Results 51 to 60 of about 166,609 (297)
Implications of Widespread Covalent Modification of mRNA [PDF]
Circulation Research, 2012 Whole transcriptome analysis reveals that one third of human and mouse genes express mRNAs containing methylated adenosines. Fat mass and obesity-associated ( FTO ) gene, a risk gene for obesity and metabolic abnormalities, demethylates the modified residues, suggesting a link between RNA methylation and disease.
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
STAR Protocols, 2021 Summary: Typical enzymatic inhibition assays often demonstrate improved potency for kinase covalent inhibitors compared to reversible inhibitors. This can primarily be attributed to the irreversible mode of action and could affect the evaluations of the ...
Martin Schröder, Apirat Chaikuad
doaj +1 more source
Non-covalent surface modification of cellulose nanocrystals by polyethyleneimine [PDF]
, 2018 : Cellulose nanocrystals (CNCs) are bio-derived, natively hydrophilic nanomaterials that disperse well in water according to their surface chemistry upon extraction.
Khandal, Dhriti +6 more
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Proteomic Analysis of Covalent Modifications of Tubulins by Isothiocyanates [PDF]
The Journal of Nutrition, 2012 Although isothiocyanates (ITC), which are found in cruciferous vegetables, have been shown to inhibit carcinogenesis in animal models and induce apoptosis and cell cycle arrest in tumor cells, the biochemical mechanisms of cell growth inhibition by these compounds are not fully understood.
Zhen, Xiao +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Macedonian Journal of Chemistry and Chemical Engineering, 2018 The past and recent uncontrolled use of organochlorine pesticides imposes serious problems due to their adverse undesired effects in ecosystems. Finding new ways to dispose of these molecules is therefore mandatory. The covalent modification of activated
Jeton Halili +2 more
doaj +1 more source
Characterization of Whey Protein Isolate Covalently Modified with Phenolic Compounds 2: Physiochemical and Emulsifying Properties [PDF]
Journal of Food and Dairy Sciences, 2019 This work was performed to study the effect of the covalent modifications of whey protein isolate (WP) by chlorogenic acid (CA) and rosmarinic acid (RA) on their physiochemical and emulsifying properties.
Salwa Arafa, M. Ali
doaj +1 more source
Quantum Chemical Methods for Modeling Covalent Modification of Biological Thiols
, 2019 Targeted covalent inhibitor drugs require computational methods that go beyond simple molecular-mechanical force fields in order to model the chemical reactions that occur when they bind to their targets.
William, Isley +7 more
core +1 more source