Results 51 to 60 of about 114,024 (159)

Population Pharmacokinetics of Dasatinib in Healthy Subjects

Pharmaceuticals
Background and Objectives: Dasatinib is one of the tyrosine kinase inhibitors. The main use of these agents is inhibition of cancerous cell proliferation.
Walaa B. Hassouneh, Mutasim A. Al-Ghazawi, Mohammad I. Saleh, Naji Najib   +3 more
doaj   +1 more source

Vancomycin population pharmacokinetics in patients with burns

Frontiers in Medicine
BackgroundVancomycin is used to treat severe infections caused by methicillin-resistant gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA).
Yan Shi, Yijin Yao, Xiaoshuang He, Xiaolan Bian, Xiaolan Bian, Xunben Yu, Jie Fang, Huan Wang, Yi Dou   +8 more
doaj   +1 more source

Population Pharmacokinetics of Tranexamic Acid in Chinese Population Undergoing Cardiac Surgery with Cardiopulmonary Bypass

Drug Design, Development and Therapy
Yue Liu,1 Chenghui Zhou,2 Hong Lv,1 Lei Tian,3 Juanjuan Jiang,3 Jia Shi1 1Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and ...
Liu Y, Zhou C, Lv H, Tian L, Jiang J, Shi J   +5 more
doaj  

Population Pharmacokinetic and Pharmacodynamic Study of Palbociclib in Children and Young Adults with Recurrent, Progressive, or Refractory Brain Tumors

Pharmaceutics
Background/Objectives: Palbociclib, an oral CDK 4/6 inhibitor, was evaluated in a Pediatric Brain Tumor Consortium (PBTC) phase 1 (NCT02255461; PBTC-042) study to treat children and young adults with recurrent, progressive, or refractory brain tumors ...
John C. Panetta, Nicholas S. Selvo, David Van Mater, Clinton F. Stewart   +3 more
doaj   +1 more source

Population Pharmacokinetic Modeling and Exposure‐Response Analyses of Nemtabrutinib in Patients With Hematologic Malignancies

CPT: Pharmacometrics & Systems Pharmacology
Nemtabrutinib is a Bruton's tyrosine kinase (BTK) inhibitor under clinical investigation in patients with hematologic malignancies, including chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL).
Chiara C. Kemal, Thijs J. Zweers, Elke H. J. Krekels, Manash S. Chatterjee   +3 more
doaj   +1 more source

Population Pharmacokinetic and Exposure‐Response Analyses of Ibrutinib Combined With Bendamustine and Rituximab in Patients With Mantle Cell Lymphoma

CPT: Pharmacometrics & Systems Pharmacology
Efficacy and safety of ibrutinib 560 mg once daily or placebo combined with bendamustine and rituximab (BR) were assessed in patients with mantle cell lymphoma in a randomized phase 3 study (SHINE).
Per Olsson Gisleskog, Belén Valenzuela, Nicoline Treijtel, Sanjay Deshpande, Todd Henninger, Juan José Perez‐Ruixo   +5 more
doaj   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Immunoglobulins: A Systematic Review. [PDF]

Clin Pharmacokinet
van der Zeeuw SL, van Tilburg SJ, Jacobs BC, Koch BCP, Dalm VASH, Crombag MBS, Preijers T.   +6 more
europepmc   +1 more source

Nicotine Gum in Thai Smokers with Different CYP2A6 Enzymes: A Population Pharmacokinetic Analysis

Siriraj Medical Journal
Objective: Despite the popularity of nicotine gum in Thailand, population pharmacokinetics of nicotine gum in the Thai population has not been investigated.
Kathy Moesan, Khwanruan Phetnoi, Napakkawat Buathong, Pajaree Chariyavilaskul, Thitima Wattanavijitkul, Waroonrat Sukarnjanaset   +5 more
doaj  

Population Pharmacokinetics and Dosing Simulations of Pentobarbital in the Pediatric Population. [PDF]

J Clin Pharmacol
Helfer VE, Medina-Aymerich L, Muller WJ, Meyer M, Al-Uzri A, McCulloh R, Hornik CD, Balevic SJ, Greenberg RG, Benjamin DK, Anderson SG, Gonzalez D, Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee.   +12 more
europepmc   +1 more source

Bayesian Estimation of Vancomycin Exposure and Population Pharmacokinetics in Obese Patients. [PDF]

Antibiotics (Basel)
Chun HJ, Choi HG, Bang ES, Kyun JO, Kim YR, Kim EJ, Kim SH.   +6 more
europepmc   +1 more source