Results 21 to 30 of about 166,609 (297)
Histone Deacetylase 1 Inhibition by Peptides Containing a DNA Damage-Induced, Nonenzymatic, Histone Covalent Modification. [PDF]
Biochemistry, 2023 Treatment of HeLa cells with the DNA damaging agent, bleomycin (BLM), results in the formation of a nonenzymatic 5-methylene-2-pyrrolone histone covalent modification on lysine residues (KMP).
Jacinto MP, Greenberg MM.
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Covalent lipid modifications of proteins [PDF]
Current Biology, 2013 SummaryAttachment of lipophilic groups is a widespread modification that occurs on nearly 1,000 proteins of diverse structure and function. At least five different types of lipids can be covalently attached to proteins: fatty acids, isoprenoids, sterols, phospholipids, and glycosylphosphatidyl inositol (GPI) anchors.
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Frontiers in Chemistry, 2021 Graphene-based nanocomposites constitute an interesting and promising material for various applications. Intensive progress in the development of this group of materials offers an opportunity to create new systems useful for drinking water ...
Michał Jakubczak +1 more
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Structural Transitions of Papain-like Cysteine Proteases: Implications for Sensor Development
Biomimetics, 2023 The significant role of papain-like cysteine proteases, including papain, cathepsin L and SARS-CoV-2 PLpro, in biomedicine and biotechnology makes them interesting model systems for sensor development.
Srdjan Marković +3 more
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Covalent modification of platelet proteins by palmitate [PDF]
Blood, 1989 Abstract Covalent attachment of fatty acid to proteins plays an important role in association of certain proteins with hydrophobic membrane structures. In platelets, the structure of many membrane glycoproteins (GPs) has been examined in detail, but the question of fatty acid acylation of platelet proteins has not been addressed. In this
L, Muszbek, M, Laposata
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Nature Communications, 2022 Covalent linkages are the key component of covalent organic frameworks (COFs) and the development of stable and functional linkages is essential to broaden their application prospects. Here, the authors report the synthesis of crystalline and ultrastable
Yongliang Yang +5 more
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Sequencing covalent modifications of membrane proteins [PDF]
Journal of Experimental Botany, 2006 A number of strategies have successfully extended plant proteomics into the bilayer domain. Important benefits can be afforded by including a well-resolved intact protein mass spectrum alongside peptide identification experiments; recent studies of thylakoid membranes have yielded new information on the primary structure and covalent post-translational
Julian P, Whitelegge +5 more
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Biotechnology Reports, 2019 Chemical modification of lysozyme was carried out using benzaldehyde and anisaldehyde. It was shown that chemical modification affects only 1–2 amino groups of the protein molecule which does not prevent further covalent immobilization of lysozyme using ...
Pavel A. Levashov +8 more
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Nanoconfinement enabled non-covalently decorated MXene membranes for ion-sieving
Nature Communications, 2023 Covalent modification is commonly used to tune the channel size and functionality of 2D membranes. However, common synthesis strategies used to produce such modifications are known to disrupt the structure of the membranes.
Yuan Kang +12 more
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, 2020 Targeted Covalent Inhibitors bind to their targets both covalent and non-covalent modes, providing exceptionally high affinity and selectivity. These inhibitors have been effectively employed as inhibitors of protein kinases, with Taunton and coworkers ...
Christopher, Rowley +1 more
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