Results 21 to 30 of about 1,131,860 (291)
Sequencing covalent modifications of membrane proteins [PDF]
Journal of Experimental Botany, 2006 A number of strategies have successfully extended plant proteomics into the bilayer domain. Important benefits can be afforded by including a well-resolved intact protein mass spectrum alongside peptide identification experiments; recent studies of thylakoid membranes have yielded new information on the primary structure and covalent post-translational
Julian P, Whitelegge +5 more
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Technologies for Direct Detection of Covalent Protein–Drug Adducts
Pharmaceuticals, 2023 In the past two decades, drug candidates with a covalent binding mode have gained the interest of medicinal chemists, as several covalent anticancer drugs have successfully reached the clinic. As a covalent binding mode changes the relevant parameters to
Elma Mons +2 more
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Bioactivation of SERMs to reactive metabolites and protein covalent modification by quinoids.
, 2006 Bioactivation of SERMs to reactive metabolites and protein covalent modification by ...
Ju. Liu (7983962)
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Regulation of G proteins by covalent modification [PDF]
Oncogene, 2001 Heterotrimeric G protein alpha,beta, and gamma subunits are subject to several kinds of co- and post-translational covalent modifications. Among those relevant to G protein-coupled receptor signaling in normal cell function are lipid modifications and phosphorylation. N-myristoylation is a co-translational modification occurring for members of the G(i)
C A, Chen, D R, Manning
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Nanoconfinement enabled non-covalently decorated MXene membranes for ion-sieving
Nature Communications, 2023 Covalent modification is commonly used to tune the channel size and functionality of 2D membranes. However, common synthesis strategies used to produce such modifications are known to disrupt the structure of the membranes.
Yuan Kang +12 more
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Weighing the Proteasome for Covalent Modifications
Chemistry & Biology, 2015 Posttranslational modifications (PTMs) control protein function, but established peptide-based proteomic methods often fail to provide a comprehensive view of PTMs. In this issue of Chemistry & Biology, Gersch et al. describe an efficient combination of chromatographic separation and top-down mass spectrometry that together with an intuitive ...
Birner-Gruenberger, Ruth +1 more
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Nature Communications, 2022 Covalent linkages are the key component of covalent organic frameworks (COFs) and the development of stable and functional linkages is essential to broaden their application prospects. Here, the authors report the synthesis of crystalline and ultrastable
Yongliang Yang +5 more
doaj +1 more source
Biotechnology Reports, 2019 Chemical modification of lysozyme was carried out using benzaldehyde and anisaldehyde. It was shown that chemical modification affects only 1–2 amino groups of the protein molecule which does not prevent further covalent immobilization of lysozyme using ...
Pavel A. Levashov +8 more
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Dimethyl Fumarate Induces Metabolic Crisie to Suppress Pancreatic Carcinoma
Frontiers in Pharmacology, 2021 Dimethyl fumarate (DMF) is an approved drug used in the treatment of multiple sclerosis (MS) and psoriasis therapy. Multiple studies have demonstrated other pharmacological activities of DMF such as an anti-cancer agent. In particular, studies have shown
Kaiyuan Chen +12 more
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Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone [PDF]
Journal of the Serbian Chemical Society, 2007 The quinone avarone, isolated from the marine sponge Dysidea avara, possesses the ability to chemically modify proteins. In this work, modification of lectin isolated from the coral Gerardia savaglia by avarone was examined.
IVANA PAJIC +5 more
doaj +3 more sources