Results 21 to 30 of about 5,090,795 (152)

Population Pharmacokinetics and Dosage Optimization of Teicoplanin in Children With Different Renal Functions

Frontiers in Pharmacology, 2020
ObjectiveThe purposes of our study were to investigate the population pharmacokinetics of teicoplanin in Chinese children with different renal functions and to propose the appropriate dosing regimen for these pediatric patients.MethodsWe performed a ...
Liuliu Gao, Hua Xu, Qi Ye, Sichan Li, Jun Wang, Yan Mei, Changhe Niu, Ting Kang, Chen Chen, Yang Wang   +9 more
doaj   +1 more source

Is a Lower Dose of Rivaroxaban Required for Asians? A Systematic Review of a Population Pharmacokinetics and Pharmacodynamics Analysis of Rivaroxaban

Pharmaceutics, 2023
Rivaroxaban has been widely used to prevent and treat various thromboembolic diseases for more than a decade. However, whether a lower dose of rivaroxaban is required for Asians is still debatable.
Xiao-Qin Liu, Zi-Ran Li, Chen-Yu Wang, Yue-Ting Chen, Zheng Jiao   +4 more
doaj   +1 more source

Population Pharmacokinetics of Vancomycin in Pregnant Women

Frontiers in Pharmacology, 2022
Objective: Vancomycin is a glycopeptide antibacterial indicated for serious gram-positive infections. Pharmacokinetics (PK) of vancomycin have not been described in pregnant women.
Rahul K. Goyal, Brady S. Moffett, Brady S. Moffett, Jogarao V. S. Gobburu, Mayar Al Mohajer   +4 more
doaj   +1 more source

Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-group Prospective Cohort Study in two sub-Saharan Africa Populations. [PDF]

, 2013
We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two African populations. ART naïve HIV patients from Ethiopia (n = 285) and Tanzania (n = 209)
Makonnen, Eyasu, Ngaimisi, E, Klaus-Dieter Riedel, Habtewold, A, Burhenne Juergen, Mugusi, F, Mugusi Sabina, Janabi, M, Omary Minzi, Mugusi Ferdinand, Getachew Aderaye, Makonnen, E, Mohammed Janabi, Yimer Getnet, Yimer, G, Eleni Aklillu, Habtewold Abiy, Minzi Omary, Minzi, O, Mugusi, S, Riedel Klaus-Dieter, Ngaimisi Eliford, Aderaye, G, Ferdinand Mugusi, Mugusi, Ferdinand, Abiy Habtewold, Habtewold, A., Aklillu Eleni, Wondwossen Amogne, Amogne, W, Ngaimisi, E.,, Ngaimisi, Eliford, Amogne Wondwossen, Aderaye, Getachew, Minzi, Omary, Aderaye Getachew, Bertilsso, L, Makonnen Eyasu, Habtewold, Abiy, Riedel, K, Eliford Ngaimisi, Bertilsson, Leif, Mugusi, Sabina, Amogne, W., Riedel, Klaus-Dieter, Makonnen, E., Juergen Burhenne, Yimer, Getnet, Aklillu, E, Amogne, Wondwossen, Bertilsson Leif, Burhenne, J, Leif Bertilsson, Eyasu Makonnen, Burhenne, Juergen, Mugusi, S., Janabi, Mohammed, Aklillu, Eleni, Janabi Mohammed, Bertilsson, L, Sabina Mugusi, Getnet Yimer, Minzi, O.   +62 more
core   +2 more sources

Population pharmacokinetics and pharmacokinetic-pharmacodyamic modeling of antitubercular drugs [PDF]

, 2013
Includes abstract.Includes bibliographical references.The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in 78 patients with tuberculosis were described using non-linear mixed effects modeling.
Chigutsa, Emmanuel
core   +1 more source

DOXYCYCLINE PHARMACOKINETICS IN MAMMALIAN SPECIES OF VETERINARY INTEREST – AN OVERVIEW

Bulgarian Journal of Veterinary Medicine, 2022
Doxycycline is a broad-spectrum tetracycline antibiotic widely used in veterinary medicine. The current review aims to summarise the available data about pharmacokinetics in mammalian species of veterinary interest and to indicate the basic strategies ...
R. Mileva, A. Milanova
doaj   +1 more source

PKPy: a Python-based framework for automated population pharmacokinetic analysis [PDF]

PeerJ
We present PKPy, an open-source Python framework designed to automate population pharmacokinetic analysis workflows. The framework emphasizes user accessibility by minimizing the need for manual parameter initialization while maintaining analytical rigor.
Hyunseung Kong, Inyoung Kim, Byoung-Tak Zhang   +2 more
doaj   +2 more sources

Impact of obesity on cefazolin pharmacokinetics and optimal dosing for surgical prophylaxis in patients with obesity

Clinical Infection in Practice
Cefazolin, a first-generation cephalosporin, has been used for decades for surgical site infection prophylaxis as well as for treatment for a variety of infections. Little data is available on dosing in obese individuals or those weighing ≥120 kg.
M. Courtney Safir, Michael Trang, Diana Valencia, Christopher R. Curtin, Christopher M. Rubino   +4 more
doaj   +1 more source

The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients

Balkan Journal of Medical Genetics, 2016
The aim of the present study was to investigate the distribution of CYP2C8 variants *3 and *5, as well as their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients on carbamazepine treatment.
Milovanovic DD, Milovanovic JR, Radovanovic M, Radosavljevic I, Obradovic S, Jankovic S, Milovanovic D, Djordjevic N   +7 more
doaj   +1 more source

Pharmacokinetic Models of Tafenoquine: Insights for Optimal Malaria Treatment Strategies

Pharmaceutics
Tafenoquine (TQ) is a new 8-aminoquinoline antimalarial drug developed by the US Army for Plasmodium vivax malaria treatment. Modeling and simulation are essential tools for drug development and improving rationality in pharmacotherapy, and different ...
Luisa Oliveira Santos, Izabel Almeida Alves, Francine Johansson Azeredo   +2 more
doaj   +1 more source