Results 101 to 110 of about 1,131,860 (291)
Protein-Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal [PDF]
, 2019 A new lysine‐reactive cyclopropropyl aldehyde for the covalent modification of proteins was developed. The reagent exploits a divinylcyclopropane‐cycloheptadiene rearrangement to render the initial condensation irreversible.
Christian P. R. Hackenberger (7833498) +9 more
core +2 more sources
Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling
FEBS Open Bio, EarlyView.Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt +2 more
wiley +1 more source
Modeling covalent-modifier drugs
, 2017 In this review, we present a summary of how computer modeling has been used in the development of covalent modifier drugs. Covalent modifier drugs bind by forming a chemical bond with their target. This covalent binding can improve the selectivity of the
Christopher N Rowley +2 more
core +2 more sources
Proteome‐wide identification of mycobacterial pupylation targets
Molecular Systems Biology, 2010 Mycobacteria use a unique system for covalently modifying proteins based on the conjugation of a small protein, referred to as prokaryotic ubiquitin‐like protein (PUP). In this study, we report a proteome‐wide analysis of endogenous pupylation targets in
Christian Poulsen +8 more
doaj +1 more source
Tuning the wettability and photoluminescence of graphene quantum dots via covalent modification
, 2018 In this paper, we have tuned the dual properties, i.e., wettability and photoluminescence of GQDs by simply covalent modification with long chain alkyl (–C12H27) groups.
Manash Jyoti Deka +2 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Covalent modification of hexokinase by biologically active quinones
, 2005 In this work, inhibition of sulfhydryl containing glycolytic enzyme hexokinase by avarone and its derivatives was studied. The enzyme contains lysine and sulfhydryl residues, which can be modified by the quinone moiety.
Novaković, Irena +3 more
core +2 more sources
Funcionalização de nanotubos de Carbono Functionalization of carbon nanotubes
Química Nova, 2007 Carbon nanotubes are very stable systems having considerable chemical inertness due to the strong covalent bonds of the carbon atoms on the nanotube surface.
Antônio Gomes de Souza Filho +1 more
doaj +1 more source
Quantum Chemical Methods for Modeling Covalent Modification of Biological Thiols [PDF]
, 2019 Targeted covalent inhibitor drugs require computational methods that go beyond simple molecular-mechanical force fields in order to model the chemical reactions that occur when they bind to their targets.
William, Isley +7 more
core +2 more sources
Advanced Engineering Materials, Volume 27, Issue 6, March 2025.ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur +5 more
wiley +1 more source