Results 211 to 220 of about 140,209 (263)

Model‐Enabled Knowledge Transfer Across Cell Lines, Culture Scales and Conditions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Mechanistic models are central to quantitative understanding and optimization of Chinese hamster ovary (CHO) cell culture processes, but their utility is often restricted by parameter sets calibrated for specific cell lines, scales, or operating conditions.
Luxi Yu, Antonio del Rio Chanona, Cleo Kontoravdi   +2 more
wiley   +1 more source

LLM‐Guided Parameter Optimization for Mechanistic CHO Cell Bioreactor Models

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Mechanistic models of Chinese Hamster Ovary (CHO) cell cultures are essential for efficient bioprocess development and control, yet parameter estimation remains a critical challenge in model calibration. As model complexity increases, the number of parameters grows and their values become highly system‐specific due to biological variability ...
Han Bit Kim, Janghan Lee, Seo‐Yeon Kim, Jihoon Kim, Moo Sun Hong   +4 more
wiley   +1 more source

Machine Learning‐Based PAT Tool for Real‐Time Residual Moisture Monitoring in Lyophilized Biopharmaceuticals Using NIR Spectroscopy

Biotechnology and Bioengineering, EarlyView.
ABSTRACT There is a growing demand in the pharmaceutical industry to optimize analytical methodologies, reducing time and resource consumption while ensuring rapid process development and cost‐efficient manufacturing. Indeed, Food and Drug Administration (FDA) introduced the Process Analytical Technology (PAT) as an initiative enabling manufacturers to
Samuele Fiorenza, Mariapia D'Urso, Ambra Massei, Nunzia Falco, Davide Fissore, Enza Torino   +5 more
wiley   +1 more source

Advances in causal discovery methods for ecological time series

Biological Reviews, EarlyView.
ABSTRACT Recent advances in data collection technologies (e.g. automated sensor networks, satellite remote sensing, and high‐throughput sequencing) have greatly expanded the availability of ecological time series, enabling new opportunities for causal analyses in dynamic ecosystems.
Kenta Suzuki, Masato Yamamichi, Yutaka Osada, Masayuki Ushio, Kohei Nakajima, Hiroshi Masuya, Shohei Shimizu   +6 more
wiley   +1 more source

Dynamics of biotic resistance to plant invasions

Biological Reviews, EarlyView.
ABSTRACT Biotic resistance, the reduction in invasion success caused by native communities, plays an important role in the long‐term dynamics of biological invasions. A large body of empirical research on biotic resistance has accumulated since the last comprehensive review on the subject 20 years ago, enabling us to achieve a refined understanding of ...
Christine S. Sheppard, Joshua I. Brian, Wayne Dawson, Petr Dostál, Franz Essl, Michal Gruntman, Tina Heger, Mark van Kleunen, Mialy Razanajatovo, Lena C. Reimann, Frank M. Schurr, Montserrat Vilà, Florencia A. Yannelli, Marina Golivets   +13 more
wiley   +1 more source

Evidence for adaptive explanations of semelparity in animals

Biological Reviews, EarlyView.
ABSTRACT Semelparity, the reproductive strategy of reproducing once, is widespread but uncommon in animals. Classes of models to explain the evolution of semelparity are based either on age structure and mortality schedules – demographic models in which high post‐reproductive mortality risk favours high reproductive effort and semelparity results from ...
Diana O. Fisher, Roberto Salguero‐Gómez   +1 more
wiley   +1 more source

Green Is the New Gold: Redefining Opulent Lifestyle Through Organic Food Purchases

Business Strategy and the Environment, EarlyView.
ABSTRACT Prior studies based on the Theory of Planned Behavior mostly examined the effects of health and environmental concerns on organic food consumption; however, few addressed the paradoxical relationships in the context of opulent or symbolic decorum.
Neha Sharma, Swati Singh, Agnieszka Kabalska, Ralf Wagner   +3 more
wiley   +1 more source

Exploring the Governance–Disclosure Nexus: Board Structures and ESG Disclosures in South Africa

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how governance structures such as board composition and board functions influence environmental, social and governance (ESG) reporting among listed South African firms. This study examines 90 public listed companies on the Johannesburg Stock Exchange between 2012 and 2022.
Henriette Elsabe Scholtz, Suzanne Kieviet   +1 more
wiley   +1 more source

Organising for Circularity: An Empirical Analysis of Project Organising and the Development of Circular Economy Firm Capabilities

Business Strategy and the Environment, EarlyView.
ABSTRACT Firms pursue the circular economy (CE) by using projects as organisational forms. However, the transformative role of project organising (PO) in developing circular firm capabilities (FC) remains underexplored. In this study, we examine the effects of PO on the development of critical circular FC in CE‐based firms. We draw on primary data from
Ambisisi Ambituuni, Hakeem Sunmola, Emmanouil Tyllianakis, Oluwaseun Kolade, Soroush Abolfathi, Muyiwa Oyinlola   +5 more
wiley   +1 more source

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The Covariance Matrix of the Information Matrix Test

Econometrica, 1984
In this note we point out how the covariance matrix of the information matrix test, due to \textit{H. White} [ibid. 50, 1-25 (1982; Zbl 0478.62088)], can be estimated without the computation of analytic third derivatives of the density function.
openaire   +2 more sources