Results 31 to 40 of about 5,090,795 (152)

Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution

Chinese Medical Journal, 2015
Background: High-dose methotrexate (HD-MTX) with folinic acid (leucovorin) rescue is the gold standard therapy in the treatment of osteosarcoma. The plasma concentration of MTX is closely related to efficacy and toxicity.
Wei Zhang, Qing Zhang, Xiaohuang Tian, Haitao Zhao, Wei Lu, Jiancun Zhen, Xiaohui Niu   +6 more
doaj   +1 more source

Population Pharmacokinetics and Dosing Optimization of Vancomycin in Pediatric Liver Transplant Recipients

Microbiology Spectrum, 2021
Methicillin-resistant Staphylococcus aureus infections are a significant cause of morbidity and mortality in pediatric liver transplant (LT) recipients.
Kensuke Shoji, Jumpei Saito, Hidenori Nakagawa, Takanori Funaki, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Jeremiah D. Momper, Edmund V. Capparelli, Isao Miyairi   +9 more
doaj   +1 more source

Enrofloxacin Dose Optimization for the Treatment of Colibacillosis in Broiler Chickens Using a Drinking Behaviour Pharmacokinetic Model

Antibiotics, 2021
Enrofloxacin is frequently administered via drinking water for the treatment of colibacillosis in broiler chickens. However, the EMA/CVMP has urged to re-evaluate historically approved doses, especially for antimicrobials administered via drinking water.
Robin Temmerman, Ludovic Pelligand, Wim Schelstraete, Gunther Antonissen, An Garmyn, Mathias Devreese   +5 more
doaj   +1 more source

The Effects of Pharmacogenetics on Pharmacokinetics\ud of Artemisinin-Based Combinations in Malaria Patients [PDF]

, 2009
Malaria is a vector-borne infectious disease caused by protozoan parasites of the genus Plasmodium. If not treated appropriately, human P. falciparum malaria can quickly become life-threatening, leading to an estimated 900’000 annual deaths globally. Key
Hodel, Eva Maria
core  

Population pharmacokinetics of Phenytoin in critically ill children

, 2014
The objective was to study the population pharmacokinetics of bound and unbound phenytoin in critical ill children, including influences on the protein binding profile.
Karin van Breda, Norris, Ross, Kelly Foster, Tu, Quyen Tu, Riney, Kate, van Breda, Karin, Hennig, Stefanie, Kate Riney, Bruce Charles, Stefanie Hennig, Bruce Lister, Foster, Kelly, Quyen Tu, Lister, Bruce, Charles, Bruce, Tu, Quyen, Ross Norris   +16 more
core   +1 more source

Population Pharmacokinetic and Pharmacodynamic Modeling for the Prediction of the Extended Amlitelimab Phase 3 Dosing Regimen in Atopic Dermatitis

CPT: Pharmacometrics & Systems Pharmacology
Amlitelimab is a fully human, nondepleting, anti‐OX40 ligand monoclonal antibody being investigated for the treatment of moderate‐to‐severe atopic dermatitis (AD) in adults and adolescents.
Gilles Tiraboschi, Kim Papp, Thomas Bieber, Stephan Weidinger, Lisa Beck, Chih‐Hung Lee, John T. O'Malley, Karl Yen, Charlotte Bernigaud, David Fabre, Fabrice Hurbin   +10 more
doaj   +1 more source

Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria

, 2007
The study aimed to characterize the population pharmacokinetics of amodiaquine (AQ) and its major metabolite N-desethylamodiaquine (N-DEAQ), and to assess the correlation between exposure to N-DEAQ and treatment outcome.
Msellem, Mwinyi, Ali, Abdullah S., Friberg Hietala, Sofia,, Bhattarai, Achuyt, Röshammar, Daniel,, Hombhanje, Francis W., Kaneko, Akira, Björkman, Anders, Ashton, Michael,, Strömberg, Johan   +9 more
core   +1 more source

Effect of Laparoscopic Sleeve Gastrectomy on the Pharmacokinetics of Oral Omeprazole Using a Population Approach

, 2022
Omeprazole is commonly prescribed to obese patients and patients after laparoscopic sleeve gastrectomy (LSG). The pharmacokinetics of oral omeprazole after LSG are still unknown. Therefore, the aim of this study was to investigate the pharmacokinetics of
Luo, Ping, Shaihong Zhu, Yaqi Lin, Kaifeng Chen, Liyong Zhu, Qi Pei, Ping Luo, Zhu, Liyong, Pei, Qi, Qin Ding, Zhu, Shaihong, Yang, Nan, Chen, Kaifeng, Ding, Qin, Huang, Shuqi, Shuqi Huang, Nan Yang, Lin, Yaqi   +17 more
core   +1 more source

Population pharmacokinetics and dosing simulations of imipenem in serious bacteraemia in immunocompromised patients with febrile neutropenia

Journal of Pharmacological Sciences, 2015
The aims of this study were to i) reveal the population pharmacokinetics; and ii) assess the probability of target attainment (PTA) and cumulative fraction of response (CFR) (defined as the expected population PTA for a specific drug dose and a specific ...
Sutep Jaruratanasirikul, Wibul Wongpoowarak, Monchana Jullangkoon, Maseetoh Samaeng   +3 more
doaj   +1 more source

Pharmacokinetics of Odronextamab, A Bispecific T‐Cell‐Engaging Antibody, in Adult Patients With Relapsed or Refractory B‐Cell Non‐Hodgkin Lymphoma

CPT: Pharmacometrics & Systems Pharmacology
Non‐Hodgkin lymphoma (NHL) is the fifth most common malignancy and accounts for 5% of all cancers in the US, with the largest proportion being B‐cell CD20 positive NHL.
Marçal Bravo Padros, Daniela J. Conrado, Kamal Srinivasan, Lutz O. Harnisch, John D. Davis, Min Zhu   +5 more
doaj   +1 more source