Results 51 to 60 of about 2,379,457 (382)

Covalent modification of platelet proteins by palmitate [PDF]

Blood, 1989
Abstract Covalent attachment of fatty acid to proteins plays an important role in association of certain proteins with hydrophobic membrane structures. In platelets, the structure of many membrane glycoproteins (GPs) has been examined in detail, but the question of fatty acid acylation of platelet proteins has not been addressed. In this
L, Muszbek, M, Laposata
openaire   +3 more sources

End-group functionalization of poly(2-oxazoline)s using methyl bromoacetate as initiator followed by direct amidation [PDF]

, 2019
Poly(2-alkyl/aryl-2-oxazoline)s (PAOx) are an alluring class of polymers for many applications due to the broad chemical diversity that is accessible for these polymers by simply changing the initiator, terminating agent and the monomer(s) used in their ...
Arys, Koen, Glassner, Mathias, Hoogenboom, Richard, Podevyn, Annelore, Retamero De La Rosa, Victor   +4 more
core   +2 more sources

Weighing the Proteasome for Covalent Modifications

Chemistry & Biology, 2015
Posttranslational modifications (PTMs) control protein function, but established peptide-based proteomic methods often fail to provide a comprehensive view of PTMs. In this issue of Chemistry & Biology, Gersch et al. describe an efficient combination of chromatographic separation and top-down mass spectrometry that together with an intuitive ...
Birner-Gruenberger, Ruth, Breinbauer, Rolf   +1 more
openaire   +2 more sources

Covalent Modifications of the Ebola Virus Glycoprotein [PDF]

Journal of Virology, 2002
ABSTRACT The role of covalent modifications of the Ebola virus glycoprotein (GP) and the significance of the sequence identity between filovirus and avian retrovirus GPs were investigated through biochemical and functional analyses of mutant GPs.
Scott A, Jeffers, David Avram, Sanders, Anthony, Sanchez   +2 more
openaire   +2 more sources

Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins.

Developmental Cell, 2020
Metabolites affect cell growth in two different ways. First, they serve as building blocks for biomass accumulation. Second, metabolites regulate the activity of growth-relevant signaling pathways.
G. Figlia, Philipp Willnow, A. Teleman
semanticscholar   +1 more source

Quantitative Irreversible Tethering (qIT) for Target-directed Covalent Fragment Screening

Bio-Protocol, 2020
Small molecules that react to form covalent bonds with proteins are widely used as biological tools and therapeutic agents. Screening cysteine-reactive fragments against a protein target is an efficient way to identify chemical starting points for ...
Gregory Craven, David Mann, Alan Armstrong   +2 more
doaj   +1 more source

Dimethyl Fumarate Induces Metabolic Crisie to Suppress Pancreatic Carcinoma

Frontiers in Pharmacology, 2021
Dimethyl fumarate (DMF) is an approved drug used in the treatment of multiple sclerosis (MS) and psoriasis therapy. Multiple studies have demonstrated other pharmacological activities of DMF such as an anti-cancer agent. In particular, studies have shown
Kaiyuan Chen, Shanshan Wu, Shanshan Wu, Sisi Ye, Sisi Ye, Huimin Huang, Yi Zhou, Hongfei Zhou, Shijia Wu, Yefan Mao, Fugen Shangguan, Linhua Lan, Bicheng Chen   +12 more
doaj   +1 more source

Thermodynamic and Kinetic Analysis of Sensitivity Amplification in Biological Signal Transduction [PDF]

, 2002
Based on a thermodynamic analysis of the kinetic model for the protein phosphorylation-dephosphorylation cycle, we study the ATP (or GTP) energy utilization of this ubiquitous biological signal transduction process.
Bourne, Ferrell, Goldbeter, Goldbeter, Gresser, Hartwell, Hill, Hill, Hopfield, Hopfield, Huang, Koshland, Koshland, Krebs, Kushmerick, Li, McKeithan, Poland, Qian, Qian, Shacter, Stadtman, Stryer, Wyman   +23 more
core   +5 more sources

Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone [PDF]

Journal of the Serbian Chemical Society, 2007
The quinone avarone, isolated from the marine sponge Dysidea avara, possesses the ability to chemically modify proteins. In this work, modification of lectin isolated from the coral Gerardia savaglia by avarone was examined.
IVANA PAJIC, ZORAN VUJCIC, MIROSLAVA VUJCIC, IRENA NOVAKOVIC, DUSAN SLADIC, MIROSLAV J. GASIC   +5 more
doaj   +3 more sources

Post-assembly modification of kinetically metastable Fe(II)2L3 triple helicates. [PDF]

, 2014
We report the covalent post-assembly modification of kinetically metastable amine-bearing Fe(II)2L3 triple helicates via acylation and azidation. Covalent modification of the metastable helicates prevented their reorganization to the thermodynamically ...
Ana M. Castilla, Ayme J.-F., Barker I. A., Barral K., Barran P. E., Berg J. M., Bilbeisi R. A., Bilbeisi R. A., Bonnet J. J., Bräse S., Bunzen H., Campbell V. E., Cangelosi V. M., Cangelosi V. M., Cangelosi V. M., Carnes M. E., Carpino L. A., Carpino L. A., Caulder D. L., Caulder D. L., Chakrabarty R., Chakrabarty R., Coles S. J., Davis A. V., Derrick A. Roberts, Dömer J., Frank M., Fujita M., Fuller A.-M., Fuller A.-M. L., Garibay S. J., Gianneschi N. C., Gody G., Golas P. L., Han S., Han Y.-F., Heinrich T., Jonathan R. Nitschke, Kaucher M. S., Kong G.-Q., Konkolewicz D., Korevaar P. A., Lehn J.-M., Leigh D. A., Lewis J., Lewis J. E. M., Ma Z., Mak C. C., Mosquera J., Ogi S., Ragnarsson U., Riddell I. A., Riddell I. A., Ronson T. K., Schneider M. W., Sham K.-C., Smulders M. M. J., Stang P. J., Sun M. H., Tanabe K. K., Tanya K. Ronson, Valeur E., Walsh C. T., Wang M., Whitesides G. M., Wu Y., Yi S., Young M. C., Zhao D., Zheng Y.-R., Zhou X.-P., Zhou X.-P.   +71 more
core   +3 more sources