Results 41 to 50 of about 114,024 (159)

Application of population pharmacokinetics to cladribine [PDF]

BMC Pharmacology, 2005
Abstract Background The nucleoside analog cladribine is used for the treatment of a variety of indolent B- and T-cell lymphoid malignancies. The primary aim of the study was to evaluate the population distribution of pharmacokinetic parameters in patients undergoing treatment with cladribine and to detect
Lindemalm, Synnöve, Savic, Radojka M, Karlsson, Mats O, Juliusson, Gunnar, Liliemark, Jan, Albertioni, Freidoun   +5 more
openaire   +2 more sources

Tobramycin population pharmacokinetics in neonates* [PDF]

Clinical Pharmacology & Therapeutics, 1997
To establish a tobramycin dosing schedule for neonates of various gestational ages.This was a retrospective study with prospective validation. A retrospective study in 470 neonates, with suspected septicemia in the first week of life, was performed. All patients received tobramycin according to the following scheme: neonates with a gestational age of ...
de Hoog, Matthijs, Schoenmaker, RC, Mouton, Johan, van den Anker, John   +3 more
openaire   +3 more sources

Population Pharmacokinetics of Vancomycin in Thai Patients

The Scientific World Journal, 2012
Population pharmacokinetics of vancomycin in Thai adult patients was determined by non-linear mixed-effects approach using 319 vancomycin serum concentrations from 212 patients.
Tunggul Adi Purwonugroho, Suvatna Chulavatnatol, Yupaporn Preechagoon, Busba Chindavijak, Kumthorn Malathum, Pakwan Bunuparadah   +5 more
doaj   +1 more source

A Population Pharmacokinetic Model to Inform Extension of the Eteplirsen Dosing Regimen Across the Broad DMD Population

CPT: Pharmacometrics & Systems Pharmacology
Duchenne muscular dystrophy (DMD) is characterized by progressive, irreversible muscle damage that usually leads to premature death from cardiac or respiratory failure.
Yogesh Patel, Larry Orogun, Nicole Yocum, Louise R. Rodino‐Klapac, Lilly East   +4 more
doaj   +1 more source

Population Pharmacokinetic Analysis and Simulation of Alternative Dosing Regimens for Biosimilars to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis

Pharmaceutics
Efficacy to biologics in rheumatoid arthritis (RA) patients is variable and is likely influenced by each patient’s circulating drug levels. Using modelling and simulation, the aim of this study was to investigate whether adalimumab and etanercept ...
Stephanie F. Ling, Kayode Ogungbenro, Adam S. Darwich, Amirah Binti Mohammad Ariff, Nisha Nair, James Bluett, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant   +11 more
doaj   +1 more source

Population Pharmacokinetics of Tigecycline: A Systematic Review

Drug Design, Development and Therapy, 2022
Can-Can Zhou,1,* Fang Huang,1,* Jing-Ming Zhang,1 Yu-Gang Zhuang2 1Department of Pharmacy, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 2Department of Emergency Medicine ...
Zhou CC, Huang F, Zhang JM, Zhuang YG
doaj  

Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

Malaria Journal, 2019
Background The World Health Organization (WHO) recommends combinations of an artemisinin derivative plus an anti-malarial drug of longer half-life as treatment options for uncomplicated Plasmodium falciparum infections.
Monia Guidi, Thomas Mercier, Manel Aouri, Laurent A. Decosterd, Chantal Csajka, Bernhards Ogutu, Gwénaëlle Carn, Jean-René Kiechel   +7 more
doaj   +1 more source

Population pharmacokinetics of olprinone in healthy male volunteers

Clinical Pharmacology: Advances and Applications, 2014
Takayuki Kunisawa,1 Hidefumi Kasai,2 Makoto Suda,2 Manabu Yoshimura,3 Ami Sugawara,3 Yuki Izumi,3 Takafumi Iida,3 Atsushi Kurosawa,3 Hiroshi Iwasaki3 1Surgical Operation Department, Asahikawa Medical University Hospital, Hokkaido, Japan; 2Clinical Study ...
Kunisawa T, Kasai H, Suda M, Yoshimura M, Sugawara A, Izumi Y, Iida T, Kurosawa A, Iwasaki H   +8 more
doaj  

Population pharmacokinetics and pharmacodynamics of cysteamine in nephropathic cystinosis patients

Orphanet Journal of Rare Diseases, 2011
Background Nephropathic cystinosis is an autosomal recessive disorder resulting in an impaired transport of cystine trough the lysosomal membrane causing an accumulation of free cystine in lysosomes.
Bouazza Naïm, Tréluyer Jean-Marc, Ottolenghi Chris, Urien Saik, Deschenes Georges, Ricquier Daniel, Niaudet Patrick, Chadefaux-Vekemans Bernadette   +7 more
doaj   +1 more source

Dosage Optimization of Treatments Using Population Pharmacokinetic Modeling and Simulation

CHIMIA, 2012
Pharmacokinetic variability in drug levels represent for some drugs a major determinant of treatment success, since sub-therapeutic concentrations might lead to toxic reactions, treatment discontinuation or inefficacy.
M. Guidi, Mona Arab-Alameddine, Margalida Rotger, Manel Aouri, Amalio Telenti, Laurent A. Decosterd, Thierry Buclin, Chantal Csajka   +7 more
doaj   +1 more source