Results 61 to 70 of about 4,169 (171)

Itaconate alleviates diet-induced obesity via activation of brown adipocyte thermogenesis

Cell Reports
Summary: Despite medical advances, there remains an unmet need for better treatment of obesity. Itaconate, a product of the decarboxylation of the tricarboxylic acid cycle intermediate cis-aconitate, plays a regulatory role in both metabolism and ...
Zihan Yu, Xianju Li, Yanni Quan, Jiawen Chen, Jiarui Liu, Nairen Zheng, Shuwen Liu, Yini Wang, Wanlin Liu, Chen Qiu, Yi Wang, Ruimao Zheng, Jun Qin   +12 more
doaj   +1 more source

Batteries From Reused, Recycled, and Surplus Materials

Advanced Sustainable Systems, Volume 10, Issue 7, July 2026.
Batteries can become more circular by combining reuse, direct recycling, metallurgical recovery, and material sourcing from industrial surplus streams. This Review highlights how recycled and waste‐derived metals, carbons, polymers, electrolytes, and active materials can be reintegrated into current and emerging batteries, while emphasizing design ...
Jing Yu, Irina Martynova, Elsa Briqueleur, Michael Carboni, Pascale Chenevier, Giulia Pezzin, Yuchuan Ren, Malik Dilshad Khan, Zeyan Li, Marja Vilkman, Chamseddine Guizani, Mickael Dolle, Gian Andrea Blengini, Jordi Jacas, Jordi Arbiol, Andreu Cabot, Alessandra Manzini   +16 more
wiley   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

Nature Communications, 2019
Redirection of the TCA cycle intermediate aconitate to itaconate production has anti-inflammatory effects. Here the authors show that the itaconate derivative 4-octyl-itaconate is anti-inflammatory partly as a result of inhibiting GAPDH enzymatic ...
Shan-Ting Liao, Chao Han, Ding-Qiao Xu, Xiao-Wei Fu, Jun-Song Wang, Ling-Yi Kong   +5 more
doaj   +1 more source

Dynamic mechanical and dielectric relaxations in poly(dibenzyl itaconate) and poly(diethylphenyl itaconate)

Polymer, 2000
Abstract Dynamic mechanical and dielectric behaviour of poly(dibenzyl itaconate), and poly(diethylphenyl itaconate) were studied. The study was performed by determining the components of the complex relaxation modulus E∗ and the complex dielectric permittivity e∗.
Calleja, RD, Martinez Pina, F, Gargallo, L, Radic, D   +3 more
openaire   +6 more sources

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, Volume 13, Issue 38, 9 July 2026.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Serum Proteomic Signatures of Rheumatoid Arthritis Risk and Response: Analysis of a Rheumatoid Arthritis Interception Trial

Arthritis &Rheumatology, Volume 78, Issue 7, Page 1403-1413, July 2026.
Objective Our study objective was to identify serum protein signatures associated with progression to rheumatoid arthritis (RA) and response to abatacept in at‐risk individuals. Methods A total of 440 serum samples from 118 APIPPRA (Arthritis Prevention In the Preclinical Phase of RA with Abatacept) study participants were selected from baseline to RA ...
Marianna Jasenecova, Carl Coyle, Alina Mihalovits, Sarah Ryan, Elizabeth Pook, Esperanza Perucha, Gabrielle Harker, Melody Chin, Sam Norton, Andrew P. Cope   +9 more
wiley   +1 more source

Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

JCI Insight, 2023
Modulation of the immune response to initiate and halt the inflammatory process occurs both at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in regulating cell fate and function, tendon injuries that undergo ...
Janna L. Crossley, Sonya Ostashevskaya-Gohstand, Stefano Comazzetto, Jessica S. Hook, Lei Guo, Neda Vishlaghi, Conan Juan, Lin Xu, Alexander R. Horswill, Gerta Hoxhaj, Jessica G. Moreland, Robert J. Tower, Benjamin Levi   +12 more
doaj   +1 more source

Microglial Mitochondrial Dysfunction: The Storm Center of Post‐Stroke Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Stroke disrupts microglial mitochondrial homeostasis, leading to acute damage and metabolic dysfunction that amplify pro‐inflammatory signaling. Although quality control mechanisms initiate protective responses, persistent stress overwhelms them. The resulting imbalance drives a self‐reinforcing neuroinflammatory storm that exacerbates secondary brain ...
Ruchong Fan, Chuan Wang, Zi Lin, Shiling Chen, Chao Pan, Hao Nie, Chuan Qin, Xuan Wu, Zhouping Tang   +8 more
wiley   +1 more source

Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice

The Journal of Clinical Investigation
Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the enzyme that synthesizes it, aconitate decarboxylase 1 (Acod1, also known as
Jianrui Song, Yanling Zhang, Ryan A. Frieler, Anthony Andren, Sherri Wood, Daniel J. Tyrrell, Peter Sajjakulnukit, Jane C. Deng, Costas A. Lyssiotis, Richard M. Mortensen, Morgan Salmon, Daniel R. Goldstein   +11 more
doaj   +1 more source