Results 31 to 40 of about 112,978 (213)

ADME gene polymorphisms do not influence the pharmacokinetics of docetaxel: Results from a population pharmacokinetic study in Indian cancer patients

Cancer Medicine, 2021
Background Pharmacokinetics (PK) of docetaxel is characterized by high inter‐individual variability (IIV). While covariate models that explain the PK variability of docetaxel exist, not much is known about the effects of genetic variations on docetaxel ...
Anand Patil, Bharati Shriyan, Parsshava Mehta, Mrudula Patil, Murari Gurjar, Manjunath Nookala, Vijay Patil, Amit Joshi, Vanita Noronha, Kumar Prabhash, Vikram Gota   +10 more
doaj   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Population Pharmacokinetic/Pharmacodynamic Model-Guided Dosing Optimization of a Novel Sedative HR7056 in Chinese Healthy Subjects

Frontiers in Pharmacology, 2018
HR7056 is a new benzodiazepine, showing more faster acting onset and recovery than currently available short-acting sedatives. To avoid inadequate anesthesia and predict return of cognition, allowing for immediate neurological evaluation, HR7056 ...
Ying Zhou, Ying Zhou, Pei Hu, Yuguang Huang, Nuoer Sang, Kaicheng Song, Hongyun Wang, Jinhua Wen, Ji Jiang, Xia Chen, Xia Chen   +10 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Pharmacokinetics of Odronextamab, A Bispecific T‐Cell‐Engaging Antibody, in Adult Patients With Relapsed or Refractory B‐Cell Non‐Hodgkin Lymphoma

CPT: Pharmacometrics & Systems Pharmacology
Non‐Hodgkin lymphoma (NHL) is the fifth most common malignancy and accounts for 5% of all cancers in the US, with the largest proportion being B‐cell CD20 positive NHL.
Marçal Bravo Padros, Daniela J. Conrado, Kamal Srinivasan, Lutz O. Harnisch, John D. Davis, Min Zhu   +5 more
doaj   +1 more source

Population Pharmacokinetics of Busulfan and Its Metabolite Sulfolane in Patients with Myelofibrosis Undergoing Hematopoietic Stem Cell Transplantation

Pharmaceutics, 2022
For patients with myelofibrosis, allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative treatment to date. Busulfan-based conditioning regimens are commonly used, although high inter-individual variability (IIV) in ...
Adrin Dadkhah, Sebastian Georg Wicha, Nicolaus Kröger, Alexander Müller, Christoph Pfaffendorf, Maria Riedner, Anita Badbaran, Boris Fehse, Claudia Langebrake   +8 more
doaj   +1 more source

Influential predictors of azithromycin pharmacokinetics: a systematic review of population pharmacokinetics

Annals of Medicine
Introduction Azithromycin exhibits significant pharmacokinetic variability. Thus, dosage optimization is crucial for optimal therapeutic outcomes. This systematic review aims to analyze the population pharmacokinetics (PopPK) of azithromycin and identify
Janthima Methaneethorn, Zheng Jiao, Rowan AlEjielat, Totsapol Jirasomprasert   +3 more
doaj   +1 more source

Population Pharmacokinetic Modelling of Orally Administered Doxycycline to Rabbits at Different Ages

Antibiotics, 2021
Doxycycline is a well-tolerated tetracycline antibiotic, registered for use in rabbits and administered for treatment of bacterial infections in this animal species.
Rositsa Mileva, Anton Rusenov, Aneliya Milanova   +2 more
doaj   +1 more source

Shape Memory Microneedle to Prevent Risks of Reproductive Hormone Therapy by Switching Sustained to Burst Release Under a Single Transdermal Insertion

Advanced Functional Materials, EarlyView.
A shape‐memory microneedle system enables reproductive hormone therapy through a single transdermal insertion. The X‐shaped device sustains follicle‐stimulating hormone release for three days, and mild heating restores the O shape to trigger burst human chorionic gonadotropin release.
Sungwoo Cho, Hyunjae Kim, Seung Eun Yu, Sangmin Lee, Ji Youn Lee, Mi‐Lan Kang, Kang Suk Lee, Young Sik Choi, Hak‐Joon Sung   +8 more
wiley   +1 more source