Results 91 to 100 of about 6,203 (152)

Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia.

Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in which neutrophils play a critical role. Immune-responsive gene 1 (IRG1), responsible for itaconate production, has emerged as an important regulator of inflammation and infection,
Ying Luo, Cuiming Zhu, Yujun Zhou, Kang Zheng, Chuan Wang, Cui Wang, Aihua Lei, Zhenkui Li, Jun Wen, Yimou Wu, Nan Ding, Haijun Zhang, Zijun Yan, Zhande Gong   +13 more
core   +1 more source

Protective role of IRG1/itaconate in acute myocardial injury: association with NLRP3 inflammasome and oxidative stress

Scientific Reports
Increasing evidence indicates the critical role of Immune response gene 1 (IRG1)-derived itaconate in metabolic regulation and signal transduction, with therapeutic implications for inflammatory diseases.
Hui Chen, Kerui Fan, Shu Xiang, Nian Zeng, Hui Wen, Jun Cai, Kun Chen, Xiaojiao He   +7 more
doaj   +1 more source

Dimethyl itaconate suppresses dendritic cell and CD8+ T cell responses to halt vitiligo

BMC Medicine
Background Although dendritic cell (DC)- and CD8+ T cell-mediated autoimmunity is critical for destroying melanocytes in vitiligo, treatment options remain limited by the absence of therapies that cotarget both cell types.
Yinghan Wang, Yuhan Chen, Jingjing Ma, Linxuan Wu, Pan Kang, Jianru Chen, Pengran Du, Wei Wu, Xinju Wang, Kaiqiao He, Yuqi Yang, Sen Guo, Weinan Guo, Ling Liu, Zhe Jian, Tianwen Gao, Shuli Li, Chunying Li   +17 more
doaj   +1 more source

Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane

Signal Transduction and Targeted Therapy
Metabolic reprogramming of host cells plays critical roles during viral infection. Itaconate, a metabolite produced from cis-aconitate in the tricarboxylic acid cycle (TCA) by immune responsive gene 1 (IRG1), is involved in regulating innate immune ...
Shulei Yin, Yijie Tao, Tianliang Li, Chunzhen Li, Yani Cui, Yunyan Zhang, Shenhui Yin, Liyuan Zhao, Panpan Hu, Likun Cui, Yunyang Wu, Yixian He, Shu Yu, Jie Chen, Shaoteng Lu, Guifang Qiu, Mengqi Song, Qianshan Hou, Cheng Qian, Zui Zou, Sheng Xu, Yizhi Yu   +21 more
doaj   +1 more source

4-Octyl Itaconate Promotes Diabetic Wound Healing by Enhancing Pro-Resolving Macrophages via the Efferocytosis-MCT1-Lactate-GPR132 Pathway and Macrophage-Independent Synergistic Effects (Diabetes Metab J 2026;50:707-23). [PDF]

Diabetes Metab J
Tu M, Zou X, Long Y, Xu Y.
europepmc   +2 more sources

Itaconate-loaded metal–organic framework (MOF) nanomedicine for the sustained treatment of intervertebral disk degeneration

APL Materials
Intervertebral disk degeneration (IVDD) is a major cause of spinal pathology and pain and can lead to disability in adults in severe cases. The medication against disk degeneration is limited due to the lack of therapeutic drugs and ineffective delivery ...
Haixin Song, Jianhua Li, Qibin Zhang, Bingjie Zheng, Changsheng Li, Yiran Wang, Jian Chen, Junhui Liu, Tao Wu, Xiaotian Yang, Xueqian Kong, Fengdong Zhao   +11 more
doaj   +1 more source

Itaconate and its derivatives in human health and diseases. [PDF]

Signal Transduct Target Ther
Gu J, Zhang W, Zhang J, Zeng S, Xia R, Cai L, Zhong X, Guo S, Wang H, Chen ZS.   +9 more
europepmc   +1 more source

Itaconate alleviates thioacetamide-induced acute liver injury by suppressing pyroptosis-associated mitochondrial dysfunction and activating the Nrf2/HO-1 pathway. [PDF]

Front Pharmacol
Lv L, Yang W, Yu Q, Ma Z, Wang S, Lu Y.
europepmc   +1 more source

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8. [PDF]

Exp Mol Med
Qian J, Tan Z, Wang J, Wei T, Huang C, Cheng S, Zhong G, Zou H, Kang X, Sun L, Zhang Y.   +10 more
europepmc   +1 more source

Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis. [PDF]

Nat Metab
Tang J, Pernes G, Nakagaki B, Tran N, Bokor L, Prenen F, Yi M, Robertson AE, Cronin R, Sarmini M, Pierscianowski J, Roberts V, Ryback BA, Novina CD, Auclair K, Xiao H, Mills EL.   +16 more
europepmc   +1 more source