Results 61 to 70 of about 6,203 (152)
Itaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2. [PDF]
, 2022 peer reviewedMacrophages undergo extensive metabolic reprogramming during classical pro-inflammatory polarization (M1-like). The accumulation of itaconate has been recognized as both a consequence and mediator of the inflammatory response.
BRENNER, Dirk +16 more
core +1 more source
From Molecular Targets to Advanced Delivery Systems: Aptamers for Precision Ocular Therapeutics
Advanced Therapeutics, Volume 9, Issue 10, October 2026.Aptamer‐based strategies are revolutionizing ocular disease management through highly specific molecular recognition of disease specific molecular targets. This review systematically integrates therapeutic aptamer sequences, diagnostic aptasensor platforms, and targeted delivery strategies, highlighting design principles, ocular bioavailability ...
Minal Thacker +4 more
wiley +1 more source
Biomass feedstock is an accessible alternative to finite fossil chemical resources for fabricating durable and high-performance polymers. In this study, fully biobased poly(1,5-pentylene succinate-co-itaconate-co-furanoate) (PPeSIFs) copolyesters were ...
Liqun Zhang (115900) +8 more
core +1 more source
Efficient itaconic acid production from glycerol with Ustilago vetiveriae TZ1
Biotechnology for Biofuels, 2017 Background The family of Ustilaginaceae is known for their capability to naturally produce industrially valuable chemicals from different carbon sources.
Thiemo Zambanini +9 more
doaj +1 more source
Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management
MedComm, Volume 7, Issue 10, October 2026.A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley +1 more source
Metabolic engineering of $Corynebacterium$ $glutamicum$ for the production of itaconate
, 2015 The capability of Corynebacterium glutamicum for glucose-based synthesis of itaconate was explored, which can serve as building block for production of polymers, chemicals, and fuels. C.
Otten, Andreas +2 more
core +1 more source
Cell Death Discovery, 2022 Itaconate, a metabolite produced during inflammatory macrophage activation, has been extensively described to be involved in immunoregulation, oxidative stress, and lipid peroxidation.
Ruyuan He +11 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang +4 more
wiley +1 more source
In vivo itaconate tracing reveals degradation pathway and turnover kinetics [PDF]
Itaconate is an immunomodulatory metabolite that alters mitochondrial metabolism and immune cell function. This organic acid is endogenously synthesized by tricarboxylic acid (TCA) metabolism downstream of TLR signalling.
Cordes, Thekla +9 more
core +1 more source
Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation
eLifeOne primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate.
Rabina Mainali +6 more
doaj +1 more source