Results 61 to 70 of about 1,894 (264)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Conservation covenants for ecosystem restoration: adapting an old instrument to a new global conservation challenge?

Frontiers in Conservation Science
Conservation covenants are an important legal tool for enabling private land conservation, whose significance to policymakers has recently grown in light of new global commitments to expand areas of land and water protected and restored.
Benjamin J. Richardson, Sarah Brugler, James A. Fitzsimons, James A. Fitzsimons, James A. Fitzsimons, Phillipa C. McCormack, Afshin Akhtar-Khavari   +6 more
doaj   +1 more source

“Whoever Harms a Dhimmī I Shall Be His Foe on the Day of Judgment”: An Investigation into an Authentic Prophetic Tradition and Its Origins from the Covenants

Religions, 2019
The ḥadīth, “whoever harms a dhimmī I shall be his foe on the Day of Judgment’, can be found as an end clause to covenants which the Prophet Muḥammad issued to Christian, Jewish, and Magian communities.
Ahmed El-Wakil
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

The Human Rights Covenants at 60: A Reflection on Achievements and Challenges

Netherlands Quarterly of Human Rights
The passing of symbolic milestones in 2026, such as the 60th anniversary of the adoption of the International Human Rights Covenants and the 20th anniversary of the UN Human Rights Council, arrives at a time of palpable gloom in the international human ...
Ian Seiderman
doaj   +1 more source

Níveis diferenciados de governança corporativa e a probabilidade de violação dos covenants financeiros

Revista de Contabilidade e Organizações, 2020
A governança corporativa e os covenants financeiros exercem papéis complementares no monitoramento das companhias na medida em que reduzem os conflitos de interesse entre as partes envolvidas durante a confecção de contratos de dívida.
Willams da Conceição de Oliveira, Danilo Soares Monte-Mor   +1 more
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Private protected areas in Australia: current status and future directions

Nature Conservation, 2015
Despite the recognised importance of private land for biodiversity conservation, there has been little research into systems of private protected areas at a country-wide level. Here I look at definitions, legislation, ownership, management approaches and
James A. Fitzsimons
doaj   +1 more source