Results 41 to 50 of about 5,090,795 (152)

Population Pharmacokinetic/Pharmacodynamic Model-Guided Dosing Optimization of a Novel Sedative HR7056 in Chinese Healthy Subjects

Frontiers in Pharmacology, 2018
HR7056 is a new benzodiazepine, showing more faster acting onset and recovery than currently available short-acting sedatives. To avoid inadequate anesthesia and predict return of cognition, allowing for immediate neurological evaluation, HR7056 ...
Ying Zhou, Ying Zhou, Pei Hu, Yuguang Huang, Nuoer Sang, Kaicheng Song, Hongyun Wang, Jinhua Wen, Ji Jiang, Xia Chen, Xia Chen   +10 more
doaj   +1 more source

ADME gene polymorphisms do not influence the pharmacokinetics of docetaxel: Results from a population pharmacokinetic study in Indian cancer patients

Cancer Medicine, 2021
Background Pharmacokinetics (PK) of docetaxel is characterized by high inter‐individual variability (IIV). While covariate models that explain the PK variability of docetaxel exist, not much is known about the effects of genetic variations on docetaxel ...
Anand Patil, Bharati Shriyan, Parsshava Mehta, Mrudula Patil, Murari Gurjar, Manjunath Nookala, Vijay Patil, Amit Joshi, Vanita Noronha, Kumar Prabhash, Vikram Gota   +10 more
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Influential predictors of azithromycin pharmacokinetics: a systematic review of population pharmacokinetics

Annals of Medicine
Introduction Azithromycin exhibits significant pharmacokinetic variability. Thus, dosage optimization is crucial for optimal therapeutic outcomes. This systematic review aims to analyze the population pharmacokinetics (PopPK) of azithromycin and identify
Janthima Methaneethorn, Zheng Jiao, Rowan AlEjielat, Totsapol Jirasomprasert   +3 more
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An Algorithm for Nonparametric Estimation of a Multivariate Mixing Distribution with Applications to Population Pharmacokinetics

, 2020
Population pharmacokinetic (PK) modeling has become a cornerstone of drug development and optimal patient dosing. This approach offers great benefits for datasets with sparse sampling, such as in pediatric patients, and can describe between-patient ...
Michael N. Neely, Roger W. Jelliffe, Tatiana Tatarinova, Alan Schumitzky, David S. Bayard, Mike van Guilder, Walter M. Yamada, Alona Kryshchenko, Jay Bartroff, James V. Burke, Robert Leary   +10 more
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Meltdose Tacrolimus Population Pharmacokinetics and Limited Sampling Strategy Evaluation in Elderly Kidney Transplant Recipients

, 2023
Background: Meltdose tacrolimus (Envarsus®) has been marketed as a formulation achieving a more consistent tacrolimus exposure. Due to the narrow therapeutic window of tacrolimus, dose individualization is essential.
Soufian Meziyerh, Tom C. Zwart, Paul J. M. van der Boog, Koen van Duin, Dirk Jan A. R. Moes, Esther E. Nijgh, Aiko P. J. de Vries, Jasper Kamp   +7 more
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Pemodelan Farmakokinetika Berbasis Populasi dengan R: Model Dua Kompartemen Ekstravaskuler

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2018
A Tutorial of two-compartment extravascular population-based pharmacokinetics modeling was performed by differential equations and non-linear mixed effect model approach.
Dion Notario
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Population pharmacokinetics of asciminib in tyrosine kinase inhibitor-treated patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic and acute phases

, 2022
Background: Asciminib, a first-in-class highly potent BCR-ABL1 inhibitor has shown superior efficacy compared to the existing tyrosine kinase inhibitor TKI in patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase ...
Hoch, Matthias, Sy, Sherwin, Lorenzo, Sebastien, Ho, Yu-Yun, Li, Ying Fei, Combes, Francois Pierre   +5 more
core   +1 more source

Population Pharmacokinetics of Vancomycin in Thai Patients

The Scientific World Journal, 2012
Population pharmacokinetics of vancomycin in Thai adult patients was determined by non-linear mixed-effects approach using 319 vancomycin serum concentrations from 212 patients.
Tunggul Adi Purwonugroho, Suvatna Chulavatnatol, Yupaporn Preechagoon, Busba Chindavijak, Kumthorn Malathum, Pakwan Bunuparadah   +5 more
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A Population Pharmacokinetic Model to Inform Extension of the Eteplirsen Dosing Regimen Across the Broad DMD Population

CPT: Pharmacometrics & Systems Pharmacology
Duchenne muscular dystrophy (DMD) is characterized by progressive, irreversible muscle damage that usually leads to premature death from cardiac or respiratory failure.
Yogesh Patel, Larry Orogun, Nicole Yocum, Louise R. Rodino‐Klapac, Lilly East   +4 more
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Population Pharmacokinetic Analysis and Simulation of Alternative Dosing Regimens for Biosimilars to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis

Pharmaceutics
Efficacy to biologics in rheumatoid arthritis (RA) patients is variable and is likely influenced by each patient’s circulating drug levels. Using modelling and simulation, the aim of this study was to investigate whether adalimumab and etanercept ...
Stephanie F. Ling, Kayode Ogungbenro, Adam S. Darwich, Amirah Binti Mohammad Ariff, Nisha Nair, James Bluett, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant   +11 more
doaj   +1 more source