Results 11 to 20 of about 114,024 (159)

Population Pharmacokinetics of the Novel Myeloperoxidase Inhibitor Mitiperstat [PDF]

Pharmacology Research & Perspectives
Mitiperstat is a novel myeloperoxidase inhibitor being investigated for the treatment of heart failure, metabolic dysfunction‐associated steatohepatitis, and chronic obstructive pulmonary disease.
Mikael Sunnåker, Jacob Leander, Hans Ericsson   +2 more
doaj   +2 more sources

Population pharmacokinetics of DNDI-6148 in healthy adults. [PDF]

PLoS Neglected Tropical Diseases
Leishmaniasis (both visceral and cutaneous) and Chagas disease (CD) are among the most neglected tropical diseases, with limited treatment options and an urgent need for safer, more effective therapies.
Frauke Assmus, Ayorinde Adehin, Richard M Hoglund, Charles E Mowbray, Jean-Yves Gillon, Séverine Blesson, Stéphanie Braillard, Eric Chatelain, Ivan Scandale, Joel Tarning   +9 more
doaj   +2 more sources

Population Pharmacokinetics of Daptomycin [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT Data from subjects in nine phase 1 ( n = 153) and six phase 2/3 ( n = 129) clinical trials were combined to identify factors contributing to interindividual variability in daptomycin pharmacokinetics (PK). Over 30 covariates were considered.
Barry, Dvorchik, Robert D, Arbeit, Julia, Chung, Susan, Liu, William, Knebel, Helen, Kastrissios   +5 more
openaire   +2 more sources

Genetic Parameter Estimates for Metabolizing Two Common Pharmaceuticals in Swine

Frontiers in Genetics, 2018
In livestock, the regulation of drugs used to treat livestock has received increased attention and it is currently unknown how much of the phenotypic variation in drug metabolism is due to the genetics of an animal.
Jeremy T. Howard, Melissa S. Ashwell, Ronald E. Baynes, James D. Brooks, James L. Yeatts, Christian Maltecca   +5 more
doaj   +1 more source

Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin

Pharmaceutics, 2022
Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic insight into biological ...
Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G. Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M. Svensson, Michael P. Menden, Ulrika S. H. Simonsson, on behalf of the UNITE4TB Consortium   +11 more
doaj   +1 more source

Modeling Approach to Optimizing Dose Regimen of Vancomycin for Chinese Pediatric Patients with Gram-Positive Bacterial Infections

Frontiers in Pharmacology, 2021
The aim of this study was to establish the population pharmacokinetics (PK) model of Vancomycin for Chinese pediatric patients which can extrapolate to whole age periods by bridging the published adult population PK model and the established pediatric ...
Kai Shen, Yaxin Fan, Minjie Yang, Yuancheng Chen, Jinhao Tao, Guoping Lu, Hong Zhang, Qiwei Huang, Jing Zhang   +8 more
doaj   +1 more source

Gene co-expression network analysis identifies porcine genes associated with variation in metabolizing fenbendazole and flunixin meglumine in the liver

Scientific Reports, 2017
Identifying individual genetic variation in drug metabolism pathways is of importance not only in livestock, but also in humans in order to provide the ultimate goal of giving the right drug at the right dose at the right time.
Jeremy T. Howard, Melissa S. Ashwell, Ronald E. Baynes, James D. Brooks, James L. Yeatts, Christian Maltecca   +5 more
doaj   +1 more source

Population Pharmacokinetics of Lithium in Young Pediatric Patients With Intellectual Disability

Frontiers in Pharmacology, 2021
Background: Lithium is a well-established treatment for bipolar disorders and has been shown to be neuroprotective, and thus low doses might be useful for the treatment of childhood brain injury and neurological sequelae.
Junying Yuan, Bohao Zhang, Bohao Zhang, Yiran Xu, Xiaoli Zhang, Juan Song, Wenhao Zhou, Kai Hu, Dengna Zhu, Lirong Zhang, Fengmin Shao, Shusheng Zhang, Junjie Ding, Junjie Ding, Changlian Zhu, Changlian Zhu, Changlian Zhu   +16 more
doaj   +1 more source

Population Pharmacokinetics of Teicoplanin in Children [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT Teicoplanin is frequently administered to treat Gram-positive infections in pediatric patients. However, not enough is known about the pharmacokinetics (PK) of teicoplanin in children to justify the optimal dosing regimen.
Ramos-Martin V., Paulus S., Siner S., Scott E., Padmore K., Newland P., Drew R. J., Felton T. W., Docobo-Perez F., Pizer B., Pea F., Peak M., Turner M. A., Beresford M. W., Hope W. W.   +14 more
openaire   +6 more sources

Population Pharmacokinetics of CC-122

Clinical Pharmacology: Advances and Applications, 2021
Yiming Cheng,1 Jian Chen,2 Michael Pourdehnad,3 Simon Zhou,1 Yan Li1 1Clinical Pharmacology & Pharmacometrics, Bristol Myers Squibb, Summit, NJ, USA; 2Non-Clinical Research & Development, Bristol Myers Squibb, Summit, NJ, USA; 3Early Clinical ...
Cheng Y, Chen J, Pourdehnad M, Zhou S, Li Y   +4 more
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