Results 11 to 20 of about 442 (142)

Simple avarone mimetics as selective agents against multidrug resistant cancer cells [PDF]

European Journal of Medicinal Chemistry, 2016
In this work, synthesis of alkylamino and aralkylamino derivatives of sesquiterpene quinone avarone and its model compound tert-butylquinone was described. For all obtained derivatives biological activity was studied. Cytotoxic activity of the synthesized derivatives towards multidrug resistant MDR human non-small cell lung carcinoma NCI-H460/R cells ...
Jeremić, Marko, Pešić, Milica, Dinić, Jelena, Banković, Jasna, Novaković, Irena, Šegan, Dejan, Sladić, Dušan   +6 more
core   +17 more sources

Bioconjugate of lysozyme and the antibacterial marine sesquiterpene quinone avarone and its derivatives. [PDF]

Bioconjug Chem, 2012
A conjugate of lysozyme with avarone, a bioactive sesquiterpene quinone of marine origin, and its three derivatives were synthesized. MALDI TOF mass spectral analysis and tryptic digestion showed that the only residue in lysozyme that was modified by all derivatives was lysine 97.
Novaković I, Anđelković U, Zlatović M, Gašić MJ, Sladić D.   +4 more
europepmc   +12 more sources

Traditional and Modern Biomedical Prospecting: Part II—The Benefits [PDF]

Evidence-Based Complementary and Alternative Medicine, Volume 1, Issue 2, Page 133-144, 2004., 2004
The progress in molecular and cell biology has enabled a rational exploitation of the natural resources of the secondary metabolites and biomaterials from sponges (phylum Porifera). It could be established that these natural substances are superior for biomedical application to those obtained by the traditional combinatorial chemical approach.
Werner E. G. Müller, Heinz C. Schröder, Matthias Wiens, Sanja Perovic-Ottstadt, Renato Batel, Isabel M. Müller   +5 more
wiley   +2 more sources

The Avarol-Avarone Redox Behaviour in Acetonitrile [PDF]

Croatica Chemica Acta, 1985
The oxidation of avarol and the reduction of avarone were studied at a Pt electrode in acetonitrile-tetraethyl-ammonium perchlorate media. The oxidation of avarol in acetonitrile takes place by formation of a two electron oxidation product, presumably the »protonated avarone«. The reduction of avarone takes place in two steps by formation of the stable
Gašić, Miroslav J., Sladić, Dušan, Tabaković, Ibro, Davidović, Asima   +3 more
openaire   +3 more sources

Natural Bioactive Compounds from Marine Invertebrates That Modulate Key Targets Implicated in the Onset of Type 2 Diabetes Mellitus (T2DM) and Its Complications. [PDF]

Pharmaceutics, 2023
Background: Type 2 diabetes mellitus (T2DM) is an ongoing, risky, and costly health problem that therefore always requires new treatment options. Moreover, although several drugs are available, only 36% of patients achieve glycaemic control, and patient ...
Casertano M, Vito A, Aiello A, Imperatore C, Menna M.   +4 more
europepmc   +3 more sources

Total Synthesis of Dactyloquinone A and Spiroetherone A via a Metal-Hydride Hydrogen Atom Transfer (MHAT) Process and a Quinol-Enedione Rearrangement. [PDF]

Angew Chem Int Ed Engl
Total syntheses of the meroterpenoid quinones dactyloquinone A and spiroetherone A were achieved from a common intermediate through the following original key steps: a metal‐hydride hydrogen atom transfer (MHAT) process with a quinone monoacetal in the case of dactyloquinone A, and a quinol–enedione rearrangement in the case of spiroetherone A ...
Schoenn G, Kouklovsky C, Guillot R, Magauer T, Vincent G.   +4 more
europepmc   +2 more sources

Pinocembrin Reduces Keratinocyte Activation and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in BALB/c Mice through the Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Pathway. [PDF]

Evid Based Complement Alternat Med, 2022
Psoriasis is an autoimmune disease characterized by chronic skin inflammation and excessive keratinocyte proliferation. The itchy, scaly, and erythematous lesions present on psoriatic skin negatively affect patients’ quality of life. Pinocembrin is a flavonoid present in propolis, fruits, and vegetables.
Huang KK, Lin MN, Hsu HC, Hsu YL, Huang TN, Lu IH, Pan IH.   +6 more
europepmc   +2 more sources

Bird's eye view of natural products for the development of new anti-HIV agents: Understanding from a therapeutic viewpoint. [PDF]

Animal Model Exp Med
Development of pharmaceutical drugs to cure HIV is crucial due to the current widespread epidemic. Nucleosides are the most effective anti‐HIV drugs, but their high toxicity and drug resistance limit their use. This review focuses on potential natural medicinal products for treating and managing HIV and AIDS.
Al Amin M, Nafady MH, Zehravi M, Sweilam SH, Kumar KP, Akiful Haque M, Unnisa A, Singh LP, Sayeed M, Alshehri MA, Ahmad I, Emran TB, Uddin MZ.   +12 more
europepmc   +2 more sources

Antiplasmodial activity of p-substituted benzyl thiazinoquinone derivatives and their potential against parasitic infections [PDF]

, 2020
Malaria is a life-threatening disease and, what is more, the resistance to available antimalarial drugs is a recurring problem. The resistance of Plasmodium falciparum malaria parasites to previous generations of medicines has undermined malaria control ...
Basilico, Nicoletta, Casertano, Marcello, Fattorusso, Caterina, Imperatore, Concetta, Menna, Marialuisa, Parapini, Silvia, Persico, Marco   +6 more
core   +2 more sources

Natural Products Derived from Marine Sponges with Antitumor Potential against Lung Cancer: A Systematic Review. [PDF]

Mar Drugs
Non-small-cell lung cancer (NSCLC), the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide, has been extensively investigated in the last decade in terms of developing new therapeutic options that increase patient ...
Ortigosa-Palomo A, Quiñonero F, Ortiz R, Sarabia F, Prados J, Melguizo C.   +5 more
europepmc   +3 more sources