Results 71 to 80 of about 2,379,457 (382)

Effect of fibre treatments on interfacial shear strength of hemp fibre reinforced polylactide and unsaturated polyester composites [PDF]

, 2011
Surface treatment of hemp fibres was investigated as a means of improving interfacial shear strength (IFSS) of hemp fibre reinforced polylactide (PLA) and unsaturated polyester (UPE) composites. Fibres were treated with sodium hydroxide, acetic anhydride,
Fernyhough, Alan, Pickering, Kim L., Sawpan, Moyeenuddin Ahmad   +2 more
core   +2 more sources

Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.

Cell Chemical Biology, 2019
The Hippo pathway coordinates extracellular signals onto the control of tissue homeostasis and organ size. Hippo signaling primarily regulates the ability of Yap1 to bind and co-activate TEA domain (TEAD) transcription factors.
K. Bum-Erdene, Donghui Zhou, G. Gonzalez-Gutierrez, M. K. Ghozayel, Yubing Si, David Xu, H. Shannon, Barbara J. Bailey, T. Corson, K. Pollok, C. Wells, S. Meroueh   +11 more
semanticscholar   +1 more source

A novel covalent modification of nitrogenase in a cyanobacterium

FEBS Letters, 2000
In extracts of the unicellular cyanobacterium Gloeothece, the Fe‐protein of nitrogenase can be separated by SDS–PAGE into two antigenically identifiable components. Unlike the situation in photosynthetic bacteria such as Rhodospirillum rubrum, these two forms do not arise from covalent modification of the protein by ADP‐ribosylation.
Gallon, John R., Cheng, Jiujun, Dougherty, Lisa J., Gallon, Victoria A., Hilz, Helmuth, Pederson, Dennis M., Richards, Helen M., Rüggeberg, Sabrina, Smith, Christopher J.   +8 more
openaire   +2 more sources

Assessing reversible and irreversible binding effects of kinase covalent inhibitors through ADP-Glo assays

STAR Protocols, 2021
Summary: Typical enzymatic inhibition assays often demonstrate improved potency for kinase covalent inhibitors compared to reversible inhibitors. This can primarily be attributed to the irreversible mode of action and could affect the evaluations of the ...
Martin Schröder, Apirat Chaikuad
doaj   +1 more source

Nonthermal Plasma Technology as a Versatile Strategy for Polymeric Biomaterials Surface Modification: A Review [PDF]

, 2009
In modern technology, there is a constant need to solve very complex problems and to fine-tune existing solutions. This is definitely the case in modern medicine with emerging fields such as regenerative medicine and tissue engineering.
De Geyter, Nathalie, Desmet, Tim, Dubruel, Peter, Leys, Christophe, Morent, Rino, Schacht, Etienne   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Protein covalent modification by biologically active quinones [PDF]

Journal of the Serbian Chemical Society, 2004
The avarone/avarol quinone/hydroquinone couple shows considerable antitumor activity. In this work, covalent modification of b-lactoglobulin by avarone and its derivatives as well as by the synthetic steroidal quinone 2,5(10)-estradiene-1,4,17-trione and
MIROSLAV J. GASIC, BOGDAN SOLAJA, DRAGANA MILIC, TATJANA BOZIC, NATASA BOZIC, ZORAN VUJCIC, IRENA NOVAKOVIC, DUSAN SLADIC   +7 more
doaj  

Methodology of stable peptide based on propargylated sulfonium

Biochemistry and Biophysics Reports, 2023
Peptides can be used as effective molecular tool for covalent modification of proteins and play important roles in ligand directed covalent modification. Tyr-selective protein modifications exert a profound impact on protein functionality.
Heng Li, Zhanfeng Hou, Yuena Wang, Ziyuan Zhou, Jin Cai, Qilei Xin, Feng Yin, Zigang Li, Naihan Xu   +8 more
doaj   +1 more source

Evidence for electron transfer between graphene and non‐covalently bound π‐systems [PDF]

, 2020
Hybridizing graphene and molecules possess a high potential for developing materials for new applications. However, new methods to characterize such hybrids must be developed.
Brülls, Steffen M., Cantatore, Valentina, Eigler, Siegfried, Malmberg, Per, Mårtensson, Jerker, Panas, Itai, Sarkar, Biprajit, Stubbe, Jessica, Tam, Pui Lam, Wang, Zhenping   +9 more
core   +2 more sources

Implications of Widespread Covalent Modification of mRNA [PDF]

Circulation Research, 2012
Whole transcriptome analysis reveals that one third of human and mouse genes express mRNAs containing methylated adenosines. Fat mass and obesity-associated ( FTO ) gene, a risk gene for obesity and metabolic abnormalities, demethylates the modified residues, suggesting a link between RNA methylation and disease.
openaire   +2 more sources