Results 71 to 80 of about 4,169 (171)
Process engineering of pH tolerant Ustilago cynodontis for efficient itaconic acid production
Microbial Cell Factories, 2019 Background Ustilago cynodontis ranks among the relatively unknown itaconate production organisms. In comparison to the well-known and established organisms like Aspergillus terreus and Ustilago maydis, genetic engineering and first optimizations for ...
Hamed Hosseinpour Tehrani +4 more
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Offense and defense: itaconate mediates bidirectional immune regulation of host-bacteria interaction
Journal of Biomedical ScienceItaconate has garnered significant attention in recent years due to its immunomodulatory and antimicrobial functions. During inflammation and pathogenic infections, itaconate is formed through the decarboxylation of cis-aconitate in the mitochondrial ...
Zhaoyue Men +5 more
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Reaction between Itaconic Acid and Vinyl Acetate, and Synthesis of Polyvinyl Itaconate
The Journal of the Society of Chemical Industry, Japan, 1963 イタコン酸の反応の一つとして,イタコン酸と酢酸ビニルとの反応によって,ビニルエステルを得る可能性を検討するために両者の反応を行なった。さらにポリビニルアルコールと無水イタコン酸との反応によってポリビニルイタコネートを得た。反応方法はイタコン酸と酢酸ビニルとの反応では,Adelmanのビニル交換反応の方法に従って,イタコン酸を酢酸ビニル中に加え,硫酸水銀(II)を触媒にして常温放置または沸点で熱して行なった。ポリビニルイタコネートは無水イタコン酸とポバールを酢酸中(酢酸ナトリウムを加え)または,ジメチルホルムアミド中でピリジンを触媒として熱して得られた。結果はイタコン酸と酢酸ビニルの反応では酢酸ビニル,アセトアルデヒド,酢酸等の低留分を留去した後,減圧蒸留すると ...
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Control of immune cell signaling by the immuno-metabolite itaconate
Frontiers in ImmunologyImmune cell activation triggers signaling cascades leading to transcriptional reprogramming, but also strongly impacts on the cell’s metabolic activity to provide energy and biomolecules for inflammatory and proliferative responses. Macrophages activated
Roland Lang +2 more
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Journal of Inflammation Research, 2021 Yanan Xu,1,* Zihao Li,1,* Shounan Lu,2 Chaoqun Wang,2 Shanjia Ke,2 Xinglong Li,2 Bing Yin,2 Hongjun Yu,2 Menghua Zhou,1 Shangha Pan,3 Hongchi Jiang,1 Yong Ma2 1Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of Hepatic ...
Xu Y +11 more
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Metabolic Engineering CommunicationsIncorporation of irreversible steps in pathway design enhances the overall thermodynamic favorability and often leads to better bioconversion yield given functional enzymes.
Ryan S. Wang +4 more
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Cancer cell-intrinsic biosynthesis of itaconate promotes tumor immunogenicity
The EMBO JournalThe Krebs cycle byproduct itaconate has recently emerged as an important metabolite regulating macrophage immune functions, but its role in tumor cells remains unknown.
Zining Wang +15 more
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Itaconate and dimethyl itaconate upregulate IL-6 production in the LPS-induced inflammation in mice
Journal of Leukocyte BiologyAbstract Itaconate is one of the most studied immunometabolites produced by myeloid cells during inflammatory response. It mediates a wide range of anti-inflammatory and immunoregulatory effects and plays a role in a number of pathological states, including autoimmunity and cancer.
Maxim, Nosenko +9 more
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Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia.
PLoS PathogensMycoplasma pneumoniae is a common cause of community-acquired pneumonia in which neutrophils play a critical role. Immune-responsive gene 1 (IRG1), responsible for itaconate production, has emerged as an important regulator of inflammation and infection,
Cui Wang +13 more
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