Results 11 to 20 of about 194 (112)

The kinetics of the reduction of the lipophilic quinone avarone by n-alkyl-1,4-dihydronicotinamides of various lipophilicities [PDF]

Journal of the Serbian Chemical Society, 1999
Several NADH model compounds, N-alkyl-1,4-dihydronicotinamides, some of them possessing amphiphilic properties, have been synthesized, and the kinetics of their reaction with a biologically active liphophilic quinone, avarone, has been studied in a ...
MIROSLAV J. GASIC, DUSAN SLADIC, MARIO ZLATOVIC   +2 more
doaj   +5 more sources

Bioconjugate of lysozyme and the antibacterial marine sesquiterpene quinone avarone and its derivatives. [PDF]

Bioconjug Chem, 2012
A conjugate of lysozyme with avarone, a bioactive sesquiterpene quinone of marine origin, and its three derivatives were synthesized. MALDI TOF mass spectral analysis and tryptic digestion showed that the only residue in lysozyme that was modified by all derivatives was lysine 97.
Novaković I, Anđelković U, Zlatović M, Gašić MJ, Sladić D.   +4 more
europepmc   +7 more sources

Chemical modification of β-lactoglobulin by quinines [PDF]

Journal of the Serbian Chemical Society, 2003
The avarone/avarol quinone/hydroquinone couple, as well as their derivatives show considerable antitumor activity. In this work, covalent modifications of β-lactoglobulin, isolated from cow milk, by avarone, its model compound 2-tert-butyl-1,4 ...
Novaković Irena, Vujčić Zoran M., Božić Tatjana T., Božić Nataša M., Milosavić Nenad B., Sladić Dušan M.   +5 more
doaj   +1 more source

Protein covalent modification of biologically active quinones [PDF]

Journal of the Serbian Chemical Society, 2004
The avarone/avarol quinone/hydroquinone couple shows considerable antitumor activity. In this work, covalent modification of β-lactoglobulin by avarone and its derivatives as well as by the synthetic steroidal quinone 2,5(10)-estradiene- 1,4,17-trione ...
Sladić Dušan M., Novaković Irena, Vujčić Zoran M., Božić Tatjana T., Božić Nataša M., Milić Dragan, Šolaja Bogdan A., Gašić Miroslav J.   +7 more
doaj   +1 more source

Simple avarone mimetics as selective agents against multidrug resistant cancer cells [PDF]

European Journal of Medicinal Chemistry, 2016
In this work, synthesis of alkylamino and aralkylamino derivatives of sesquiterpene quinone avarone and its model compound tert-butylquinone was described. For all obtained derivatives biological activity was studied. Cytotoxic activity of the synthesized derivatives towards multidrug resistant MDR human non-small cell lung carcinoma NCI-H460/R cells ...
Jeremić, Marko, Pešić, Milica, Dinić, Jelena, Banković, Jasna, Novaković, Irena, Šegan, Dejan, Sladić, Dušan   +6 more
openaire   +13 more sources

Alkylamino and aralkylamino derivatives of avarone and its mimetic as selective agents against non-small cell lung cancer cells, their antibacterial and antifungal potential [PDF]

Journal of the Serbian Chemical Society, 2018
In this paper, the synthesis of fourteen alkylamino and arylamino derivatives of sesquiterpene quinone avarone and its model compound tert-butylquinone is described.
Jeremić Marko, Dinić Jelena, Pešić Milica, Stepanović Marija, Novaković Irena, Šegan Dejan, Sladić Dušan   +6 more
doaj   +1 more source

Marine metabolites for HIV control: A multi-target in-silico approach [PDF]

International Journal of Minor Fruits, Medicinal and Aromatic Plants
This study evaluates the potential of marine sponge-derived metabolites as multi-target inhibitors of Human Immunodeficiency Virus (HIV), aiming to overcome the limitations of current antiretroviral therapies.
Vivekananthan Govindaraj
doaj   +1 more source

Environmentally Friendly Antifouling Metabolites from Red Sea Organisms

Journal of Chemistry, Volume 2019, Issue 1, 2019., 2019
Seventy‐one marine organisms representing different classes of marine fauna and flora were collected from the Red Sea. They include sponges, hydrozoan, soft corals, sea cucumber, ascidian, cyanobacteria, and macroalgae. The methanolic extracts were evaluated for their toxicity and settlement inhibition effects by using cultured Balanus amphitrite ...
Sultan Semran Al-Lihaibi, Ahmed Abdel-Lateff, Walied Mohamed Alarif, Hajer Saeed Alorfi, Yasuyuki Nogata, Tatsufumi Okino, Mariana A. Reis   +6 more
wiley   +1 more source

Marine Invertebrate Natural Products for Anti‐Inflammatory and Chronic Diseases

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
The marine environment represents a relatively available source of functional ingredients that can be applied to various aspects of food processing, storage, and fortification. Moreover, numerous marine invertebrates based compounds have biological activities and also interfere with the pathogenesis of diseases.
Kalimuthu Senthilkumar, Se-Kwon Kim, Edwin L. Cooper   +2 more
wiley   +1 more source

Traditional and Modern Biomedical Prospecting: Part II—The Benefits

Evidence-Based Complementary and Alternative Medicine, Volume 1, Issue 2, Page 133-144, 2004., 2004
The progress in molecular and cell biology has enabled a rational exploitation of the natural resources of the secondary metabolites and biomaterials from sponges (phylum Porifera). It could be established that these natural substances are superior for biomedical application to those obtained by the traditional combinatorial chemical approach.
Werner E. G. Müller, Heinz C. Schröder, Matthias Wiens, Sanja Perovic-Ottstadt, Renato Batel, Isabel M. Müller   +5 more
wiley   +1 more source