Results 41 to 50 of about 1,894 (264)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Jesus and the Jewish covenants

open access: yesVerbum et Ecclesia
Jesus established a New Covenant which we commemorate regularly at the Holy Communion. This New Covenant can only be fully appreciated in the context of the Old Testament (OT).
Volker Kessler
doaj   +1 more source

Covenant design in financial contracts: a case study of the private equity acquisition of HCA

open access: yesInternational Journal of Strategic Property Management, 2015
A buyout deal involves several parties, including private equity firms, the target company, and lending banks. All these parties are legally connected by contractual arrangements, and covenants among all interest parties are important.
Tzu-Wen Wei   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Financial Intermediation and Fixed Capital Formation in Zimbabwe

open access: yesEurasian Journal of Economic and Business Studies, 2023
Business sustainability is heavily constrained by the shortage of affordable finance of adequate duration and quality. This affects producers and traders' capacity to reorganize their production and exchange systems to attain dynamic competitiveness ...
Upenyu Sakarombe, Lloyd Badze
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

THE COVENANTS OF THE FATHERS IN ARISTOTLIAN “ATHENIAN POLITY” AND “POLITICS”: THE EXPERIENCE OF INTERPRETATION IN THE CONTEXT OF MEMORY STUDIES

open access: yesДокса, 2017
Tradition, heritage, memory, historical consciousness, identity are categories of memory studies, interest in which is constantly growing today. In this article the author attempts to examine the ancient «covenants of the fathers» described by Aristotle ...
Марія Загурська
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Religious Pluralism and Civic Rights in a “Muslim Nation”: An Analysis of Prophet Muhammad’s Covenants with Christians

open access: yesReligions, 2016
This article examines the roles that religious pluralism and civic rights played in Prophet Muhammad’s vision of a “Muslim nation”. I demonstrate how Muhammad desired a pluralistic society in which citizenship and equal rights were granted to all people ...
Craig Considine
doaj   +1 more source

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