Results 71 to 80 of about 1,131,860 (291)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Non-covalent surface modification of cellulose nanocrystals by polyethyleneimine [PDF]

, 2018
: Cellulose nanocrystals (CNCs) are bio-derived, natively hydrophilic nanomaterials that disperse well in water according to their surface chemistry upon extraction.
Khandal, Dhriti, Beuguel, Quentin, Heuzey, Marie-Claude, Tavares, Jason Robert, Riedl, Bernard, Carreau, Pierre, Zakeri, Bahareh   +6 more
core   +1 more source

Deciphering the phosphorylation of chitosan through complementary 1H and 31P{1H} DOSY NMR

Carbohydrate Polymer Technologies and Applications
Chemical modification of chitosan through phosphorylation has gained significant attention for expanding its applications. However, confirming whether phosphorylating agents form covalent bonds with the chitosan backbone or remain as non-covalently ...
Souhaib Abouricha, Cédric Totee, Steven Le Vot, Abdelouahd Oukhrib, Ouassim Ghodbane, Mohammed Lahcini, Frédéric Favier, Bruno Alonso, Hicham Ben Youcef   +8 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Attenuation of sensory receptor signaling by covalent modification. [PDF]

Proceedings of the National Academy of Sciences, 1992
The Tar receptor is a transmembrane protein that regulates bacterial chemotaxis in response to changes in the level of aspartic acid in the medium. The extracellular portion of the protein can bind aspartate, and the cytoplasmic portion modulates CheA kinase activity. The receptor can either activate or inhibit the kinase.
Borkovich, Katherine A., Alex, Lisa A., Simon, Melvin I.   +2 more
openaire   +4 more sources

Covalent sizing surface modification as a route to improved interfacial adhesion in carbon fibre-epoxy composites

, 2021
Covalent sizing surface modification as a route to improved interfacial adhesion in carbon fibre-epoxy ...
DJ Eyckens (14451150), Luke Henderson (13082367), Žan Simon (15905585), TR Gengenbach (14451156), J Pinson (13361616), CL Arnold (14451153), YA Wickramasingha (14451159)   +6 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Rho GTPase regulation by miRNAs and covalent modifications [PDF]

Trends in Cell Biology, 2012
To date, most studies of Rho GTPase regulation have focused on the classic GTPase cycle - GTP binding and hydrolysis - controlled by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs) and GDP-dissociation inhibitors (GDIs).
Ming, Liu, Feng, Bi, Xuan, Zhou, Yi, Zheng   +3 more
openaire   +2 more sources

Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX

eLife
We designed novel pre-drug compounds that transform into an active form that covalently modifies particular His residue in the active site, a difficult task to achieve, and applied to carbonic anhydrase (CAIX), a transmembrane protein, highly ...
Aivaras Vaškevičius, Denis Baronas, Janis Leitans, Agnė Kvietkauskaitė, Audronė Rukšėnaitė, Elena Manakova, Zigmantas Toleikis, Algirdas Kaupinis, Andris Kazaks, Marius Gedgaudas, Aurelija Mickevičiūtė, Vaida Juozapaitienė, Helgi B Schiöth, Kristaps Jaudzems, Mindaugas Valius, Kaspars Tars, Saulius Gražulis, Franz-Josef Meyer-Almes, Jurgita Matulienė, Asta Zubrienė, Virginija Dudutienė, Daumantas Matulis   +21 more
doaj   +1 more source