Results 41 to 50 of about 82,354 (261)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
EDIS, 2019 The article will be a general overview of the benefits of cover crops in citrus, as well as some of the challenges. Cover crops in citrus can improve soil health, which can impact root growth and nutrient uptake of citrus, as well as reduce weed density.
Sarah Strauss +5 more
doaj
Agronomy, 2020 Diseases caused by soilborne pathogens are a major limitation to field grown nursery production. The application of cover crops for soilborne disease management has not been widely investigated in a woody ornamental nursery production system.
Milan Panth +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The nitrogen value of cover crops: How much N can cover crops replace?
Agricultural & Environmental LettersAchieving high corn yields while reducing fertilizer losses seems attainable through nitrogen (N) management decisions that include the use of cover crops (CCs).
Guillermo S. Marcillo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Post Corn Silage, Going to Soybean: Introduce a Fall Rye Cover Crop
, 2020 This publication is intended to provide a starting point for farmers who are new to growing cover crops. With experience, farmers may fine-tune the use of cover crops for their systems.The following recipe provides an introductory approach to integrating
Ogilvie, Cameron +5 more
core
AgronomyPlanting cover crops can improve soil health and help to sustain agricultural crop yields. In northern climates where corn (Zea mays L.) and soybean (Glycine max L.) are grown, cover crop biomass production can be low.
Hans W. Klopp
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source