Results 81 to 90 of about 1,018,358 (274)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

On flat covers in varieties [PDF]

, 2008
summary:Flat covers do not exist in all varieties. We give a necessary condition for the existence of flat covers and some examples of varieties where not all algebras have flat ...
Ouyang, Baiyu, Li, Weiqing, Kruml, David
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Covering the Cover [PDF]

Gastroenterology, 2013
Anson W. Lowe, Richard H. Moseley
  +4 more sources

Dimension-Independent Kernel eps-Covers

Computing in Geometry and Topology
We introduce the notion of an eps-cover for a kernel range space. A kernel range space concerns a set of points X in Rd and the space of all queries by a fixed kernel (e.g., a Gaussian kernel K(p,.) = exp(-|p-.|2), where p is in \Rd).
Jeff Phillips, Hasan Pourmahmoodaghababa
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Economic Feasibility of Impermeable Lagoon Covers [PDF]

Environmental Economics and Policy,
Massey, Raymond E., Williams, Douglas W., Lazarus, William F., Miner, Ronald A., Lory, John, Shanklin, Dennis, Safley, Mac, Fleming, Ronald A.   +7 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

On regular covers at subsets

Applied General Topology
In this paper, we introduce and investigate the notions of cs-regular, sn-regular, so-regular, and regular families at arbitrary subsets of topological spaces.
Luong Quoc Tuyen, Nguyen Xuan Truc, Ong Van Tuyen   +2 more
doaj   +1 more source

VIETNAMESE TEXT EXTRACTION FROM BOOK COVERS

Tạp chí Khoa học Đại học Đà Lạt, 2017
Automatic information extraction from images reduces the cost, human interference, and timely processing. Converting printed book covers to readable text for later automation process would be useful for a wide range of users such as librarians, bookshop ...
Phan Thị Thanh Nga, Nguyễn Thị Huyền Trang, Nguyễn Văn Phúc, Thái Duy Quý, Võ Phương Bình   +4 more
doaj   +1 more source