Results 101 to 110 of about 1,018,358 (274)
Edge Dominating Sets and Vertex Covers
Discussiones Mathematicae Graph Theory, 2013 Bipartite graphs with equal edge domination number and maximum matching cardinality are characterized. These two parameters are used to develop bounds on the vertex cover and total vertex cover numbers of graphs and a resulting chain of vertex covering ...
Dutton Ronald, Klostermeyer William F.
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Covering monolithic groups with proper subgroups [PDF]
International Journal of Group Theory, 2013 Given a finite non-cyclic group $G$, call $sigma(G)$ the smallest number of proper subgroups of $G$ needed to cover $G$. Lucchini and Detomi conjectured that if a nonabelian group $G$ is such that $sigma(G) < sigma(G/N)$ for every non-trivial normal ...
Martino Garonzi
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
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Projective covers and minimal free resolutions
International Journal of Mathematics and Mathematical Sciences, 1996 Using a generalization of the definition of the projective cover of a module, a special type of surjective free resolution, known as the projective cover of a complex, may be defined.
Mark A. Goddard
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
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, 1993 This paper introduces the theory of covers for functions defined over binary variables. Covers formalize the notion of decomposability. Large complex problems are decomposed into subproblems each containing fewer variables, which can then be solved in ...
Page, Scott E.
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