Results 91 to 100 of about 3,733,183 (293)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Building resilient hospitals in the Eastern Mediterranean Region: lessons from the COVID-19 pandemic

BMJ Global Health, 2022
Merette Khalil, Awad Mataria, Hamid Ravaghi   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

State Implementation of National Health Reform: Harnessing Federal Resources to Meet State Policy Goals [PDF]

, 2010
Discusses state options for maximizing coverage and access to care; reforming the health insurance market; holding insurers accountable for high-quality, affordable coverage; restructuring healthcare delivery and financing; and cutting budget ...
Stan Dorn
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Determinants of incomplete vaccination against polio by 2 years of age in Canada: A cross-sectional study using the Childhood National Immunization Coverage Survey (CNICS)

Vaccine: X
Background: Canada has not reached the national vaccination coverage goal of 95 % for polio vaccination in 2-year-old children. The objective of this study was to examine determinants of incomplete polio vaccination (receipt of less than 3 doses of a ...
Israa Zareef, Kristina Sabou, Anna Maria Frescura, Marwa Ebrahim, Julie Laroche   +4 more
doaj   +1 more source

How Will the Patient Protection and Affordable Care Act of 2010 Affect Children? [PDF]

, 2010
Summarizes how reform provisions including the mandate, expanded Medicaid coverage, and changes to parents' coverage will affect children in families of different income levels.
Genevieve M. Kenney, Jennifer E. Pelletier   +1 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Patients Under Pressure: Profiles of How Families Affected by Cancer Are Faring in the Recession [PDF]

, 2009
Describes how the loss of jobs and health insurance affected six cancer patients and their families. Examines barriers to maintaining health coverage, purchasing non-group coverage, and limitations on public ...
Karyn Schwartz, Kristi Martin, Stephen Finan   +2 more
core  

User-Centric Interference Nulling in Downlink Multi-Antenna Heterogeneous Networks

, 2016
In heterogeneous networks (HetNets), strong interference due to spectrum reuse affects each user's signal-to-interference ratio (SIR), and hence is one limiting factor of network performance. In this paper, we propose a user-centric interference nulling (
Clerckx, Bruno, Cui, Ying, Jiang, Dongdong, Wu, Yueping   +3 more
core   +1 more source