Results 1 to 10 of about 205,948 (159)

Proton coupled electron transport of pH sensitive coumarin based ruthenium(II) complex: A functional mimic of photosystem II

Journal of Photochemistry and Photobiology, 2021
In this work, we have explored a new pH sensitive coumarin based ruthenium(II) complex (R1QC) to mimic the role of P680 in donor side of photosystem II in natural photosynthesis.
Anish Babu Athanas, Swarnalatha Kalaiyar
doaj   +4 more sources

Electron Transport Chain Complex II Regulates Steroid Metabolism

iScience, 2020
Summary: The first steroidogenic enzyme, cytochrome P450-side-chain-cleavage (SCC), requires electron transport chain (ETC) complexes III and IV to initiate steroid metabolic processes for mammalian survival.
Himangshu S. Bose, Brendan Marshall, Dilip K. Debnath, Elizabeth W. Perry, Randy M. Whittal   +4 more
doaj   +3 more sources

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II. [PDF]

Blood, 2019
Abstract We have previously demonstrated that oxidative phosphorylation is required for the survival of human leukemia stem cells (LSCs) from patients with acute myeloid leukemia (AML). More recently, we demonstrated that LSCs in patients with de novo AML rely on amino acid metabolism to drive oxidative phosphorylation. Notably, although
Jones CL, Stevens BM, D'Alessandro A, Culp-Hill R, Reisz JA, Pei S, Gustafson A, Khan N, DeGregori J, Pollyea DA, Jordan CT.   +10 more
europepmc   +3 more sources

Protocol for direct measurement of stability and activity of mitochondria electron transport chain complex II

STAR Protocols, 2023
Summary: Mitochondria electron transport chain (ETC) complex II is essential for steroid metabolism. Here, we present a protocol to measure the stability and activity of mitochondria ETC complex II.
Himangshu S. Bose, Nicole E. Doetch
doaj   +3 more sources

Electron transport chain complex II sustains high mitochondrial membrane potential in hematopoietic stem and progenitor cells

Stem Cell Research, 2019
The role of mitochondria in the fate determination of hematopoietic stem and progenitor cells (HSPCs) is not solely limited to the switch from glycolysis to oxidative phosphorylation, but also involves alterations in mitochondrial features and properties,
Claudia Morganti, Massimo Bonora, Kyoko Ito, Keisuke Ito   +3 more
doaj   +4 more sources

Inhibitory Effect of ATP on Cytochrome c Oxidase Depends on Electron Entry Pathways by TCA Cycle Metabolites [PDF]

Cells
The ATP-dependent inhibition of cytochrome c oxidase (CytOx, complex IV of the electron transport chain) is the second mechanism of respiratory control adjusting mitochondrial respiration in order to prevent excessive electron flow and reactive oxygen ...
Madeline Günther, Valeria Pakic, Petra Weber, Anke Veit, Carsten Culmsee, Ardawan J. Rastan, Annegret P. Busch, Sebastian Vogt   +7 more
doaj   +2 more sources

Acid enhancement of ROS generation by complex-I reverse electron transport is balanced by acid inhibition of complex-II: Relevance for tissue reperfusion injury

Redox Biology, 2020
Generation of mitochondrial reactive oxygen species (ROS) is an important process in triggering cellular necrosis and tissue infarction during ischemia-reperfusion (IR) injury. Ischemia results in accumulation of the metabolite succinate. Rapid oxidation
Alexander S. Milliken, Chaitanya A. Kulkarni, Paul S. Brookes   +2 more
doaj   +3 more sources

Direct dapagliflozin exposure enhances respiration and membrane hyperpolarization in isolated cardiac mitochondria [PDF]

Frontiers in Physiology
Dapagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor widely used for the treatment of diabetes, has been consistently associated with cardiovascular protection, including attenuation of ischemia/reperfusion injury and reduced incidence of ...
Itanna Isis Araújo de Souza, César Francisco Maricato da Rosa, Laís Eduardo Marinho, Marcella Borges Coutinho, Caroline Da Silva Moraes, Antonio Carlos Campos de Carvalho, José Hamilton Matheus Nascimento, Leonardo Maciel de Oliveira Pinto, Leonardo Maciel de Oliveira Pinto, Leonardo Maciel de Oliveira Pinto   +9 more
doaj   +2 more sources

Impact of mitochondrial reductive stress due to respiratory chain limitation on cancer via posttranslational modifications [PDF]

Redox Biology
Respiratory chain limitation is a recurrent but spatially heterogeneous state in solid tumors, driven by hypoxic subregions, electron transport chain defects, and signaling- or therapy-imposed respiratory inhibition.
Christos Chinopoulos
doaj   +2 more sources

Siccanin Is a Dual-Target Inhibitor of Plasmodium falciparum Mitochondrial Complex II and Complex III

Pharmaceuticals, 2022
Plasmodium falciparum contains several mitochondrial electron transport chain (ETC) dehydrogenases shuttling electrons from the respective substrates to the ubiquinone pool, from which electrons are consecutively transferred to complex III, complex IV ...
Keisuke Komatsuya, Takaya Sakura, Kazuro Shiomi, Satoshi Ōmura, Kenji Hikosaka, Tomoyoshi Nozaki, Kiyoshi Kita, Daniel Ken Inaoka   +7 more
doaj   +1 more source