Results 1 to 10 of about 112,978 (213)
Population Pharmacokinetics of the Novel Myeloperoxidase Inhibitor Mitiperstat [PDF]
Pharmacology Research & PerspectivesMitiperstat is a novel myeloperoxidase inhibitor being investigated for the treatment of heart failure, metabolic dysfunction‐associated steatohepatitis, and chronic obstructive pulmonary disease.
Mikael Sunnåker +2 more
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Population pharmacokinetics of DNDI-6148 in healthy adults. [PDF]
PLoS Neglected Tropical DiseasesLeishmaniasis (both visceral and cutaneous) and Chagas disease (CD) are among the most neglected tropical diseases, with limited treatment options and an urgent need for safer, more effective therapies.
Frauke Assmus +9 more
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Population pharmacokinetics analysis in Lixoft Monolix softwares
Фармакокинетика и Фармакодинамика, 2022 The article has discussed a step-by-step algorithm for developing population pharmacokinetics models in the Lixoft Monolix software. Features of population pharmacokinetics study’s methodology have described.
A. I. Platova
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Population Pharmacokinetics of Primaquine in the Korean Population
Pharmaceutics, 2021 While primaquine has long been used for malaria treatment, treatment failure is common. This study aims to develop a population pharmacokinetic model of primaquine and its metabolite, carboxyprimaquine, and examine factors influencing pharmacokinetic ...
Woo-Yul Lee +6 more
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Pharmaceuticals, 2021 Understanding the pharmacokinetics parameter of colistin methanesulfonate sodium (CMS) and colistin is needed to optimize the dosage regimen in critically ill patients. However, there is a scarcity of pharmacokinetics parameters in this population.
Mohd Shafie Zabidi +4 more
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Review on Population Pharmacokinetics of Amikacin in Paediatrics
Journal of Pure and Applied Microbiology, 2022 Amikacin is an aminoglycoside antibiotic with a broad-spectrum bacterial coverage that is frequently utilized both as monotherapy and in combination with other antibiotics for severe bacterial infections in the paediatric population.
Keerthana Chandrasekar +4 more
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Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures [PDF]
Korean Journal of Pediatrics, 2017 PurposeThe aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM.MethodsA retrospective analysis of 18 ...
Jae Won Shin +7 more
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Genetic Parameter Estimates for Metabolizing Two Common Pharmaceuticals in Swine
Frontiers in Genetics, 2018 In livestock, the regulation of drugs used to treat livestock has received increased attention and it is currently unknown how much of the phenotypic variation in drug metabolism is due to the genetics of an animal.
Jeremy T. Howard +5 more
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Population Pharmacokinetics of Lithium in Young Pediatric Patients With Intellectual Disability
Frontiers in Pharmacology, 2021 Background: Lithium is a well-established treatment for bipolar disorders and has been shown to be neuroprotective, and thus low doses might be useful for the treatment of childhood brain injury and neurological sequelae.
Junying Yuan +16 more
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Pharmaceutics, 2022 Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic insight into biological ...
Lina Keutzer +11 more
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