Results 121 to 130 of about 838,163 (294)
CPT: Pharmacometrics & Systems PharmacologyLinerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the ...
Fernando Carreño +4 more
doaj +1 more source
, 1956 The differential equations for the vacuum expectation values of chronological products of field operators are transcribed into an operator formalism which is covariant under the Lorentz group. This is accomplished by introducing a new set of field operators with the same transformation properties as the ordinary fields to which they correspond.
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Spatio-Temporal Count Autoregression
Data Science in ScienceWe study the problem of modeling and inference for spatio-temporal count processes. Our approach uses parsimonious parameterisations of multivariate autoregressive count time series models, including possible regression on covariates.
Steffen Maletz +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes +75 more
wiley +1 more source
Compound Optimum Designs for Clinical Trials in Personalized Medicine
MathematicsWe consider optimal designs for clinical trials when response variance depends on treatment and covariates are included in the response model. These designs are generalizations of Neyman allocation, and commonly employed in personalized medicine where ...
Belmiro P. M. Duarte +3 more
doaj +1 more source
Classification of covariates and relationship between covariates, exposure and outcome.
Classification of covariates and relationship between covariates, exposure and outcome.
Keely Cheslack-Postava (242557) +5 more
core +1 more source
Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song +10 more
wiley +1 more source