Results 11 to 20 of about 5,090,795 (152)

Population pharmacokinetics of olprinone in healthy male volunteers

Clinical Pharmacology: Advances and Applications, 2014
Takayuki Kunisawa,1 Hidefumi Kasai,2 Makoto Suda,2 Manabu Yoshimura,3 Ami Sugawara,3 Yuki Izumi,3 Takafumi Iida,3 Atsushi Kurosawa,3 Hiroshi Iwasaki3 1Surgical Operation Department, Asahikawa Medical University Hospital, Hokkaido, Japan; 2Clinical Study ...
Kunisawa T, Kasai H, Suda M, Yoshimura M, Sugawara A, Izumi Y, Iida T, Kurosawa A, Iwasaki H   +8 more
doaj   +1 more source

Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients : a study by the EORTC-PAMM-NDDG

, 2007
Aims: To investigate the population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients. Patients and methods: Sixty-five female patients with early or advanced breast cancer received doxorubicin 60 mg/m(2)
Vermorken, Jan B, Schellens, Jan H M, Huitema, Alwin D R, Sorio, Roberto, Joerger, Markus, Twelves, Chris, Féty, Régine, Sleeboom, Henk P, Karlsson, Mats,, Dittrich, Christian, Pavlidis, Nikolas, Strocchi, Elena, Martoni, Andrea, Izquierdo, Miguel A, de Bruijn, Ernst, Richel, Dick J, Briasoulis, Evangelos, Schrijvers, Ad H G J, Tranchand, Brigitte, Beijnen, Jos H, Hempel, Georg, Jodrell, Duncan I   +21 more
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Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine During Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania. [PDF]

, 2010
The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine has been associated with the probability of adequate clinical and ...
Färnert, Anna, Zul Premji, Mårtensson, A, Annerberg, A, Mårtensson, Andreas, Annerberg, A., Andreas Mårtensson, Martensson, A., Bjorkman, A., Ngasala, B., Lindegårdh, N, Hietala, Sofia Friberg, Ngasala, B, Ashton, M., Dahlström, S, Gil, P, Friberg Hietala, Sofia,, Björkman, A, Premji, Z., Björkman, Anders, Sofia Friberg Hietala, Premji, Zul, Farnert, A., Dahlström, Sabina, Hietala, SF, Anna Annerberg, Annerberg, Anna, Anders Björkman, Anna Färnert, Pedro Gil, Lindegårdh, Niklas, Ashton, M, Ngasala, Billy, Michael Ashton, Färnert, A, Niklas Lindegårdh, Dahlstrom, S., Gil, P., Billy Ngasala, Lindegardh, N., Ashton, Michael, Gil, J. P., Premji, Z, Gil, Pedro, Hietala, S.F., Ashton, Michael,, Sabina Dahlström   +46 more
core   +1 more source

Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients [PDF]

