Results 1 to 10 of about 8,781 (113)
Population Pharmacokinetics of Primaquine in the Korean Population [PDF]
Pharmaceutics, 2021 While primaquine has long been used for malaria treatment, treatment failure is common. This study aims to develop a population pharmacokinetic model of primaquine and its metabolite, carboxyprimaquine, and examine factors influencing pharmacokinetic variability.
Woo-Yul Lee +6 more
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Pharmacokinetics and population pharmacokinetics in pediatric oncology [PDF]
Pediatric Blood & Cancer, 2019 AbstractPharmacokinetic research has become increasingly important in pediatric oncology as it can have direct clinical implications and is a crucial component in individualized medicine. Population pharmacokinetics has become a popular method especially in children, due to the potential for sparse sampling, flexible sampling times, computing of ...
Sebastiaan D.T. Sassen +3 more
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Population pharmacokinetics of pomalidomide [PDF]
The Journal of Clinical Pharmacology, 2015 AbstractA population pharmacokinetic (PPK) model of pomalidomide was developed and the influence of demographic and disease‐related covariates on PPK parameters was assessed based on data from 6 clinical trials of pomalidomide (dose range, 0.5–10 mg) in healthy participants (n = 96) and patients with multiple myeloma (MM; n = 144).
Li, Yan +5 more
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Population pharmacokinetics of exenatide [PDF]
British Journal of Clinical Pharmacology, 2016 AimThe aim of the present analysis was to develop a core population pharmacokinetic model for the pharmacokinetic properties of immediate‐release (IR) exenatide, which can be used in subsequent analyses of novel sustained‐release formulations.MethodsData from eight clinical trials, evaluating a wide range of doses and different administration routes ...
Cirincione, Brenda, Mager, Donald E.
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Population Pharmacokinetics of Daptomycin [PDF]
Antimicrobial Agents and Chemotherapy, 2004 ABSTRACT Data from subjects in nine phase 1 ( n = 153) and six phase 2/3 ( n = 129) clinical trials were combined to identify factors contributing to interindividual variability in daptomycin pharmacokinetics (PK). Over 30 covariates were considered.
Barry, Dvorchik +5 more
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Population Pharmacokinetics of Teicoplanin in Children [PDF]
Antimicrobial Agents and Chemotherapy, 2014 ABSTRACT Teicoplanin is frequently administered to treat Gram-positive infections in pediatric patients. However, not enough is known about the pharmacokinetics (PK) of teicoplanin in children to justify the optimal dosing regimen.
Ramos-Martin V. +14 more
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Population Pharmacokinetics and CD20 Binding Dynamics for Mosunetuzumab in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (R/R NHL) [PDF]
, 2023 Brendan C. Bender +13 more
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Population pharmacokinetics: an overview
Australian Prescriber, 2014 The pharmacokinetics of a drug refers to how it is handled by the body. This includes absorption, distribution, metabolism and elimination.
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Application of population pharmacokinetics to cladribine [PDF]
BMC Pharmacology, 2005 Abstract Background The nucleoside analog cladribine is used for the treatment of a variety of indolent B- and T-cell lymphoid malignancies. The primary aim of the study was to evaluate the population distribution of pharmacokinetic parameters in patients undergoing treatment with cladribine and to detect
Lindemalm, Synnöve +5 more
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Tobramycin population pharmacokinetics in neonates* [PDF]
Clinical Pharmacology & Therapeutics, 1997 To establish a tobramycin dosing schedule for neonates of various gestational ages.This was a retrospective study with prospective validation. A retrospective study in 470 neonates, with suspected septicemia in the first week of life, was performed. All patients received tobramycin according to the following scheme: neonates with a gestational age of ...
de Hoog, Matthijs +3 more
openaire +3 more sources