Results 31 to 40 of about 114,024 (159)

Population pharmacokinetics and dosing simulations of imipenem in serious bacteraemia in immunocompromised patients with febrile neutropenia

Journal of Pharmacological Sciences, 2015
The aims of this study were to i) reveal the population pharmacokinetics; and ii) assess the probability of target attainment (PTA) and cumulative fraction of response (CFR) (defined as the expected population PTA for a specific drug dose and a specific ...
Sutep Jaruratanasirikul, Wibul Wongpoowarak, Monchana Jullangkoon, Maseetoh Samaeng   +3 more
doaj   +1 more source

Population Pharmacokinetic and Pharmacodynamic Modeling for the Prediction of the Extended Amlitelimab Phase 3 Dosing Regimen in Atopic Dermatitis

CPT: Pharmacometrics & Systems Pharmacology
Amlitelimab is a fully human, nondepleting, anti‐OX40 ligand monoclonal antibody being investigated for the treatment of moderate‐to‐severe atopic dermatitis (AD) in adults and adolescents.
Gilles Tiraboschi, Kim Papp, Thomas Bieber, Stephan Weidinger, Lisa Beck, Chih‐Hung Lee, John T. O'Malley, Karl Yen, Charlotte Bernigaud, David Fabre, Fabrice Hurbin   +10 more
doaj   +1 more source

ADME gene polymorphisms do not influence the pharmacokinetics of docetaxel: Results from a population pharmacokinetic study in Indian cancer patients

Cancer Medicine, 2021
Background Pharmacokinetics (PK) of docetaxel is characterized by high inter‐individual variability (IIV). While covariate models that explain the PK variability of docetaxel exist, not much is known about the effects of genetic variations on docetaxel ...
Anand Patil, Bharati Shriyan, Parsshava Mehta, Mrudula Patil, Murari Gurjar, Manjunath Nookala, Vijay Patil, Amit Joshi, Vanita Noronha, Kumar Prabhash, Vikram Gota   +10 more
doaj   +1 more source

Population Pharmacokinetic/Pharmacodynamic Model-Guided Dosing Optimization of a Novel Sedative HR7056 in Chinese Healthy Subjects

Frontiers in Pharmacology, 2018
HR7056 is a new benzodiazepine, showing more faster acting onset and recovery than currently available short-acting sedatives. To avoid inadequate anesthesia and predict return of cognition, allowing for immediate neurological evaluation, HR7056 ...
Ying Zhou, Ying Zhou, Pei Hu, Yuguang Huang, Nuoer Sang, Kaicheng Song, Hongyun Wang, Jinhua Wen, Ji Jiang, Xia Chen, Xia Chen   +10 more
doaj   +1 more source

Pharmacokinetics of Odronextamab, A Bispecific T‐Cell‐Engaging Antibody, in Adult Patients With Relapsed or Refractory B‐Cell Non‐Hodgkin Lymphoma

CPT: Pharmacometrics & Systems Pharmacology
Non‐Hodgkin lymphoma (NHL) is the fifth most common malignancy and accounts for 5% of all cancers in the US, with the largest proportion being B‐cell CD20 positive NHL.
Marçal Bravo Padros, Daniela J. Conrado, Kamal Srinivasan, Lutz O. Harnisch, John D. Davis, Min Zhu   +5 more
doaj   +1 more source

Population Pharmacokinetics of Busulfan and Its Metabolite Sulfolane in Patients with Myelofibrosis Undergoing Hematopoietic Stem Cell Transplantation

Pharmaceutics, 2022
For patients with myelofibrosis, allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative treatment to date. Busulfan-based conditioning regimens are commonly used, although high inter-individual variability (IIV) in ...
Adrin Dadkhah, Sebastian Georg Wicha, Nicolaus Kröger, Alexander Müller, Christoph Pfaffendorf, Maria Riedner, Anita Badbaran, Boris Fehse, Claudia Langebrake   +8 more
doaj   +1 more source

Population pharmacokinetics: an overview

Australian Prescriber, 2014
The pharmacokinetics of a drug refers to how it is handled by the body. This includes absorption, distribution, metabolism and elimination.
openaire   +3 more sources

Influential predictors of azithromycin pharmacokinetics: a systematic review of population pharmacokinetics

Annals of Medicine
Introduction Azithromycin exhibits significant pharmacokinetic variability. Thus, dosage optimization is crucial for optimal therapeutic outcomes. This systematic review aims to analyze the population pharmacokinetics (PopPK) of azithromycin and identify
Janthima Methaneethorn, Zheng Jiao, Rowan AlEjielat, Totsapol Jirasomprasert   +3 more
doaj   +1 more source

Population Pharmacokinetic Modelling of Orally Administered Doxycycline to Rabbits at Different Ages

Antibiotics, 2021
Doxycycline is a well-tolerated tetracycline antibiotic, registered for use in rabbits and administered for treatment of bacterial infections in this animal species.
Rositsa Mileva, Anton Rusenov, Aneliya Milanova   +2 more
doaj   +1 more source

Pemodelan Farmakokinetika Berbasis Populasi dengan R: Model Dua Kompartemen Ekstravaskuler

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2018
A Tutorial of two-compartment extravascular population-based pharmacokinetics modeling was performed by differential equations and non-linear mixed effect model approach.
Dion Notario
doaj   +1 more source