Results 51 to 60 of about 233,572 (253)

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Succinate Dehydrogenase–Deficient Paraganglioma of the Prostate

Annals of Internal Medicine: Clinical Cases, 2023
Paragangliomas emerging in unusual locations may represent a diagnostic pitfall. We report clinical, genetic, imaging, and histopathologic features of succinate dehydrogenase–deficient paraganglioma arising within the prostate gland.
Gabriela Szuman, Lama Amer, Robert Hamilton, Ur Metser, Sylvia L. Asa, Ozgur Mete, Shereen Ezzat   +6 more
doaj   +1 more source

SDHD (succinate dehydrogenase complex II, subunit D, integral membrane protein) [PDF]

, 2002
Review on SDHD (succinate dehydrogenase complex II, subunit D, integral membrane protein), with data on DNA, on the protein encoded, and where the gene is ...
AP Gimenez-Roqueplo, Gimenez-Roqueplo, AP   +1 more
core   +1 more source

Identification of stable normalization genes for quantitative real-time PCR in porcine articular cartilage

Journal of Animal Science and Biotechnology, 2012
Background Expression levels for genes of interest must be normalized with an appropriate reference, or housekeeping gene, to make accurate comparisons of quantitative real-time PCR results.
McCulloch Ryan S, Ashwell Melissa S, O’Nan Audrey T, Mente Peter L   +3 more
doaj   +1 more source

Activation of succinate dehydrogenase by 2,4-dinitrophenol-a competitive inhibitor

, 1971
1.The reported inhibition of the succinate oxidase system at high concentrations of dinitrophenol, considered to be at the primary dehydrogenase level, is now confirmed by measuring the activity of succinate dehydrogenase (succinate:(acceptor ...
Susheela, L, Ramasarma, T
core   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

The emerging clinical relevance of genomic profiling in neuroendocrine tumours

BMC Cancer, 2021
Background Neuroendocrine tumours (NETs) arise from hormone-producing or nervous system cells and can develop from anywhere in the body. They have heterogeneous origins from skin to gastrointestinal track and a complicated histology.
Guney Isa Burak, Sonmezler Ozge, Mujde Cem, Buyukdereli Gulgun, Dogruca Yapar Zeynep, Bisgin Atil   +5 more
doaj   +1 more source

Enzymatic activity of succinate dehydrogenase (ETC complex II).

, 2017
Enzymatic activity of succinate dehydrogenase (ETC complex II).
Josef Schröder (3633601), Peter M. Schmid (514199), Alexander Dietl (3202908), Lars S. Maier (738314), Julian Hupf (3633604), Christoph Birner (3202905), Laura Grois (3633595), Andreas Luchner (258077), Jörg Reinders (559463), Carsten Jungbauer (3633598), Markus Resch (3633607)   +10 more
core   +1 more source

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. [PDF]

, 2016
peer reviewedMetabolic reprogramming is emerging as a hallmark of the innate immune response, and the dynamic control of metabolites such as succinate serves to facilitate the execution of inflammatory responses in macrophages and other immune cells ...
Koseki, Haruhiko, SOUSA, Carole, Wallace, Martina, Murphy, Anne N., Murphy, Anne N, Divakaruni, Ajit S, Metallo, Christian M., Cordes, Thekla, Sapcariu, Sean C., Hiller, Karsten, Cabrales, Pedro, MICHELUCCI, Alessandro, Sapcariu, Sean C, Metallo, Christian M, Divakaruni, Ajit S.   +14 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source