Results 81 to 90 of about 6,203 (152)

Amino Acid Metabolism in Health and Disease

MedComm, Volume 7, Issue 9, September 2026.
This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su, Jinyu Liu, Xiaoliang Deng, Yanqun Luo, Haiping Xue, Lei Wang, Lianjun Xing, Tao Wu   +7 more
wiley   +1 more source

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

Nature Communications, 2019
Redirection of the TCA cycle intermediate aconitate to itaconate production has anti-inflammatory effects. Here the authors show that the itaconate derivative 4-octyl-itaconate is anti-inflammatory partly as a result of inhibiting GAPDH enzymatic ...
Shan-Ting Liao, Chao Han, Ding-Qiao Xu, Xiao-Wei Fu, Jun-Song Wang, Ling-Yi Kong   +5 more
doaj   +1 more source

Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice

The Journal of Clinical Investigation
Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the enzyme that synthesizes it, aconitate decarboxylase 1 (Acod1, also known as
Jianrui Song, Yanling Zhang, Ryan A. Frieler, Anthony Andren, Sherri Wood, Daniel J. Tyrrell, Peter Sajjakulnukit, Jane C. Deng, Costas A. Lyssiotis, Richard M. Mortensen, Morgan Salmon, Daniel R. Goldstein   +11 more
doaj   +1 more source

Itaconate production by Ustilago maydis : the influence of genes and cultivation conditions [PDF]

, 2013
Due to the increasing CO2 emissions and the necessity for substitutions to the petrochemical fuels, the interest in biofuels originating from alternative renewable resources is on the rise. Itaconate represents a newly identified platform molecule, which
Maasem Panakova, Monika
core  

Itaconate and its derivatives ameliorate autoimmunity by suppressing Th17 cells via regulating mitophagy

Cell Communication and Signaling
Itaconate (ITA) originates by decarboxylation of cis-aconitate catalyzed by the enzyme aconitate decarboxylase 1. It has immunomodulatory properties, but its role in T cells, especially CD4+ T cells, is mostly unexplored. Here, we examined the effects of
Fuli Li, Qing Huang, Naisheng Zheng, Wenyu Zhang, Shan Luo, Ruowen Wang, Thulasiram Bathini, Pengkai Sun, Xinjian Li, Xian Huang, Tomasz Maj   +10 more
doaj   +1 more source

Metabolic engineering of Escherichia coli for itaconate production [PDF]

, 2016
Interest in sustainable development together with limited amounts of fossil resources have increased the demand for production of chemicals and fuels from renewable resources.
Vuoristo, K.S.
core  

Process engineering of pH tolerant Ustilago cynodontis for efficient itaconic acid production

Microbial Cell Factories, 2019
Background Ustilago cynodontis ranks among the relatively unknown itaconate production organisms. In comparison to the well-known and established organisms like Aspergillus terreus and Ustilago maydis, genetic engineering and first optimizations for ...
Hamed Hosseinpour Tehrani, Katharina Saur, Apilaasha Tharmasothirajan, Lars M. Blank, Nick Wierckx   +4 more
doaj   +1 more source

Engineering thioesterase as a driving force for novel itaconate production via its degradation scheme

Metabolic Engineering Communications
Incorporation of irreversible steps in pathway design enhances the overall thermodynamic favorability and often leads to better bioconversion yield given functional enzymes.
Ryan S. Wang, Siang-Wun Siao, Jessica C. Wang, Patrick Y. Lin, Claire R. Shen   +4 more
doaj   +1 more source

‐butyl itaconate during water absorption/desorption cycles

, 2012
This study evaluated the water absorption, solubility, kinetics of water diffusion and residual monomer content of commercial poly(methyl methacrylate) (PMMA) denture base material modified with dimethyl itaconate (DMI) and di-n-butyl itaconate (DBI ...
Svetlana Grujić, Pjanović, Rada, Sava Veličković, Bošković-Vragolović, Nevenka, Pavle Spasojević, Dragoslav Stamenković, Stamenković, Dragoslav, Spasojević, Pavle, Nevenka Bošković‐Vragolović, Grujić, Svetlana, Rada Pjanović, Dolić, Jelena, Veličković, Sava, Jelena Dolić   +13 more
core   +1 more source

Cancer cell-intrinsic biosynthesis of itaconate promotes tumor immunogenicity

The EMBO Journal
The Krebs cycle byproduct itaconate has recently emerged as an important metabolite regulating macrophage immune functions, but its role in tumor cells remains unknown.
Zining Wang, Lei Cui, Yanxun Lin, Bitao Huo, Hongxia Zhang, Chunyuan Xie, Huanling Zhang, Yongxiang Liu, Huan Jin, Hui Guo, Mengyun Li, Xiaojuan Wang, Penghui Zhou, Peng Huang, Jinyun Liu, Xiaojun Xia   +15 more
doaj   +1 more source