Results 21 to 30 of about 114,024 (159)

Is a Lower Dose of Rivaroxaban Required for Asians? A Systematic Review of a Population Pharmacokinetics and Pharmacodynamics Analysis of Rivaroxaban

Pharmaceutics, 2023
Rivaroxaban has been widely used to prevent and treat various thromboembolic diseases for more than a decade. However, whether a lower dose of rivaroxaban is required for Asians is still debatable.
Xiao-Qin Liu, Zi-Ran Li, Chen-Yu Wang, Yue-Ting Chen, Zheng Jiao   +4 more
doaj   +1 more source

Population Pharmacokinetics and Dosage Optimization of Teicoplanin in Children With Different Renal Functions

Frontiers in Pharmacology, 2020
ObjectiveThe purposes of our study were to investigate the population pharmacokinetics of teicoplanin in Chinese children with different renal functions and to propose the appropriate dosing regimen for these pediatric patients.MethodsWe performed a ...
Liuliu Gao, Hua Xu, Qi Ye, Sichan Li, Jun Wang, Yan Mei, Changhe Niu, Ting Kang, Chen Chen, Yang Wang   +9 more
doaj   +1 more source

Population Pharmacokinetics of Vancomycin in Pregnant Women

Frontiers in Pharmacology, 2022
Objective: Vancomycin is a glycopeptide antibacterial indicated for serious gram-positive infections. Pharmacokinetics (PK) of vancomycin have not been described in pregnant women.
Rahul K. Goyal, Brady S. Moffett, Brady S. Moffett, Jogarao V. S. Gobburu, Mayar Al Mohajer   +4 more
doaj   +1 more source

DOXYCYCLINE PHARMACOKINETICS IN MAMMALIAN SPECIES OF VETERINARY INTEREST – AN OVERVIEW

Bulgarian Journal of Veterinary Medicine, 2022
Doxycycline is a broad-spectrum tetracycline antibiotic widely used in veterinary medicine. The current review aims to summarise the available data about pharmacokinetics in mammalian species of veterinary interest and to indicate the basic strategies ...
R. Mileva, A. Milanova
doaj   +1 more source

PKPy: a Python-based framework for automated population pharmacokinetic analysis [PDF]

PeerJ
We present PKPy, an open-source Python framework designed to automate population pharmacokinetic analysis workflows. The framework emphasizes user accessibility by minimizing the need for manual parameter initialization while maintaining analytical rigor.
Hyunseung Kong, Inyoung Kim, Byoung-Tak Zhang   +2 more
doaj   +2 more sources

The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients

Balkan Journal of Medical Genetics, 2016
The aim of the present study was to investigate the distribution of CYP2C8 variants *3 and *5, as well as their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients on carbamazepine treatment.
Milovanovic DD, Milovanovic JR, Radovanovic M, Radosavljevic I, Obradovic S, Jankovic S, Milovanovic D, Djordjevic N   +7 more
doaj   +1 more source

Pharmacokinetic Models of Tafenoquine: Insights for Optimal Malaria Treatment Strategies

Pharmaceutics
Tafenoquine (TQ) is a new 8-aminoquinoline antimalarial drug developed by the US Army for Plasmodium vivax malaria treatment. Modeling and simulation are essential tools for drug development and improving rationality in pharmacotherapy, and different ...
Luisa Oliveira Santos, Izabel Almeida Alves, Francine Johansson Azeredo   +2 more
doaj   +1 more source

Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution

Chinese Medical Journal, 2015
Background: High-dose methotrexate (HD-MTX) with folinic acid (leucovorin) rescue is the gold standard therapy in the treatment of osteosarcoma. The plasma concentration of MTX is closely related to efficacy and toxicity.
Wei Zhang, Qing Zhang, Xiaohuang Tian, Haitao Zhao, Wei Lu, Jiancun Zhen, Xiaohui Niu   +6 more
doaj   +1 more source

Population Pharmacokinetics and Dosing Optimization of Vancomycin in Pediatric Liver Transplant Recipients

Microbiology Spectrum, 2021
Methicillin-resistant Staphylococcus aureus infections are a significant cause of morbidity and mortality in pediatric liver transplant (LT) recipients.
Kensuke Shoji, Jumpei Saito, Hidenori Nakagawa, Takanori Funaki, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Jeremiah D. Momper, Edmund V. Capparelli, Isao Miyairi   +9 more
doaj   +1 more source

Enrofloxacin Dose Optimization for the Treatment of Colibacillosis in Broiler Chickens Using a Drinking Behaviour Pharmacokinetic Model

Antibiotics, 2021
Enrofloxacin is frequently administered via drinking water for the treatment of colibacillosis in broiler chickens. However, the EMA/CVMP has urged to re-evaluate historically approved doses, especially for antimicrobials administered via drinking water.
Robin Temmerman, Ludovic Pelligand, Wim Schelstraete, Gunther Antonissen, An Garmyn, Mathias Devreese   +5 more
doaj   +1 more source