Results 81 to 90 of about 1,131,860 (291)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Advances in covalent molecular glue degraders

生物医学转化
Covalent molecular glues represent a class of transformative candidate drugs in the field of targeted protein degradation (TPD). Unlike conventional non-covalent molecular glues that rely on reversible stabilization of protein-protein interfaces ...
Zhang Yunliang, Wang Zhen, Ding Ke
doaj   +1 more source

Covalent attachment of phenyl and carboxyphenyl layers derived from diazonium salts onto activated charcoal for the adsorption of pesticides

Macedonian Journal of Chemistry and Chemical Engineering, 2018
The past and recent uncontrolled use of organochlorine pesticides imposes serious problems due to their adverse undesired effects in ecosystems. Finding new ways to dispose of these molecules is therefore mandatory. The covalent modification of activated
Jeton Halili, Fexhrie Salihu, Avni Riza Berisha   +2 more
doaj   +1 more source

Covalent modification of enzymes for textile processes

, 2013
Dalfesoglu, ME. (2010). Covalent modification of enzymes for textile processes.
Dalfesoglu, Mehmet Emin
core  

Surface modification of carbon dots via peptide covalent conjugation

, 2023
Surface modification of carbon dots via covalent conjugation with a dipeptide resulted in a dramatic change in the fluorescence emission from green to red.
Banerjee A., Hazra N., Hazra S., Paul S.
core   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Enhanced proton conduction by post-synthetic covalent modification in a porous covalent framework

, 2017
Ether linkage based chemically stable porous covalent framework has been synthesized which upon post-synthetic modification presents a remarkably high proton conductivity (∼0.026 S cm−1) with an ∼130 fold enhancement compared to parent compound.
Sujit K. Ghosh, Partha Samanta, Sreekumar Kurungot, Aamod V. Desai, Mandar M. Shirolkar, Avishek Karmakar, Bihag Anothumakkool   +6 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine

eLife, 2016
Phenotypic screens allow the identification of small molecules with promising anticancer activity, but the difficulty in characterizing the mechanism of action of these compounds in human cells often undermines their value as drug leads.
Christopher Chidley, Sunia A Trauger, Kıvanç Birsoy, Erin K O'Shea   +3 more
doaj   +1 more source

Covalent Modification of N3 of Guanine by (+)-CC-1065 Results in Protonation of the Cross-Strand Cytosine

, 2016
Covalent Modification of N3 of Guanine by (+)-CC-1065 Results in Protonation of the Cross-Strand ...
Laurence H. Hurley (11747), Hyun-Ju Park (2025628)   +1 more
core   +1 more source