Results 51 to 60 of about 309,621 (292)

Nonparametric goodness‐of‐fit testing for parametric covariate models in pharmacometric analyses

CPT: Pharmacometrics & Systems Pharmacology, 2021
The characterization of covariate effects on model parameters is a crucial step during pharmacokinetic/pharmacodynamic analyses. Although covariate selection criteria have been studied extensively, the choice of the functional relationship between ...
Niklas Hartung, Martin Wahl, Abhishake Rastogi, Wilhelm Huisinga   +3 more
doaj   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Randomization Tests that Condition on Non-Categorical Covariate Balance

Journal of Causal Inference, 2019
A benefit of randomized experiments is that covariate distributions of treatment and control groups are balanced on average, resulting in simple unbiased estimators for treatment effects.
Branson Zach, Miratrix Luke W.
doaj   +1 more source

Effect of neighborhood and plot size on experiments with multiple-harvest oleraceous crops

Pesquisa Agropecuária Brasileira, 2014
The objective of this work was to determine the efficiency of the Papadakis method on the quality evaluation of experiments with multiple-harvest oleraceous crops, and on the estimate of the covariate and the ideal plot size.
Daniel Santos, Alessandro Dal'Col Lúcio, Alberto Cargnelutti Filho, Lindolfo Storck, Leandro Homrich Lorentz, Denison Esequiel Schabarum   +5 more
doaj   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Identifying key covariates of clinical outcomes for critically ill patients with Parkinson’s disease: analysis of the MIMIC-IV database

Frontiers in Neurology
BackgroundParkinson’s disease (PD) is a common chronic degenerative disease, and its exact pathological mechanism remains unclear. In this study, we identified covariates associated with the clinical outcomes of PD using patient data from the Medical ...
LiHua Luo, Yang Chen, HangQing Zhao, HangQing Zhao, Rong Dong, Rong Dong, Yuzhou Long   +6 more
doaj   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

Covariate Adjusted ROC Curve Analysis and An Application

Sakarya Tıp Dergisi, 2015
Objective: Aim of this study is to analyze the change of the area under the adjusted ROC (AdjROC) curve in certain conditions via binormal distribution model using simulation studies and application of this algorithm to real data.
Cengiz Bal, Ertuğrul Çolak, Hasan Ekerbiçer, İlker Etikan, Kazım Özdamar, Ünal Erkorkmaz   +5 more
doaj  

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

Covariant hyperquantization

, 1956
The differential equations for the vacuum expectation values of chronological products of field operators are transcribed into an operator formalism which is covariant under the Lorentz group. This is accomplished by introducing a new set of field operators with the same transformation properties as the ordinary fields to which they correspond.
openaire   +2 more sources