The kinetics of the reduction of the lipophilic quinone avarone by n-alkyl-1,4-dihydronicotinamides of various lipophilicities [PDF]
Journal of the Serbian Chemical Society, 1999 Several NADH model compounds, N-alkyl-1,4-dihydronicotinamides, some of them possessing amphiphilic properties, have been synthesized, and the kinetics of their reaction with a biologically active liphophilic quinone, avarone, has been studied in a ...
MIROSLAV J. GASIC +2 more
doaj +6 more sources
Synthesis and biological activity of amino acid derivatives of avarone and its model compound [PDF]
Bioorganic and Medicinal Chemistry, 2015 A series of eighteen derivatives of marine sesquiterpene quinone avarone and its model system tert-butylquinone with amino acids has been synthesized by nucleophilic addition of amino acids to the quinones. In vitro cytotoxic activity toward human cancer
Ivana Matic +2 more
exaly +7 more sources
Synthesis and Evaluation of Cytostatic and Antiviral Activities of 3′ and 4′-Avarone Derivatives
Antiviral Chemistry and Chemotherapy, 1991 A series of 3′ and 4′-substituted avarone derivatives were synthesized and tested in culture systems as antitumour and antiviral agents in comparison to avarol and avarone. 3′-alkylamino derivatives showed potent cytostatic activities against murine L1210 and human B (Raji) and T (C8166, H9) lymphoblast cells (ID50 range 1.7–3.7 μm).
Alessandra Pani +2 more
exaly +7 more sources
The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives [PDF]
FEBS Letters, 1990 We have analyzed the effects of several natural compounds related to avarols and avarones on the catalytic functions of human immunodeficiency virus type 1 (HIV‐1) reverse transcriptase (RT). The most potent substances, designated as avarone A,B and E and avarol F, inhibited indiscriminately the enzymatic activities of HIV‐1 RT, namely the RNA ...
A Hizi, S Loya
exaly +4 more sources
Pinocembrin Reduces Keratinocyte Activation and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in BALB/c Mice through the Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Pathway. [PDF]
Evid Based Complement Alternat Med, 2022 Psoriasis is an autoimmune disease characterized by chronic skin inflammation and excessive keratinocyte proliferation. The itchy, scaly, and erythematous lesions present on psoriatic skin negatively affect patients’ quality of life. Pinocembrin is a flavonoid present in propolis, fruits, and vegetables.
Huang KK +6 more
europepmc +2 more sources
Bird's eye view of natural products for the development of new anti-HIV agents: Understanding from a therapeutic viewpoint. [PDF]
Animal Model Exp MedDevelopment of pharmaceutical drugs to cure HIV is crucial due to the current widespread epidemic. Nucleosides are the most effective anti‐HIV drugs, but their high toxicity and drug resistance limit their use. This review focuses on potential natural medicinal products for treating and managing HIV and AIDS.
Al Amin M +12 more
europepmc +2 more sources
Simple avarone mimetics as selective agents against multidrug resistant cancer cells. [PDF]
European Journal of Medicinal Chemistry, 2016 In this work, synthesis of alkylamino and aralkylamino derivatives of sesquiterpene quinone avarone and its model compound tert-butylquinone was described. For all obtained derivatives biological activity was studied.
Marko Jeremić +6 more
semanticscholar +8 more sources
Natural Product Research, 2018 This study aimed to screen in vitro antitumour activity of the redox couple avarol/avarone against the human malignant glioma cell line U-251 MG for the first time.
B. Pejin +4 more
semanticscholar +4 more sources
Abstract 1303: Avarone and Hymenidin as potential inhibitors for Mycobacterium sp
Journal of Biological Chemistry, 2023 C. Stasiak +3 more
semanticscholar +2 more sources
Regioselectivity of conjugate additions to monoalkyl-1,4-benzoquinones [PDF]
Journal of the Serbian Chemical Society, 2002 The regioselectivity of the reaction of conjugate addition of thiols, amines, methanol and hydrogen chloride with the monoalkyl-1,4-benzoquinones avarone and 2-tert-butyl-1,4-benzoquinone was investigated.
SNEZANA TRIFUNOVIC +5 more
doaj +3 more sources