roman Fischer, Ashford, MLJ, Stuart T. Caldwell, Dinkova-Kostova, Albena T., Prag, HA, Menon, Deepthi, DG, Ryan, Frezza, C, Joanna F. McGouran, Deepthi Menon, Jedrychowski, Mark P., Modis, Louise K., Kunji, Edmund R. S., Martin S. King, Dinkova-Kostova, Albena T.; id_orcid, Luke A. O’Neill, Ashford, Michael L.J., Fischer, Roman, Chouchani, Edward T., Kunji, ERS, Sévin, DC, Costa, Ana S. H., Ryan, DG, Frezza, Christian, Michael L. J. Ashford, Knatko, Elena V., Prag, Hiran A.; id_orcid, Brunori, Gino, Albena T. Dinkova-Kostova, McGettrick, AF, Hughes, Mark M., Zbigniew Zaslona, Hartley, Richard C., McGouran, Joanna F., King, Martin A., McGouran, JF, Mark P. Jedrychowski, Mark M. Hughes, Richard C. Hartley, Costa, Ana S.H., Meakin, Paul J., Szpyt, J, Meakin, PJ, Menon, D, Evanna L. Mills, King, MS, Fallon, PG, Murphy, Michael P., Mills, Evanna L., Higgins, Maureen, Christian Frezza, Szpyt, John, Dikovskaya, Dina, Benedikt M. Kessler, Mills, EL, Hartley, RC, O'Neill, LA, Gino Brunori, O’Neill, LA, Richard G. Carroll, Dinkova-Kostova, AT, Padraic G. Fallon, Jedrychowski, MP, Knatko, EV, Caldwell, ST, Edmund R. S. Kunji, Runtsch, Marah C., Costa, ASH, Elena V. Knatko, Michael P. Murphy, Daniel C. Sévin, Prag, Hiran A., Caldwell, Stuart T., McGettrick, Anne F., Emily Hams, Murphy, MP, Paul J. Meakin, Chouchani, ET, Hughes, MM, O’Neill, Luke A., Modis, LK, Meakin, Paul J.; id_orcid, Ana S. H. Costa, Higgins, M, Carroll, RG, Ashford, Michael L. J., Dikovskaya, D, Fischer, R, Booty, Lee M., Fallon, Padraic G., Dylan G. Ryan, Booty, LM, Brunori, G, Marah C. Runtsch, Ryan, Dylan G., Maureen Higgins, John Szpyt, Ashford, Michael L. J.; id_orcid, Edward T. Chouchani, Sévin, Daniel C., Kessler, Benedikt M., Runtsch, MC, Hiran A. Prag, Lee M. Booty, Dina Dikovskaya, Kunji, Edmund R.S., Zaslona, Zbigniew   +116 more
core   +2 more sources

Mechanistic Pathways of Wound Healing: From Hemostasis to Scar‐Free Regeneration

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Wound healing is the critical process regulated through a harmonious coordination of cellular, molecular, pathological, and systemic communications. Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways.
Devadass Jessy Mercy, Koyeli Girigoswami, Agnishwar Girigoswami   +2 more
wiley   +1 more source

Protocol to study the role of endogenously produced itaconate using CRISPR-Cas9 technology in THP-1 cells

STAR Protocols
Summary: Itaconate mimetics inadequately represent endogenous itaconate, a negative regulator of innate immune-driven pro-inflammatory cytokines. We present a CRISPR-Cas9 protocol to delete a 4-nucleotide region in the immunoresponsive gene 1 (IRG1 ...
Luke A. Bourner, Katie A. Acken, Haiyan Long, Linda A. Chung, Kenneth D. Roth, Frank C. Dorsey   +5 more
doaj   +1 more source