, 2006
Background: Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible.
Mwenechanya, J, McIlleron Helen, Agbenyega, Tsiri, Molyneux, M, Olliaro, P, Miller, Raymond, Kyaw Win, Nosten Francois, Simpson, Julie A., Tembo, M, Simpson, Julie A, Ribeiro, Isabela, van Vugt, Michele, Weerasuriya, Kris, Molyneux Malcolm, Nicholas J White, Miller Raymond, Julie A Simpson, Pang, L, Pang, Lorrin, Gianni Di Perri, Simpson Julie A, White, Nicholas J., McIlleron, H, Francois Nosten, Mansor, Sharif, Perri, Gianni Di, Ward, Steve, Michele van Vugt, White, Nicholas J, Helen McIlleron, Ward Steve, Isabela Ribeiro, Sharif Mansor, Olliaro Piero, White Nicholas J, Simpson, JA, Perri, GD, Di Perri, Gianni, Di Perri, G, Piero Olliaro, Barnes, Karen I, Krudsood, S, Krishna, Sanjeev, Win, K, Navaratnam, Visweswaran, Barnes Karen I, White, NJ, van Vugt, M, Ward, S, Olliaro, Piero, Visweswaran Navaratnam, Navaratnam Visweswaran, Raymond Miller, James Mwenechanya, Molyneux, Malcolm, Sornchai Looareesuwan, Agbenyega, T, Krudsood, Srivicha, Agbenyega Tsiri, Folb, P, Mansor, S, Looareesuwan, S, van Vugt Michele, Looareesuwan, Sornchai, Perri Gianni Di, Tembo Madalitso, Lorrin Pang, Krudsood Srivicha, Gomes, M, Melba Gomes, Sanjeev Krishna, Julie A Simpson, Gomes, Melba, Win Kyaw, Navaratnam, V, Mansor Sharif, White, Nicholas, Folb Peter, Ribeiro Isabela, Madalitso Tembo, McIlleron, Helen, Weerasuriya Kris, Barnes, KI, Kris Weerasuriya, Pang Lorrin, Tembo, Madalitso, Folb, Peter, Malcolm Molyneux, Ribeiro, I, Srivicha Krudsood, Barnes, Karen I., Looareesuwan Sornchai, Mwenechanya, James, Gomes Melba, Krishna Sanjeev, Nosten, F, Tsiri Agbenyega, Karen I Barnes, Mwenechanya James, Steve Ward, Krishna, S, Peter Folb, Win, Kyaw, Weerasuriya, K, Miller, R, Nosten, Francois   +106 more
core   +2 more sources

The effects of pharmacogenetics on pharmacokinetics of artemisinin-based combinations in malaria patients [PDF]

, 2009
Malaria is a vector-borne infectious disease caused by protozoan parasites of the genus Plasmodium. If not treated appropriately, human P. falciparum malaria can quickly become life-threatening, leading to an estimated 900’000 annual deaths globally. Key
Hodel, Eva Maria
core   +1 more source

Physiologically Based Pharmacokinetics Modeling in the Neonatal Population—Current Advances, Challenges, and Opportunities

, 2023
Physiologically based pharmacokinetic (PBPK) modeling is an approach to predicting drug pharmacokinetics, using knowledge of the human physiology involved and drug physiochemical properties.
Trevor N. Johnson, Tamorah Lewis, Jean Dinh, Manuela Grimstein   +3 more
core   +1 more source

Gene co-expression network analysis identifies porcine genes associated with variation in metabolizing fenbendazole and flunixin meglumine in the liver

Scientific Reports, 2017
Identifying individual genetic variation in drug metabolism pathways is of importance not only in livestock, but also in humans in order to provide the ultimate goal of giving the right drug at the right dose at the right time.
Jeremy T. Howard, Melissa S. Ashwell, Ronald E. Baynes, James D. Brooks, James L. Yeatts, Christian Maltecca   +5 more
doaj   +1 more source

Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin

Pharmaceutics, 2022
Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic insight into biological ...
Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G. Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M. Svensson, Michael P. Menden, Ulrika S. H. Simonsson, on behalf of the UNITE4TB Consortium   +11 more
doaj   +1 more source

Modeling Approach to Optimizing Dose Regimen of Vancomycin for Chinese Pediatric Patients with Gram-Positive Bacterial Infections

Frontiers in Pharmacology, 2021
The aim of this study was to establish the population pharmacokinetics (PK) model of Vancomycin for Chinese pediatric patients which can extrapolate to whole age periods by bridging the published adult population PK model and the established pediatric ...
Kai Shen, Yaxin Fan, Minjie Yang, Yuancheng Chen, Jinhao Tao, Guoping Lu, Hong Zhang, Qiwei Huang, Jing Zhang   +8 more
doaj   +1 more source

Population Pharmacokinetics of CC-122

Clinical Pharmacology: Advances and Applications, 2021
Yiming Cheng,1 Jian Chen,2 Michael Pourdehnad,3 Simon Zhou,1 Yan Li1 1Clinical Pharmacology & Pharmacometrics, Bristol Myers Squibb, Summit, NJ, USA; 2Non-Clinical Research & Development, Bristol Myers Squibb, Summit, NJ, USA; 3Early Clinical ...
Cheng Y, Chen J, Pourdehnad M, Zhou S, Li Y   +4 more
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